Antifungal agent 68
Antifungal agent 68 (compound 10) is an antifungal agent against Candida and Cryptococcus gattii. Antifungal agent 68 inhibits fungal ergosterol biosynthesis, possibly by targeting lanosterol 14α-demethylase (CYP51). There is an interaction between the imidazole ring of antifungal agent 68 and the heme group of CYP51.
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- CAS No.: 2925307-53-3
- Formule: C23H27ClN2O3
- Masse moléculaire:414.93
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| H9c2 | CC50 |
44.2 μM
Compound: 10
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Cytotoxicity against H9c2 cells assessed as inhibition of cell proliferation incubated for 72 hrs by resazurin dye based microplate reader analysis
Cytotoxicity against H9c2 cells assessed as inhibition of cell proliferation incubated for 72 hrs by resazurin dye based microplate reader analysis
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[PMID: 37146343] |
Chemical Information
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CAS No. 2925307-53-3
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Masse moléculaire 414.93
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Formule C23H27ClN2O3
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SMILES
CCCC1=CC=C(OCC(OCC2=CC=C(Cl)C=C2)CN3C=CN=C3)C(OC)=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antifungal agent 68 Related Classifications
HY-155710 Related Classifications
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