B-007 

B-007 is an AplnR agonist with G protein-biased signaling (EC₅₀ = 11.6 nM). B-007 activates the G protein pathway while abolishing β-arrestin1 and β-arrestin2 signaling. B-007 serves as a scaffold for development of G protein-biased apelin receptor agonists. B-007 can be used for the research of heart failure^[1].

B-007 potently activates the AplnR G protein pathway in cell systems expressing the Apelin receptor (AplnR), with an EC₅₀ of 11.6 nM and an E_max of 118.0%^[1].
B-007 completely fails to activate the β-arrestin1 or β-arrestin2 pathways of the AplnR in AplnR-expressing cell systems, thereby exhibiting prominent G protein-biased characteristics^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

717.62

C₃₂H₂₄F₅N₅O₇S

COC1=CC=CC(OC)=C1C2=NC(C(NS(C(C3=CC=CC=C3)COC(C4=C(F)C(F)=C(F)C(F)=C4F)=O)(=O)=O)=O)=NN2C5=CN=CC(C)=C5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Shen C, et al. Design, synthesis, and biological evaluation of 1H-1,2,4-triazole-3-carboxamides as apelin receptor agonists. Bioorganic & Medicinal Chemistry Letters. 2026;138:130685.