Azido-PEG9-acid
Based on 1 Customer Validation
Azido-PEG9-acid is a non-cleavable 9 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG9-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Azido-PEG9-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
For research use only. We do not sell to patients.
- Purity: 97.74%
- CAS No.: 1670249-37-2
- Formula: C21H41N3O11
- Molecular Weight:511.56
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
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PEGs |
Non-cleavable Linker |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1670249-37-2
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Appearance Liquid
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Molecular Weight 511.56
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Formula C21H41N3O11
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Color Colorless to light yellow
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SMILES
O=C(O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 100 mg/mL (195.48 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (265 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9548 mL | 9.7740 mL | 19.5480 mL | 48.8701 mL |
| 5 mM | 0.3910 mL | 1.9548 mL | 3.9096 mL | 9.7740 mL | |
| 10 mM | 0.1955 mL | 0.9774 mL | 1.9548 mL | 4.8870 mL | |
| 15 mM | 0.1303 mL | 0.6516 mL | 1.3032 mL | 3.2580 mL | |
| 20 mM | 0.0977 mL | 0.4887 mL | 0.9774 mL | 2.4435 mL | |
| 25 mM | 0.0782 mL | 0.3910 mL | 0.7819 mL | 1.9548 mL | |
| 30 mM | 0.0652 mL | 0.3258 mL | 0.6516 mL | 1.6290 mL | |
| 40 mM | 0.0489 mL | 0.2444 mL | 0.4887 mL | 1.2218 mL | |
| 50 mM | 0.0391 mL | 0.1955 mL | 0.3910 mL | 0.9774 mL | |
| 60 mM | 0.0326 mL | 0.1629 mL | 0.3258 mL | 0.8145 mL | |
| 80 mM | 0.0244 mL | 0.1222 mL | 0.2444 mL | 0.6109 mL | |
| 100 mM | 0.0195 mL | 0.0977 mL | 0.1955 mL | 0.4887 mL |
Azido-PEG9-acid Related Classifications
HY-130475 Related Classifications
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