2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. 상품명 CAS No. Purity 화학구조
  • HY-140431
    t-Boc-Aminooxy-PEG2-azide 252378-68-0
    t-Boc-Aminooxy-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. t-Boc-Aminooxy-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    t-Boc-Aminooxy-PEG2-azide
  • HY-153153
    Benzyl-PEG45-alcohol 26403-74-7 98.56%
    Benzyl-PEG45-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG45-alcohol
  • HY-133467
    Methyltetrazine-PEG5-methyltetrazine 98.52%
    Methyltetrazine-PEG5-methyltetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Methyltetrazine-PEG5-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    Methyltetrazine-PEG5-methyltetrazine
  • HY-138336
    Br-PEG3-MS 2702323-73-5
    Br-PEG3-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Br-PEG3-MS
  • HY-130525
    Iodo-PEG3-N3 936917-36-1
    Iodo-PEG3-N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Iodo-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Iodo-PEG3-N3
  • HY-W013664
    Glycyl-l-serine 7361-43-5 99.71%
    Glycyl-l-serine is a PROTAC linker composed of glycine and serine. Glycyl-l-serine can be used in the synthesis of PROTACs, such as FPP29 (HY-P11228).
    Glycyl-l-serine
  • HY-141371
    Bromo-PEG2-CH2-Boc 1807518-63-3
    Bromo-PEG2-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG2-CH2-Boc
  • HY-140974
    Mal-amido-PEG12-acid 2378428-27-2 99.32%
    Mal-amido-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG12-acid
  • HY-140575
    N-Mal-N-bis(PEG4-NH-Boc) 2128735-27-1
    N-Mal-N-bis(PEG4-NH-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-Mal-N-bis(PEG4-NH-Boc)
  • HY-133372
    DBCO-NHCO-PEG2-maleimide 2698339-31-8
    DBCO-NHCO-PEG2-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-NHCO-PEG2-maleimide is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-NHCO-PEG2-maleimide
  • HY-133052
    Hydroxy-PEG3-acid 518044-49-0
    Hydroxy-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG3-acid
  • HY-122702
    PEG6-(CH2CO2H)2 77855-76-6
    PEG6-(CH2CO2H)2 is a symmetric PEG PROTAC linker, for the synthesis of Homo-PROTACs which is bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.
    PEG6-(CH2CO2H)2
  • HY-W002680
    (2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 114676-69-6 99.96%
    N-Boc-cis-4-hydroxy-D-proline methyl ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-D-proline methyl ester is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1
    (2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate
  • HY-W096107
    Benzyl-PEG8-alcohol 477775-73-8 99.82%
    Benzyl-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG8-alcohol
  • HY-42618
    Azido-PEG4-CH2-Boc 864681-04-9
    Azido-PEG4-CH2-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG4-CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-CH2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-CH2-Boc
  • HY-130475
    Azido-PEG9-acid 1670249-37-2
    Azido-PEG9-acid is a non-cleavable 9 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG9-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Azido-PEG9-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG9-acid
  • HY-140821
    Bromo-PEG4-azide 1951439-37-4 98.14%
    Bromo-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromo-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Bromo-PEG4-azide
  • HY-45018
    Tos-PEG3-CH2COOtBu 1530778-24-5 98.63%
    Tos-PEG3-CH2COOtBu is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tos-PEG3-CH2COOtBu
  • HY-130662
    Hydroxy-PEG8-Boc 1334177-84-2 99.8%
    Hydroxy-PEG8-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Hydroxy-PEG8-Boc
  • HY-141359
    (2-Pyridyldithio)-PEG4-alcohol 851961-99-4 98.85%
    (2-Pyridyldithio)-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    (2-Pyridyldithio)-PEG4-alcohol
PROTAC Linkers Isoform Comparison

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