DBCO-NHCO-PEG2-maleimide

Name: DBCO-NHCO-PEG2-maleimide
Brand: MedChemExpress
SKU: HY-133372
Rating: 4.5 (0 reviews)

Cat. No.: HY-133372 Pureza: 97.67%: Ficha de datos
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DBCO-NHCO-PEG2-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-NHCO-PEG2-maleimide is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

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DBCO-NHCO-PEG2-maleimide Estructura química

No. CAS : 2698339-31-8

Tamaño	Stock	Cantidad
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	Obtener un presupuesto	Estimated Time of Arrival: December 31
100 mg	Obtener un presupuesto
200 mg	Obtener un presupuesto

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Based on 1 Customer Validation

Other Forms of DBCO-NHCO-PEG2-maleimide:

DBCO-PEG3-Maleimide In-stock

Recomendaciones destacadas

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas PROTAC Linkers:

Ver todas las isoformas

PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Actividad biológica
Pureza y Documentación
Referencias
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Descripciòn

DBCO-NHCO-PEG2-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. DBCO-NHCO-PEG2-maleimide is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

586.63

Fòrmula

C₃₂H₃₄N₄O₇

No. CAS

2698339-31-8

Appearance

Solid

Color

Yellow to brown

SMILES

O=C(CCNC(CCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)=O)N2C3=CC=CC=C3C#CC4=CC=CC=C4C2

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureza y Documentación

Purity: 97.67%

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Ficha de datos (265 KB) SDS (393 KB)

COA (244 KB) HNMR (282 KB) LCMS (88 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]