ERRγ inverse agonist 1
ERRγ inverse agonist 1 (Compound 12) is a selective ERRγ inverse agonist with an IC50 value of 0.040 μM against ERRγ. ERRγ inverse agonist 1 inhibits the activity of ERRγ at the functional level. ERRγ inverse agonist 1 can be used in the research of anaplastic thyroid cancer.
For research use only. We do not sell to patients.
- CAS No.: 2316832-86-5
- Formula: C30H38Cl2N2O2
- Molecular Weight:529.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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ERRγ 0.040 μM (IC50) |
ERRβ 1.330 μM (IC50) |
ERα 1.240 μM (IC50) |
ERRγ inverse agonist 1 potently inhibits the binding of ERRγ in a cell-free TR-FRET assay, with an IC50 of 0.040 μM[1].
ERRγ inverse agonist 1 (10 μM; 15 min) inhibits the activities of CYP 2D6 and CYP 3A4 by 36.5% and 33.6%, respectively, in in vitro microsomal assays, while exerting extremely weak inhibitory effects on other tested CYP subtypes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2316832-86-5
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Molecular Weight 529.54
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Formula C30H38Cl2N2O2
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SMILES
OC1=CC=CC(/C(C2=CC=C(N3CCN(C(C)C)CC3)C=C2)=C(C4=CC=CC=C4)\CCCO)=C1.[H]Cl.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ERRγ inverse agonist 1 Related Classifications
HY-114411 Related Classifications
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