2. Signaling Pathways
  3. GPCR/G Protein
  4. Arrestin
  5. Arrestin-2/β-Arrestin 1 Isoform
  6. Arrestin-2/β-Arrestin 1 Inhibitor

Arrestin-2/β-Arrestin 1 Inhibitor

Arrestin-2/β-Arrestin 1 Inhibitors (2):

Cat. No. Product Name Effect Purity
  • HY-120925
    TRV0109101
    		Inhibitor
    TRV0109101 is a μ-opioid peptide receptor (MOPR) selective agonist (KD = 70 nM) with blood-brain barrier permeability. TRV0109101 selectively promotes G protein signaling pathway coupling while reducing the recruitment of β-arrestin. TRV0109101 inhibits opioid-induced mechanical hyperalgesia and induces antinociceptive tolerance. TRV0109101 is applicable for pain-related research.
  • HY-183777
    B-007
    		Inhibitor
    B-007 is an AplnR agonist with G protein-biased signaling (EC50 = 11.6 nM). B-007 activates the G protein pathway while abolishing β-arrestin1 and β-arrestin2 signaling. B-007 serves as a scaffold for development of G protein-biased apelin receptor agonists. B-007 can be used for the research of heart failure.