2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog 관련 제품 (2417):

Cat. No. 상품명 효과 Purity Chemical Structure
  • HY-158200
    5-Aminoallyl-dUTP
    5-Aminoallyl-dUTP (5-Aminoallyl 2'-deoxyuridine 5'-triphosphate) is a monomeric raw material that can be used for nucleic acid synthesis.
    5-Aminoallyl-dUTP
  • HY-101904
    2-Chloro-2'-deoxycytidine
    2-Chloro-2'-deoxycytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities.
    2-Chloro-2'-deoxycytidine
  • HY-137649A
    Sp-2'-O-Me-CTPαS tetrasodium
    Sp-2'-O-Me-CTPαS tetrasodium is an analog of CTP. Sp-2'-O-Me-CTPαS tetrasodium can be used enzymatically to introduce thiophosphate and modified 2'-OH groups into RNA.
    Sp-2'-O-Me-CTPαS tetrasodium
  • HY-178538
    DMTr-2'-O-Me-rG(iBu)-3'-(D)-DPSE-phosphoramidite
    DMTr-2'-O-Me-rG(iBu)-3'-(D)-DPSE-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-O-Me-rG(iBu)-3'-(D)-DPSE-phosphoramidite
  • HY-178523
    6'-O-DMTr-2'-O-Me-5'-Homo-C(Ac)-3'-CE-phosphoramidite
    6'-O-DMTr-2'-O-Me-5'-Homo-C(Ac)-3'-CE-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    6'-O-DMTr-2'-O-Me-5'-Homo-C(Ac)-3'-CE-phosphoramidite
  • HY-178524
    6'-O-DMTr-2'-O-Me-5'-Homo-G(iBu)-3'-CE-phosphoramidite
    6'-O-DMTr-2'-O-Me-5'-Homo-G(iBu)-3'-CE-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    6'-O-DMTr-2'-O-Me-5'-Homo-G(iBu)-3'-CE-phosphoramidite
  • HY-145978
    3'-OMe-m7GpppGmpG
    3'-OMe-m7GpppGmpG is a monomeric raw material that can be used for nucleic acid synthesis.
    3'-OMe-m7GpppGmpG
  • HY-180479
    Nucleoside-analog-3
    Nucleoside-analog-3 (compound 59) is a S-cEt guanosine intermediate.
    Nucleoside-analog-3
  • HY-200306
    DMTr-2'-O-C16-rU-3'-CE-phosphoramidite
    		98.16%
    DMTr-2'-O-C16-rU-3'-CE-Phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-O-C16-rU-3'-CE-phosphoramidite
  • HY-178608
    (2'OMe-5'p(S)-A)pG
    (2'OMe-5'p(S)-A)pG is a monomeric raw material that can be used for nucleic acid synthesis.
    (2'OMe-5'p(S)-A)pG
  • HY-178531
    3'-ONH2-dATP
    3'-ONH2-dATP is a 3'-O-blocked reversible terminator deoxynucleotide triphosphate. 3'-ONH2-dATP stops DNA polymerization after single-nucleotide addition to an initiator strand, and its 3'-ONH2 blocking group can be removed to restore a free 3'-OH for subsequent extension.
    3'-ONH2-dATP
  • HY-W894386
    3′-O-Azidomethyl-dUTP
    3′-O-Azidomethyl-dUTP is a monomeric raw material that can be used for nucleic acid synthesis.
    3′-O-Azidomethyl-dUTP
  • HY-178586
    5-CF₃-ddUTP
    5-CF?-ddUTP is a monomeric raw material that can be used for nucleic acid synthesis.
    5-CF₃-ddUTP
  • HY-112582AGL
    N1-Methylpseudouridine-5′-triphosphate (GMP like)
    N1-Methylpseudouridine-5′-triphosphate (GMP like) (1-Methylpseudouridine-5′-triphosphate (GMP like)) is N1-Methylpseudouridine-5′-triphosphate (HY-112582A) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. N1-Methylpseudouridine-5′-triphosphate (1-Methylpseudouridine-5′-triphosphate) is a nucleobase-modified nucleotide, used for synthesizing mRNA with reduced immunogenicity and improved stability.
    N1-Methylpseudouridine-5′-triphosphate (GMP like)
  • HY-172003
    Isoorotidine
    Isoorotidine is a nucleoside derivative and an isomer of the pyrimidine nucleoside Orotidine (HY-113226).
    Isoorotidine
  • HY-128472
    Biotin-11-dATP
    Biotin-11-dATP is a monomeric raw material that can be used for nucleic acid synthesis.
    Biotin-11-dATP
  • HY-A0063R
    Tipiracil hydrochloride (Standard)
    		Inhibitor
    Tipiracil (hydrochloride) (Standard) is the analytical standard of Tipiracil (hydrochloride). This product is intended for research and analytical applications. Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.
    Tipiracil hydrochloride (Standard)
  • HY-137619B
    Rp-dCTPαS
    Rp-dCTPαS is a monomeric raw material that can be used for nucleic acid synthesis.
    Rp-dCTPαS
  • HY-178682
    DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-(L)-PSM-phosphoramidite
    DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-(L)-PSM-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-(L)-PSM-phosphoramidite
  • HY-178560
    3'-β-F-2'-5-Me-dU
    3'-β-F-2'-5-Me-dU is a monomeric raw material that can be used for nucleic acid synthesis.
    3'-β-F-2'-5-Me-dU