1. Phenylpropanoids
  2. Schisanhenol

Schisanhenol (Synonyms: Schizanhenol; Gomisin-K3)

Cat. No.: HY-N0859 Purity: 99.70%
Handling Instructions

Schisanhenol is a natural compound solated from Schisandra rubriflora; UGT2B7 UDP-glucuronosyltransferases inhibitor.

For research use only. We do not sell to patients.

Schisanhenol Chemical Structure

Schisanhenol Chemical Structure

CAS No. : 69363-14-0

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 242 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 242 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 220 In-stock
Estimated Time of Arrival: December 31
25 mg USD 410 In-stock
Estimated Time of Arrival: December 31
50 mg USD 675 In-stock
Estimated Time of Arrival: December 31
100 mg USD 940 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Schisanhenol is a natural compound solated from Schisandra rubriflora; UGT2B7 UDP-glucuronosyltransferases inhibitor. IC50 value: Target: in vitro: Schisanhenol exhibited strong inhibition toward UGT2B7, with the residual activity to be 7.9% of control activity [1]. The BAECs were cultured with ox-LDL (200 microg/ml) in the presence and absence of Sal (10 and 50 micromol L(- 1)) for 24 h. The cytotoxicity of ox-LDL was evaluated by LDH leakage, cell viability and morphological change. Cell apoptosis was estimated by DNA ladder, chromatin condensation, and flow cytometry assay. The intracellular ROS production was detected by using DCF, a ROS probe, with laser confocal microscopy and flow cytometry. Sal was shown to reduce LDH leakage and increase cell viability. Sal also attenuated ox-LDL-induced BAECs apoptosis as indicated in typical internucleosomal DNA degradation (DNA ladder), condensed chromatin, and the sub-G1 peak appearance in flow cytometry assay [2]. in vivo: Sal significantly impeded production of MDA and loss of ATPase activity induced by reoxygenation following anoxia. Oral administration of Sal induced increase of cytosol glutathione-peroxidase of brain in mice under the condition of reoxygenation following anoxia [4].

Molecular Weight

402.48

Formula

C₂₃H₃₀O₆

CAS No.
SMILES

COC(C(OC)=C(OC)C=C1C[[email protected]](C)[[email protected]](C)C2)=C1C3=C2C=C(OC)C(OC)=C3O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (621.15 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4846 mL 12.4230 mL 24.8460 mL
5 mM 0.4969 mL 2.4846 mL 4.9692 mL
10 mM 0.2485 mL 1.2423 mL 2.4846 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (15.53 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6.25 mg/mL (15.53 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SchisanhenolSchizanhenol Gomisin-K3OthersInhibitorinhibitorinhibit

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Schisanhenol
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