2. Signaling Pathways
  3. Anti-infection
  4. Fungal
  5. Fungal Control

Fungal Control

Fungal Controls (5):

Cat. No. Product Name Effect Purity
  • HY-N19838
    Kipukasin C
    		Control
    Kipukasin C is an aroyl Uridine (HY-B1449) derivative found in Aspergillus versicolor. Kipukasin C shows no antifungal activity.
  • HY-126929
    Trioxacarcin B
    		Control
    Trioxacarcin B (TXN-B) is a potent cytotoxic agent and DNA-targeted inhibitor. Trioxacarcin B disrupts DNA function and induces apoptosis in cancer cells. Trioxacarcin B not only effectively inhibits the growth of various Gram-positive and Gram-negative bacteria as well as Plasmodium falciparum, but also blocks the colony formation of cancer stem cells, significantly reduces tumor volume and prolongs survival in preclinical in vivo models. The activity of Trioxacarcin B is highly dependent on its intact spiro-epoxide structure; it loses efficacy once this moiety undergoes hydrolysis, and Trioxacarcin B shows no activity against fungi, microalgae and small RNA viruses. Trioxacarcin B can be used for research on bacterial infections, malaria, and various cancers including colon cancer and melanoma.
  • HY-107211
    Echinocandin B nucleus
    		Control
    Echinocandin B nucleus (A-30912 A nucleus) is the reaction product catalyzed by Echinocandin B (HY-125723) deacylase. Echinocandin B nucleus serves as an intermediate for the synthesis of semi-synthetic antifungal agents.
  • HY-118484
    (RS)-Sakuranetin
    		Control
    (RS)-Sakuranetin is the racemate of Sakuranetin (HY-N3006).
  • HY-129432
    (-)-Deacetylsclerotiorin
    		Control
    (-)-Deacetylsclerotiorin (Compound 30) is the enantiomer of Deacetylsclerotiorin (HY-126167). Deacetylsclerotiorin is the metabolite of chloramphenicol isolated from the fungus Bartalinia robillardoides strain LF550. Deacetylsclerotiorin has significant inhibitory effects on Candida albicans (IC50=24 μM), Trichophyton rubrum (IC50=2.83 μM) and Septoria tritici (IC50=7.45 μM). In addition, Deacetylsclerotiorin also exhibits inhibitory effects on the enzyme phosphodiesterase 4 (PDE4) (IC50=2.8 μM).