61248-35-9
Chemical Structure
(-)-Deacetylsclerotiorin
- CAS No.: 61248-35-9
- Formula:C19H21ClO4
- Molecular Weight:348.82
IUPAC Name: (S)-5-chloro-3-((S,1E,3E)-3,5-dimethylhepta-1,3-dien-1-yl)-7-hydroxy-7-methyl-6H-isochromene-6,8(7H)-dione
InChIKey: SBUBEONHXLXYBK-ZFMXKZNFSA-N
SMILES: ClC1=C2C(C([C@](O)(C1=O)C)=O)=COC(/C=C/C(C)=C/[C@@H](C)CC)=C2
Biological Activity: (-)-Deacetylsclerotiorin (Compound 30) is the enantiomer of Deacetylsclerotiorin (HY-126167). Deacetylsclerotiorin is the metabolite of chloramphenicol isolated from the fungus Bartalinia robillardoides strain LF550. Deacetylsclerotiorin has significant inhibitory effects on Candida albicans (IC50=24 μM), Trichophyton rubrum (IC50=2.83 μM) and Septoria tritici (IC50=7.45 μM). In addition, Deacetylsclerotiorin also exhibits inhibitory effects on the enzyme phosphodiesterase 4 (PDE4) (IC50=2.8 μM)[1].
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(-)-Deacetylsclerotiorin | (-)-Deacetylsclerotiorin (Compound 30) is the enantiomer of Deacetylsclerotiorin (HY-126167). Deacetylsclerotiorin is the metabolite of chloramphenicol isolated from the fungus Bartalinia robillardoides strain LF550. Deacetylsclerotiorin has significant inhibitory effects on Candida albicans (IC50=24 μM), Trichophyton rubrum (IC50=2.83 μM) and Septoria tritici (IC50=7.45 μM). In addition, Deacetylsclerotiorin also exhibits inhibitory effects on the enzyme phosphodiesterase 4 (PDE4) (IC50=2.8 μM). | |||||||||||||||||||||
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Keywords
