2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. 상품명 CAS No. Purity 화학구조
  • HY-122702
    PEG6-(CH2CO2H)2 77855-76-6
    PEG6-(CH2CO2H)2 is a symmetric PEG PROTAC linker, for the synthesis of Homo-PROTACs which is bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.
    PEG6-(CH2CO2H)2
  • HY-W002680
    (2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 114676-69-6 99.96%
    N-Boc-cis-4-hydroxy-D-proline methyl ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-D-proline methyl ester is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1
    (2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate
  • HY-W096107
    Benzyl-PEG8-alcohol 477775-73-8 99.82%
    Benzyl-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG8-alcohol
  • HY-42618
    Azido-PEG4-CH2-Boc 864681-04-9
    Azido-PEG4-CH2-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG4-CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-CH2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-CH2-Boc
  • HY-130475
    Azido-PEG9-acid 1670249-37-2
    Azido-PEG9-acid is a non-cleavable 9 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG9-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Azido-PEG9-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG9-acid
  • HY-140821
    Bromo-PEG4-azide 1951439-37-4 98.14%
    Bromo-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromo-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Bromo-PEG4-azide
  • HY-45018
    Tos-PEG3-CH2COOtBu 1530778-24-5 98.63%
    Tos-PEG3-CH2COOtBu is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tos-PEG3-CH2COOtBu
  • HY-130662
    Hydroxy-PEG8-Boc 1334177-84-2 99.8%
    Hydroxy-PEG8-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Hydroxy-PEG8-Boc
  • HY-141359
    (2-Pyridyldithio)-PEG4-alcohol 851961-99-4 98.85%
    (2-Pyridyldithio)-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    (2-Pyridyldithio)-PEG4-alcohol
  • HY-140410
    Bis-aminooxy-PEG4 98627-72-6
    Bis-aminooxy-PEG4 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis-aminooxy-PEG4
  • HY-140896
    Biotin-PEG5-amine 113072-75-6
    Biotin-PEG5-amine is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG5-amine
  • HY-140929
    Bis-Biotin-PEG23 293298-36-9
    Bis-Biotin-PEG23 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis-Biotin-PEG23
  • HY-140076
    endo-BCN-PEG2-alcohol 1807501-85-4 98.0%
    endo-BCN-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. endo-BCN-PEG2-alcohol is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    endo-BCN-PEG2-alcohol
  • HY-140825
    Bromoacetamido-PEG3-azide 940005-81-2
    Bromoacetamido-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromoacetamido-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Bromoacetamido-PEG3-azide
  • HY-141180
    TCO-PEG6-amine 2353409-94-4 98.96%
    TCO-PEG6-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    TCO-PEG6-amine
  • HY-W043840
    m-PEG5-CH2CH2COOH 1347750-72-4
    m-PEG5-CH2CH2COOH is a PEG-based based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG5-CH2CH2COOH
  • HY-141380
    Bromoacetamido-PEG2-C2-acid 1415800-44-0 99.82%
    Bromoacetamido-PEG2-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromoacetamido-PEG2-C2-acid
  • HY-141387
    Bromoacetamido-PEG4-NHS ester 1260139-70-5 98.69%
    Bromoacetamido-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromoacetamido-PEG4-NHS ester
  • HY-124386
    DBCO-NHCO-PEG4-amine 1255942-08-5
    DBCO-NHCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE (HY-15162) and antibody (e.g., DBCO-VCpAB MMAE and DBCO-TRX MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively).
    DBCO-NHCO-PEG4-amine
  • HY-140106
    Azido-PEG3-SS-PEG3-azide 1310827-27-0 99.29%
    Azido-PEG3-SS-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-SS-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-SS-PEG3-azide
PROTAC Linkers Isoform Comparison

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