2. Others GPCR/G Protein Neuronal Signaling
  3. Reference Standards 5-HT Receptor
  4. NAS-181 dimesylate (Standard)

NAS-181 dimesylate (Standard) is the analytical standard of NAS-181 dimesylate (HY-103156). This product is intended for research and analytical applications. NAS181 is a potent and selective antagonist of rat 5-HT1B receptor, with a Ki of 47 nM. NAS181 shows 13-fold selectivity for r5-HT1B over bovine 5-HT1B receptor (Ki=630 nM). NAS181 increases the 5-HT turnover and the synaptic concentration of 5-HT by inhibiting terminal r5-HT1B autoreceptors.

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NAS-181 dimesylate (Standard)

NAS-181 dimesylate (Standard) Chemical Structure

CAS No. : 1217474-40-2

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Information

NAS-181 dimesylate (Standard) is the analytical standard of NAS-181 dimesylate (HY-103156). This product is intended for research and analytical applications. NAS181 is a potent and selective antagonist of rat 5-HT1B receptor, with a Ki of 47 nM. NAS181 shows 13-fold selectivity for r5-HT1B over bovine 5-HT1B receptor (Ki=630 nM). NAS181 increases the 5-HT turnover and the synaptic concentration of 5-HT by inhibiting terminal r5-HT1B autoreceptors.

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Molecular Weight

538.63

Formula

C21H34N2O10S2
CAS No.
SMILES

CS(=O)(O)=O.CS(=O)(O)=O.[C@H]1(COC2=CC=CC3=C2OCC(CN4CCOCC4)=C3)CNCCO1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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NAS-181 dimesylate (Standard) Related Classifications

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Keywords:

NAS-181 dimesylate (Standard)1217474-40-2Reference Standards5-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptorrat5-HT1B5-HTInhibitorinhibitorinhibit

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