Safflower yellow

Name: Safflower yellow
Brand: MedChemExpress
SKU: HY-N0938
Rating: 5.0 (3 reviews)

製品番号: HY-N0938: Data Sheet SDS COA 取扱説明書
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Safflower yellow is extracted from the flowers of the plant safflower (Carthamus tinctorius) and as the traditional Chinese medicine it has been extensively used for the treatment of cardio cerebrovascular diseases.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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Safflower yellow 構造式

CAS 番号 : 1401-20-3

容量	価格（税別）	在庫状況	数量
100 mg	$25	在庫あり	Estimated Time of Arrival: December 31
1 g	$45	在庫あり	Estimated Time of Arrival: December 31
5 g		お問い合わせ
10 g		お問い合わせ

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Based on 3 publication(s) in Google Scholar

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純度とドキュメンテーション
参考文献
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製品説明	Safflower yellow is extracted from the flowers of the plant safflower (Carthamus tinctorius) and as the traditional Chinese medicine it has been extensively used for the treatment of cardio cerebrovascular diseases.
体内実験	Safflower yellow (SY) is the safflower extract and is the one of traditional Chinese medicine. Safflower yellow can promote blood circulation, remove blood stasis, and thereby improve capillary circulation at the site of tissue injury. Safflower yellow is mixtures of a water-soluble chalcone component, in which both hydroxyl safflower yellow A (HSYA) and safflower yellow B (SYB) are the main components. Safflower injection excellently protects the heart by way of improving functions of cardiac contraction and dilation, increasing coronary blood flow, and strengthening the bcl-2 (anti apoptosis gene) protein expression. Safflower yellow alleviates the injured tendon adhesion and inflammatory reaction and promoted the repair of injured tendon^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Emission (Em)	500
Excitation (Ex)	320
CAS 番号	1401-20-3
Appearance	Solid
Color	Light brown to brown
SMILES	[Safflower yellow]
Structure Classification	Others
Initial Source	Plants Compositae Carthamus tinctorius L.
輸送条件	Room temperature in continental US; may vary elsewhere.
保管条件	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度	体外: DMSO : 20 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Molarity Calculator Dilution Calculator Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Mass = Concentration × Volume × Molecular Weight * Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final) 一般には略語で表示されます：C₁V₁ = C₂V₂ 濃度 _（開始） C1 × 体積 _（開始） V1 = 濃度 _（終了） C2 × 体積 _（終了） V2 In Vivo Dissolution Calculator Please enter the basic information of animal experiments: Dosage mg/kg Animal weight (per animal) g Dosing volume (per animal) μL Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments. Calculation results: Working solution concentration: mg/mL
純度とドキュメンテーション	Select Batch: データシート (271 KB) SDS (251 KB) COA (243 KB) 取扱説明書 (2659 KB)
参考文献	[1]. Zhou D, et al. The effect of safflower yellow on spinal cord ischemia reperfusion injury in rabbits. Oxid Med Cell Longev. 2013;2013:692302. [Content Brief]

動物実験
^[1]

Rabbits^[1]
The adult male New Zealand rabbits (body weight 2.0-2.5 kg) are used. Twenty-four rabbits are randomly divided into three groups (per group): sham-operated control (Cont), spinal cord ischemia reperfusion, and treated with safflower yellow. The control group only execute anesthesia and surgical procedures, except for occluding the abdominal aorta. The group is intravenously injected with 2 mL/kg of a solution of 16% (wt/vol) Safflower yellow (1 mL, containing 1.6 mg Safflower yellow), followed by continuous infusion of a total of 5 mL/kg through the right femoral vein at the moment of reperfusion beginning after 40 minutes of the abdominal aorta occlusion. The same volumes of 0.9% saline solution are administrated in control and groups. Blood samples are obtained at the end of 0 hour, 4 hours, 12 hours, 24 hours, and 48 hours after reperfusion, and the plasma is separated and stored at -80°C for further analysis. All animals are sacrificed 48 hours after reperfusion and are rapidly perfused with 0.9% sodium chloride, and the L2-5 segments of the spinal cord are quickly removed. The L2-3 segment in each animal is used for western blot, and the other segment (L4-5) is immersed into 10% neutral formaldehyde for 2-3 days and is used for morphology analysis^[1].

MedChemExpress (MCE) はこれらの方法の精度を確認していません。こちらは参照専用です。

参考文献

[1]. Zhou D, et al. The effect of safflower yellow on spinal cord ischemia reperfusion injury in rabbits. Oxid Med Cell Longev. 2013;2013:692302. [Content Brief]