2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-163463
    PTP1B-IN-25
    		Inhibitor
    PTP1B-IN-25 (Compound 19) is a PTP1B inhibitor with remarkable antiviral, antibacterial, and antidiabetic activities. PTP1B-IN-25 has IC50 values of 0.37 μM, 8.6 μM, 3.7 μM, and 29 μM against PTP1B, HIV, α-Glucosidase, and methicillin-resistant Staphylococcus aureus (MRSA) respectively.
    PTP1B-IN-25
  • HY-156149
    CYP51/PD-L1-IN-1
    		Inhibitor
    CYP51/PD-L1-IN-1 (compound L11) is a quinazoline compound with antifungal activity. CYP51/PD-L1-IN-1 is a dual inhibitor of CYP51 (IC50: 0.884 μM) and PD-L1 (IC50: 0.083 μM), which can induce early apoptosis of fungal cells in the cell cycle. CYP51/PD-L1-IN-1 also significantly reduced intracellular IL-2, NLRP3, and NF-κBp65 protein levels, induced mitochondrial damage and ROS accumulation, and ultimately led to fungal lysis and death.
    CYP51/PD-L1-IN-1
  • HY-155710
    Antifungal agent 68
    		Inhibitor
    Antifungal agent 68 (compound 10) is an antifungal agent against Candida and Cryptococcus gattii. Antifungal agent 68 inhibits fungal ergosterol biosynthesis, possibly by targeting lanosterol 14α-demethylase (CYP51). There is an interaction between the imidazole ring of antifungal agent 68 and the heme group of CYP51.
    Antifungal agent 68
  • HY-158402
    Anti-inflammatory agent 84
    		Inhibitor
    Anti-inflammatory agent 84 (Compound 4D) is a derivative of Coumarin (HY-N0709) with antimicrobial and anti-inflammatory activities. Anti-inflammatory agent 84 inhibits E. coli, Candida albicans, Staphylococcus aureus and methicillin-resistant S. aureus (MRSA), with MIC of 312, 156, 19 and 316 μg/mL, respectively. Anti-inflammatory agent 84 inhibits biofilm formation of S. aureus, E. coli and MRSA, with IC50 of 185, 321 and 99 μM, respectively. Anti-inflammatory agent 84 inhibits nitric oxide production in Lipopolysaccharide (HY-D1056)-stimulated RAW264.7 macrophage cell.
    Anti-inflammatory agent 84
  • HY-N0080
    Ulopterol
    		Inhibitor
    Ulopterol is a coumarin isolated from the leaves of Toddalia asiatica (L.) Lam with potent antibacterial and antifungal activities.
    Ulopterol
  • HY-N16430
    Neovasinin
    Neovasinin is a phytotoxin that can be produced by the fungus Neocosmospora vasinfecta. Neovasinin exhibits toxic effects on soybean plants.
    Neovasinin
  • HY-W716464
    Prochloraz-d7
    Prochloraz-d7 (BTS 40542-d7) is the deuterium labeled Prochloraz (HY-B0845). Prochloraz is an imidazole antifungal. Prochloraz is as an estrogen receptor (ER) and androgen receptor (AR) antagonist and an aromatase inhibitor with IC50 values of 25 μM, 4 μM and 0.3 μM, respectively. Prochloraz is able to activate the aryl hydrocarbon receptor (AhR) having an EC50 of 1 μM.
    Prochloraz-d<sub>7</sub>
  • HY-109125A
    Amcipatricin L-aspartate
    		Inhibitor
    Amcipatricin diaspartate (SPA-S-753) is a semi-synthetic polyene antibiotic, with potent broad-spectrum antifungal activity.
    Amcipatricin L-aspartate
  • HY-121780
    Aranorosin
    		Inhibitor
    Aranorosin, a potent antifungal antibiotic, has been isolated from the culture filtrate and mycelium of a strain of Pseudoarachniotus roseus Kuehn.
    Aranorosin
  • HY-155660
    Antifungal agent 63
    		Inhibitor
    Antifungal agent 63 (Compound 3i) is a fungicidal agent with excellent fungicidal activities against Fusarium oxysporum f.sp. cucumerinum. Antifungal agent 63 can be used for antiviral and fungicidal research.
    Antifungal agent 63
  • HY-P5703
    EP5-1
    		Inhibitor
    EP5-1 is an antimicrobial peptide. EP5-1 has antibacterial and antifungal activities. EP5-1 also shows antitumor activity against cancer cells, and induces cell apoptosis. EP5-1 has antiviral activity against pseudorabies virus (PRV).
    EP5-1
  • HY-107126B
    Ibrexafungerp phosphate
    		Inhibitor
    Ibrexafungerp phosphate is an orally active β-1,3-glucan synthesis inhibitor, with potential antifungal activity. Ibrexafungerp phosphate can be used for research of Candida and Aspergillus infections.
    Ibrexafungerp phosphate
  • HY-145437
    N'-(2-Fluorophenyl)pyrazine-2-carbohydrazide
    		Inhibitor
    N'-(2-Fluorophenyl)pyrazine-2-carbohydrazide is a Ole1p desaturase inhibitor and antifungal agent.
    N'-(2-Fluorophenyl)pyrazine-2-carbohydrazide
  • HY-167843
    Alborixin
    		Inhibitor
    Alborixin is a polycyclic polyether ionophore Antibiotic. Alborixin is isolated from cultures of Streptomyces albus. Alborixin induces Autophagy via PTEN-mediated inhibition of the AKT pathway, thereby clearing Amyloid-β. Alborixin exhibits activity against Gram-positive bacteria and fungi. Alborixin can be used in the research of Alzheimer's disease.
    Alborixin
  • HY-P1934AR
    Cyclo(L-Phe-L-Pro) (Standard)
    		Inhibitor
    Gallic acid (hydrate) (Standard) is the analytical standard of Gallic acid (hydrate). This product is intended for research and analytical applications. Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide. Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation. Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC50 of 24 µM in the DPPH assay.
    Cyclo(L-Phe-L-Pro) (Standard)
  • HY-149615
    Antibacterial agent 157
    		Inhibitor
    Antibacterial agent 157 (compound B12) is a fungicidal agent. Antibacterial agent 157 can influence the protein synthesis of Botrytis cinerea. Antibacterial agent 157 can be used for gray mold resistance control research.
    Antibacterial agent 157
  • HY-P5569
    SP-B peptide
    		Inhibitor
    SP-B peptide is an antimicrobial peptide. SP-B peptide has antifungal activity against strains of Cryptococcus neoformans, Candida albicans and Aspergillus fumigatus
    SP-B peptide
  • HY-P11125
    Metchnikowin
    		Inhibitor
    Metchnikowin is a fruit fly antimicrobial peptide rich in proline, with dual antibacterial and antifungal activities. Metchnikowin can be independently regulated by TOLL and IMD pathways. Metchnikowin is often used in the research of infectious conditions.
    Metchnikowin
  • HY-N19755
    Clemontanoside-C
    		Inhibitor
    Clemontanoside-C is an oleanane-based triterpenoid saponin and antifungal agent found in the roots of Lepidagathis cuspidata. Clemontanoside-C acts against Aspergillus flavus, Rhizopus stolinifer, Penicillum nodatum, and Aspergillus fumigatus. Clemontanoside-C can be used for the research of fungal infections.
    Clemontanoside-C
  • HY-151556
    Antifungal agent 45
    		Inhibitor
    Antifungal agent 45 is with fungicidal activities. Antifungal agent 45 shows excellent characteristics superior to Kresoxim-methyl (HY-125776), in which the activity enhancement against Phytophthora capsici was the most remarkable, with an EC50 value of about 5 μM.
    Antifungal agent 45
Cat. No. Product Name / Synonyms Application Reactivity