Calmodulin
Calmodulin; CaM; Calcium-Modulated Protein
Calmodulin is the highly conserved, calcium-sensitive protein, that acts as the calcium ion sensor in cells, Ca2+-dependently binds to target proteins, and converts Ca2+ concentrations into cellular signals. Calmodulin has four different Ca2+ binding sites named EF-hand for the sensing of Ca2+ signaling with different amplitude, duration, and location. Calmodulin dysfunction could lead to myocardial contractile problems, neuronal damage, or tumor angiogenesis dysregulation, which may cause cardiovascular diseases, neurological diseases, or cancer[1][2][3].
References:
- [1]. Means AR, et al., Calmodulin--an intracellular calcium receptor. Nature. 1980 May 8;285(5760):73-7. doi: 10.1038/285073a0 [Content Brief]
- [2]. Kawasaki H, et al., Molecular Dynamics Study of the Changes in Conformation of Calmodulin with Calcium Binding and/or Target Recognition. Sci Rep. 2019 Jul 23;9(1):10688. [Content Brief]
- [3]. Crotti L, et al., Clinical presentation of calmodulin mutations: the International Calmodulinopathy Registry. Eur Heart J. 2023 Sep 14;44(35):3357-3370. [Content Brief]
Calmodulin Isoform Specific Products
All Product Categories
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Calmodulin Related Products (59)
Related Products (59)
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Antibodies (4)
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Calmodulin Isoform Comparison
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CALP1
0 ImagesCALP1 is a calmodulin (CaM) agonist (Kd of 88 µM) with binding to the CaM EF-hand/Ca2+-binding site. CALP1 blocks calcium influx and apoptosis (IC50 of 44.78 µM) through inhibition of calcium channel opening. CALP1 blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 activates CaM-dependent phosphodiesterase activity.
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Albanin A
0 ImagesCat. No.: HY-N10772CAS No.: 73343-42-7Albanin A, a flavonoid, suppresses glutamate release by decreasing Ca2+/calmodulin/adenylate Cyclase 1 (AC1) activation in synaptosomes and exerts neuroprotective effect in vivo. Albanin A has anti-inflflammatory activity.
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A-7 hydrochloride
0 ImagesSynonyms: Ophobolin AA-7 hydrochloride (Ophobolin A) is a calmodulin antagonist and can be used for the research of cancer.
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Metofenazate
0 ImagesMetofenazate is a selective calmodulin inhibitor.
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Calmodulin antagonist-1
0 ImagesCalmodulin antagonist-1 (A-5) is a calmodulin (CaM) antagonist. Calmodulin antagonist-1 inhibits calmodulin-activated Ca2+-phosphodiesterase (PDE) (IC50=66 μM). Calmodulin antagonist-1 also inhibits trypsin-treated Ca2+-PDE (IC50=560 μM) in a competitive fashion with respect to cyclic GMP.
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L-6355
0 ImagesCat. No.: HY-124176CAS No.: 85642-08-6L-6355 is an Amiodarone (HY-14187) related compound, which inhibits Ca2+/calmodulin activated cyclic nucleotide phosphodiesterase with an IC50 value of 0.65 μM. L-6355 is promising for research of antiarrhythmic and antianginal agent.
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CBP-501
0 ImagesCat. No.: HY-16129CAS No.: 565434-85-7CBP-501, a cell-permeable calmodulin-binding peptide and a G2-abrogating drug candidate, inhibits the activity of multiple Ser216-specific kinases, such as MAPKAP-K2, C-Tak1, CHK1 and CHK2, with IC50 values of 0.9 μM, 1.4 μM 3.4 μM and 6.5 μM, respectively. CBP-501 is used for various types of cancer.
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E6 Berbamine
0 ImagesCat. No.: HY-120997CAS No.: 114784-59-7Synonyms: Berbamine p-nitrobenzoateE6 Berbamine (Berbamine p-nitrobenzoate) is a potent calmodulin (CaM) antagonist. E6 Berbamine inhibits the activities of calmodulin-dependent myosin light chain kinase (MLCK) and phosphodiesterase (PDE). E6 Berbamine exhibits anti-leukemic activity. E6 Berbamine can be used in research related to cardiovascular abnormalities and chronic myeloid leukemia.
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Zaldaride
0 ImagesCat. No.: HY-105118CAS No.: 109826-26-8Synonyms: CGS-9343B free base; KW 5617 free baseZaldaride (CGS-9343B free base) is a potent, orally active and selective inhibitor of calmodulin. Zaldaride inhibits CaM (calmodulin)-stimulated cAMP phosphodiesterase activity, with an IC50 of 3.3 nM. Zaldaride prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na+, Ca2+ and K+ currents in PC12 cells and inhibits nAChR.
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CALM1 Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS01840CALM1 Human Pre-designed siRNA Set A contains three designed siRNAs for CALM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Components
CALM1 siRNA-1: 5 nmol (HPLC)
CALM1 siRNA-2: 5 nmol (HPLC)
CALM1 siRNA-3: 5 nmol (HPLC)
siRNA Negative Control: 5 nmol (HPLC)
FAM-labeled siRNA Negative Control: 5 nmol (HPLC)
GAPDH siRNA Positive Control: 5 nmol (HPLC)
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Bovine calmodulin
0 ImagesCat. No.: HY-NP0230Bovine calmodulin can be used for the in vitro phosphorylation assay of recombinant retinoic acid-induced gene I protein. Bovine calmodulin has also been used in studies of the hydrolysis and deamidation of the endopeptide Glu-C protein.
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KS 501
0 ImagesCat. No.: HY-117232CAS No.: 120634-86-8KS 501 is a potent and selective calmodulin inhibitor. KS 501 inhibits the activation of calmodulin kinase I and II, but has less effect against cyclic adenosine 3’,5’-monophosphate (cyclic AMP)-sensitive kinase. KS 501 inhibits the enzyme through interfering with calmodulin activation rather than through a direct effect on the enzyme. KS 501 can be used for the study of leukemia.
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CALP2
0 ImagesCat. No.: HY-P1076CAS No.: 261969-04-4CALP2 is a calmodulin (CaM) antagonist ( (Kd of 7.9 µM)) with high affinity for binding to the CaM EF-hand/Ca2+-binding site. CALP2 inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca2+ concentrations. CALP2 potently inhibits of adhesion and degranulation. CALP2 is also a strong activator of alveolar macrophages.
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Acremonidin A
0 ImagesCat. No.: HY-N10198CAS No.: 701914-77-4Acremonidin A is a potent calmodulin (CaM) inhibitor found in Purpureocillium lilacinum. Acremonidin A binds to the human calmodulin (hCaM) biosensor hCaM M124C-mBBr, with Kd of 19.40 nM.
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CBP-501 acetate
0 ImagesCat. No.: HY-16129APurity: 99.75%CBP-501 acetate, a cell-permeable calmodulin-binding peptide and a G2-abrogating drug candidate, inhibits the activity of multiple Ser216-specific kinases, such as MAPKAP-K2, C-Tak1, CHK1 and CHK2, with IC50 values of 0.9 μM, 1.4 μM 3.4 μM and 6.5 μM, respectively. CBP-501 acetate is used for various types of cancer.
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DY-9760e
0 ImagesCat. No.: HY-19230CAS No.: 179185-73-0DY-9760e is a calmodulin (CaM) inhibitor. DY-9760e selectively inhibits the activity of various calmodulin-dependent enzymes by antagonizing the Ca²⁺/CaM complex, exhibiting the strongest inhibitory activity against nNOS, CaM kinase II, and calcineurin (Ki: 0.9, 1.4, and 2.0 μM, respectively). DY-9760e inhibits excessive nitric oxide production and protein tyrosine nitration, as well as the activation of calpain and caspase-3. DY-9760e reduces infarct size, improves cardiac function, and inhibits oxidative stress and cell death. DY-9760e can be used in research on the treatment of myocardial infarction, cerebral ischemia, and other diseases.
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Beauverolide Ja
0 ImagesCat. No.: HY-142087CAS No.: 76265-41-3Beauverolide Ja, a cyclotetradepsipeptide, is a potent calmodulin (CaM) inhibitor with a Kd of 0.078 μM and a Ki of 0.39 μM for Ca2+-CaM. Beauverolide Ja is a secondary metabolite of Isaria fumosorosea.
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RU 45144
0 ImagesCat. No.: HY-118242CAS No.: 119286-92-9RU 45144 is an anti-estrogen compound that has the activity of antagonizing the binding of estrogen receptors to calmodulin. RU 45144 can inhibit the binding of estrogen receptors to calmodulin, and its effect is similar to that of tamoxifen. Its anti-estrogen effect may be related to specific side chains in the molecular structure, and the steroid skeleton may be involved in its anti-proliferative activity.
