2. Signalwege
  3. GPCR/G Protein
    Neuronal Signaling
  4. 5-HT Receptor

5-HT Receptor

Serotonin Receptor; 5-hydroxytryptamine Receptor

5-HT Receptor

Related Products

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5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems. Type: 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, 5-HT7. They mediate both excitatory and inhibitory neurotransmission. The serotonin receptors are activated by the neurotransmitter serotonin, which acts as their natural ligand. The serotonin receptors modulate the release of many neurotransmitters, as well as many hormones. The serotonin receptors influence various biological and neurological processes such as aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, andthermoregulation. The serotonin receptors are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics, anorectics,antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens.

5-HT Receptor Isoform Specific Products:

5-HT Receptor Isoform Comparison
Art. -Nr. Produktname Wirkung Reinheit Chemical Structure
  • HY-103152R
    GR 113808 (Standard)
    		Antagonist
    GR 113808 (Standard) is the analytical standard of GR 113808. This product is intended for research and analytical applications. GR 113808 is a potent and highly selective 5-HT4 receptor antagonist (pKb= 8.8). GR 113808 shows 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors.
    GR 113808 (Standard)
  • HY-103137R
    Zacopride hydrochloride (Standard)
    Zacopride (hydrochloride) (Standard) is the analytical standard of Zacopride (hydrochloride). This product is intended for research and analytical applications. Zacopride hydrochloride is a highly potent 5-HT3 receptor antagonist with Kis of 0.38 and 373 nM for 5-HT3 and 5-HT4 receptor, respectively. Zacopride hydrochloride is also a moderate IK1 channel agonist. Zacopride hydrochloride exerts significant antiarrhythmic and cardiac protective effects.
    Zacopride hydrochloride (Standard)
  • HY-123747A
    SC-53116 hydrochloride
    		Agonist
    SC-53116 hydrochloride is a selective 5-HT4 receptor agonist with EC50 at 23 nM.
    SC-53116 hydrochloride
  • HY-103156R
    NAS-181 dimesylate (Standard)
    		Antagonist
    NAS-181 dimesylate (Standard) is the analytical standard of NAS-181 dimesylate (HY-103156). This product is intended for research and analytical applications. NAS181 is a potent and selective antagonist of rat 5-HT1B receptor, with a Ki of 47 nM. NAS181 shows 13-fold selectivity for r5-HT1B over bovine 5-HT1B receptor (Ki=630 nM). NAS181 increases the 5-HT turnover and the synaptic concentration of 5-HT by inhibiting terminal r5-HT1B autoreceptors.
    NAS-181 dimesylate (Standard)
  • HY-111985
    Revospirone
    		Agonist
    Revospirone (BAY Vq 7813) is a partial agonist of the 5-HT1A receptor with a Ki of 2 nmol/L. Revospirone inhibits adenylate cyclase activity with an IC50 of 124 nmol/L.
    Revospirone
  • HY-13575S1
    Blonanserin-d5
    		Antagonist
    Blonanserin-d5 (AD-5423-d5) is a deuterium labeled Blonanserin (HY-13575). Blonanserin is a dopamine D2/5-HT2 receptor antagonist and an atypical antipsychotic.
    Blonanserin-d<sub>5</sub>
  • HY-169785
    7-Methyl DMT
    		Agonist
    7-Methyl DMT (7-TMT) is a 5-HT2 receptor agonist. Structurally, 7-Methyl DMT is a tryptamine derivative. It can be used as an analytical reference standard for the psychoactive substance DOM. 7-Methyl DMT is also used in research in the field of neurological diseases.
    7-Methyl DMT
  • HY-100166R
    AP521 (Standard)
    		Agonist
    AP521 (Standard) is the analytical standard of AP521 (HY-100166). This product is intended for research and analytical applications. AP521 is an agonist of human 5-HT1A receptor with an IC50 of 94 nM.
    AP521 (Standard)
  • HY-102057R
    Felcisetrag (Standard)
    		Agonist
    Felcisetrag (Standard) is the analytical standard of Felcisetrag (HY-102057). This product is intended for research and analytical applications. Felcisetrag (TD-8954) is an orally active, potent and selective 5-HT4 receptor agonist with gastrointestinal prokinetic properties. Felcisetrag has high affinity (pKi =9.4) for human 5-HT4(c) receptors.
    Felcisetrag (Standard)
  • HY-101924R
    AVN-492 (Standard)
    		Antagonist
    AVN-492 (Standard) is the analytical standard of AVN-492 (HY-101924). This product is intended for research and analytical applications. AVN-492 is a very specific and highly-selective antagonist with picomolar affinity to 5-HT6R (Ki=91 pM).
    AVN-492 (Standard)
  • HY-116065
    CUMI-101
    		Agonist
    CUMI-101 (compound 8) is a 5-HT1AR agonist (Ki=0.15 nM) with an EC50 of 0.1 nM in the [35S]GTPγS binding assay. CUMI-101 can be used in the research of neurological diseases.
    CUMI-101
  • HY-133790
    Palonosetron N-oxide
    		Control
    Palonosetron N-oxide is a metabolite of the serotonin (5-HT) receptor subtype 5-HT3 antagonist Palonosetron (HY-A0018).
    Palonosetron N-oxide
  • HY-B0478AR
    Trazodone (Standard)
    		Antagonist
    Trazodone (AF-1161 free base) (Standard) is the analytical standard of Trazodone. This product is intended for research and analytical applications. Trazodone is a triazolopyridine derivative that belongs to the class of serotonin receptor antagonists and reuptake inhibitors (SARIs). Trazodone has anti-depressant and anti-insomnious activity. Trazodone exerts antagonistic properties against a1- and a2-adrenergic receptors and histamine H1 receptors, with minimal anticholinergic effects.
    Trazodone (Standard)
  • HY-10791R
    Ritanserin (Standard)
    		Antagonist
    Ritanserin (Standard) is the analytical standard of Ritanserin. This product is intended for research and analytical applications. Ritanserin (R 55667) is a highly potent, relatively selective, orally active, long acting antagonist of 5-HT2 receptor, with an IC50 of 0.9 nM, less active on Histamine H1, Dopamine D2, Adrenergic α1, Adrenergic α2 receptors.
    Ritanserin (Standard)
  • HY-44132A
    Dehydro Palonosetron hydrochloride
    		Antagonist
    Dehydro Palonosetron hydrochloride (RS 42358-197 hydrochloride) is a 5-HT3 receptor antagonist. Dehydro Palonosetron hydrochloride has an antiemetic effect.
    Dehydro Palonosetron hydrochloride
  • HY-106644
    Femoxetine
    		Inhibitor
    Femoxetine is a serotonin (5-HT) inhibitor with antidepressant properties. Femoxetine increases serotonin levels in the brain by preventing serotonin from being reabsorbed by nerve cells, resulting in increased concentrations of the neurotransmitter in the synaptic gap, which enhances serotonin signaling. Femoxetine can be used to study the role of serotonin in depression and other emotional disorders, and how 5-HT reuptake inhibitors affect mood and behavior.
    Femoxetine
  • HY-128715
    Fluperlapine
    		Antagonist
    Fluperlapine (NB 106-689) is a potent antagonist of 5-HT receptor. Fluperlapine can be used in antidepressant research.
    Fluperlapine
  • HY-103142R
    AS19 (Standard)
    		Agonist
    AS19 (Standard) is the analytical standard of AS19 (HY-103142). This product is intended for research and analytical applications. AS19 is a potent, selective 5-HT7 receptor agonist with an IC50 value of 0.83 nM and a Ki of 0.6 nM. AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Kis = 89.7 nM, 490 nM, 6.6 nM and 98.5 nM, respectively). AS19 enhances memory consolidation and reverses Scopolamine- or Dizocilpine-induced amnesia.
    AS19 (Standard)
  • HY-401563
    5-HT2A antagonist 4 methanesulfonate
    		Antagonist
    5-HT2A antagonist 4 methanesulfonate (Example 29) is a dopamine D2 receptor and serotonin 5HT2A receptor antagonist. 5-HT2A antagonist 4 methanesulfonate can be used for the study of central nervous system diseases.
    5-HT2A antagonist 4 methanesulfonate
  • HY-W740014
    N-Desmethyl Zolmitriptan
    		Agonist
    N-Desmethyl Zolmitriptan (183C91; DZT) is the active metabolite of the serotonin (5-HT) receptor subtype 5-HT1B and 5-HT1D agonist Zolmitriptan (HY-B0229). N-Desmethyl Zolmitriptan (183C91; DZT) is an agonist of 5-HT1B receptors and induces constriction in isolated human cerebral arteries (EC50=100 nM).
    N-Desmethyl Zolmitriptan
Art. -Nr. Produktname / Synonyms Application Reactivity
5-HT Receptor Isoform Comparison

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