2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. Estrogen Receptor/ERR
  5. ERRγ Isoform

ERRγ

ERRγ (ESRRG/NR3B3) is a constitutively active nuclear receptor that functions as a transcriptional regulator without an identified physiological ligand[1]. Mechanistically, ERRγ coordinates oxidative metabolism: in skeletal muscle, ERRγ expression drives fat metabolism, mitochondrial respiration, type I fiber specification, angiogenesis, mitochondrial biogenesis, antioxidant defense, and oxidative remodeling[2][3]. In cardiac muscle, ERRα and ERRγ jointly regulate cardiomyocyte metabolism and function, showing functional overlap in high-energy tissues[4]. In liver models, ERRγ coordinates endocrine and metabolic signals that alter glucose, lipid, alcohol, and iron metabolism, linking ERRγ dysregulation to hyperglycemia, insulin resistance, and alcoholic liver injury[5]. In cancer models, ERRγ induces E-cadherin, promotes mesenchymal-to-epithelial transition, and suppresses breast tumor growth, while gastric cancer studies identify ESRRG as a negative regulator of Wnt signaling and a tumor suppressor[6][7]. Compared with related isoforms, ERRα and ERRγ share metabolic transcriptional roles, whereas ERRβ is less defined metabolically and is linked more strongly to embryonic stem cell pluripotency[8]. For experimental applications, GSK5182 suppresses ERRγ-driven hepatic gluconeogenesis, while DY131 activates ESRRG-dependent suppression of gastric cancer growth and Wnt signaling[9][7].

ERRγ Related Products (9):

Cat. No. Product Name Effect Purity
  • HY-155673
    SLU-PP-332
    		Agonist 98.98%
    SLU-PP-332 is a pan-Estrogen Receptor/ERR agonist with EC50 values of 98, 230 and 430 nM for ERRα, ERRβ and ERRγ, respectively. SLUPP-332 enhances mitochondrial function and cellular respiration in skeletal muscle cell lines. SLU-PP-332 has the potential to study metabolic diseases as well as improve muscle function.
  • HY-15483
    DY131
    		Agonist 99.72%
    DY131 (GSK 9089) is a potent and selective ERRγ and ERRβ agonist. DY131displays inactive against ERRα, ERα and ERβ. DY131 also inhibits Smo signaling.
  • HY-111226
    GSK5182
    		Inhibitor 99.10%
    GSK5182 is a highly selective and orally active inverse agonist of estrogen-related receptor γ (ERRγ) with an IC50 of 79 nM. GSK5182 does not interact with other nuclear receptors, including ERRα or ERα. GSK5182 also induces reactive oxyen species (ROS) generation in hepatocellular carcinoma (HCC).
  • HY-145848
    ERRγ agonist-1
    		Agonist 98.02%
    ERRγ agonist-1 is a potent ERRγ agonist. ERRγ agonist-1 increases transcriptional activities of ERRγ. ERRγ agonist-1 has the potential for the research of neuropsychological disorders.
  • HY-137818
    SR19881
    		Agonist 99.30%
    SR19881 is a potent dual agonist of ERRγ and ERRβ, with EC50 values of 0.39 and 0.63 μM, respectively.
  • HY-177011
    ERRγ-IN-1
    		Inhibitor
    ERRγ-IN-1 is a ERRγ inhibitor with an IC50 of 0.040 μM. ERRγ-IN-1 activates MAPK (p44/p42) and inhibits the activity of ERRγ. ERRγ-IN-1 significantly increases iodine uptake in anaplastic thyroid carcinoma xenografts and suppresses tumor growth in nude mice. ERRγ-IN-1 is applicable for the research of anaplastic thyroid carcinoma.
  • HY-W009066
    2-Ethylhexyl diphenyl phosphate
    		Inhibitor
    2-Ethylhexyl diphenyl phosphate is an organophosphate flame retardants (OPFRs) and a PPARG agonist (EC20: 2.04 µM). 2-Ethylhexyl diphenyl phosphate also inhibits ERRγ transcriptional activity (IC50: 1.3 µM). 2-Ethylhexyl diphenyl phosphate upregulates 3β-HSD1, human chorionic gonadotropin (hCG) and progesterone secretion. 2-Ethylhexyl diphenyl phosphate can be used in studies of female reproduction and fetal development.
  • HY-149833
    ERRγ inverse agonist 2
    		Agonist
    ERRγ inverse agonist 2 (compound 19) is a potent and selective ERRγ inverse agonist with a Kd value of 6.5 μM. ERRγ inverse agonist 2 inhibits the expression of hepcidin, fibrinogen and gluconeogenic genes. ERRγ inverse agonist 2 has antimicrobial, anti-coagulant and antidiabetic activities.
  • HY-114411
    ERRγ inverse agonist 1
    		Antagonist
    ERRγ inverse agonist 1 (Compound 12) is a selective ERRγ inverse agonist with an IC50 value of 0.040 μM against ERRγ. ERRγ inverse agonist 1 inhibits the activity of ERRγ at the functional level. ERRγ inverse agonist 1 can be used in the research of anaplastic thyroid cancer.