Calmodulin

Calmodulin; CaM; Calcium-Modulated Protein

Calmodulin is the highly conserved, calcium-sensitive protein, that acts as the calcium ion sensor in cells, Ca²⁺-dependently binds to target proteins, and converts Ca²⁺ concentrations into cellular signals. Calmodulin has four different Ca²⁺ binding sites named EF-hand for the sensing of Ca²⁺ signaling with different amplitude, duration, and location. Calmodulin dysfunction could lead to myocardial contractile problems, neuronal damage, or tumor angiogenesis dysregulation, which may cause cardiovascular diseases, neurological diseases, or cancer^[1]^[2]^[3].

References:

[1]. Means AR, et al., Calmodulin--an intracellular calcium receptor. Nature. 1980 May 8;285(5760):73-7. doi: 10.1038/285073a0 [Content Brief]

[2]. Kawasaki H, et al., Molecular Dynamics Study of the Changes in Conformation of Calmodulin with Calcium Binding and/or Target Recognition. Sci Rep. 2019 Jul 23;9(1):10688. [Content Brief]

[3]. Crotti L, et al., Clinical presentation of calmodulin mutations: the International Calmodulinopathy Registry. Eur Heart J. 2023 Sep 14;44(35):3357-3370. [Content Brief]

Calmodulin Isoform Specific Products:

Calmodulin Isoform Comparison

Calmodulin Related Products (57)
Antibodies (4)
Calmodulin Isoform Comparison

By Effects:	Inhibitors (23) Agonists (2) Ligand (1) Antagonists (21)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-N10772

Albanin A	Inhibitor
Albanin A, a flavonoid, suppresses glutamate release by decreasing Ca²⁺/calmodulin/adenylate Cyclase 1 (AC1) activation in synaptosomes and exerts neuroprotective effect in vivo. Albanin A has anti-inflflammatory activity.

HY-100914

A-7 hydrochloride	Antagonist	99.09%
A-7 hydrochloride (Ophobolin A) is a calmodulin antagonist and can be used for the research of cancer.

HY-100263

Metofenazate	Inhibitor	98.73%
Metofenazate is a selective calmodulin inhibitor.

HY-115745

Calmodulin antagonist-1	Antagonist	98.0%
Calmodulin antagonist-1 (A-5) is a calmodulin (CaM) antagonist. Calmodulin antagonist-1 inhibits calmodulin-activated Ca²⁺-phosphodiesterase (PDE) (IC₅₀=66 μM). Calmodulin antagonist-1 also inhibits trypsin-treated Ca²⁺-PDE (IC₅₀=560 μM) in a competitive fashion with respect to cyclic GMP.

HY-19015

Probimane	Inhibitor	99.91%
Probimane (AT-2153) is a potent anticancer agent. Probimane is effective against mouse tumors S37, S180, Lewis lung carcinoma, L1210 and human pulmonary adenocarcinoma heterotransplanted into nude mice.

HY-16129

CBP-501		99.75%
CBP-501, a cell-permeable calmodulin-binding peptide and a G2-abrogating drug candidate, inhibits the activity of multiple Ser²¹⁶-specific kinases, such as MAPKAP-K2, C-Tak1, CHK1 and CHK2, with IC₅₀ values of 0.9 μM, 1.4 μM 3.4 μM and 6.5 μM, respectively. CBP-501 is used for various types of cancer.

HY-P2471

Neurogranin (48-76), mouse	Inhibitor
Neurogranin (48-76), mouse is a peptide corresponding to residues 48-76 of Neurogranin. Neurogranin, a calmodulin-binding protein, is exclusively expressed in the post-synapse, and mediates NMDAR driven synaptic plasticity by regulating the calcium-calmodulin (Ca²⁺-CaM) pathway.

HY-120997

E6 Berbamine	Antagonist
E6 Berbamine (Berbamine p-nitrobenzoate) is a potent calmodulin (CaM) antagonist. E6 Berbamine inhibits the activities of calmodulin-dependent myosin light chain kinase (MLCK) and phosphodiesterase (PDE). E6 Berbamine exhibits anti-leukemic activity. E6 Berbamine can be used in research related to cardiovascular abnormalities and chronic myeloid leukemia.

HY-105118

Zaldaride	Inhibitor
Zaldaride (CGS-9343B free base) is a potent, orally active and selective inhibitor of calmodulin. Zaldaride inhibits CaM (calmodulin)-stimulated cAMP phosphodiesterase activity, with an IC₅₀ of 3.3 nM. Zaldaride prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na⁺, Ca²⁺ and K⁺ currents in PC12 cells and inhibits nAChR.

HY-RS01840

CALM1 Human Pre-designed siRNA Set A
CALM1 Human Pre-designed siRNA Set A contains three designed siRNAs for CALM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control. Components CALM1 siRNA-1: 5 nmol (HPLC) CALM1 siRNA-2: 5 nmol (HPLC) CALM1 siRNA-3: 5 nmol (HPLC) siRNA Negative Control: 5 nmol (HPLC) FAM-labeled siRNA Negative Control: 5 nmol (HPLC) GAPDH siRNA Positive Control: 5 nmol (HPLC)

CALM1 Human Pre-designed siRNA Set A

CALM1 Human Pre-designed siRNA Set A contains three designed siRNAs for CALM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Components

CALM1 siRNA-1: 5 nmol (HPLC)

CALM1 siRNA-2: 5 nmol (HPLC)

CALM1 siRNA-3: 5 nmol (HPLC)

siRNA Negative Control: 5 nmol (HPLC)

FAM-labeled siRNA Negative Control: 5 nmol (HPLC)

GAPDH siRNA Positive Control: 5 nmol (HPLC)

HY-NP0230

Bovine calmodulin
Bovine calmodulin can be used for the in vitro phosphorylation assay of recombinant retinoic acid-induced gene I protein. Bovine calmodulin has also been used in studies of the hydrolysis and deamidation of the endopeptide Glu-C protein.

HY-P1076

CALP2	Antagonist
CALP2 is a calmodulin (CaM) antagonist ( (K_d of 7.9 µM)) with high affinity for binding to the CaM EF-hand/Ca²⁺-binding site. CALP2 inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca²⁺ concentrations. CALP2 potently inhibits of adhesion and degranulation. CALP2 is also a strong activator of alveolar macrophages.

HY-N10198

Acremonidin A	Inhibitor
Acremonidin A is a potent calmodulin (CaM) inhibitor found in Purpureocillium lilacinum. Acremonidin A binds to the human calmodulin (hCaM) biosensor hCaM M124C-mBBr, with K_d of 19.40 nM.

HY-16129A

CBP-501 acetate		99.75%
CBP-501 acetate, a cell-permeable calmodulin-binding peptide and a G2-abrogating drug candidate, inhibits the activity of multiple Ser²¹⁶-specific kinases, such as MAPKAP-K2, C-Tak1, CHK1 and CHK2, with IC₅₀ values of 0.9 μM, 1.4 μM 3.4 μM and 6.5 μM, respectively. CBP-501 acetate is used for various types of cancer.

HY-19230

DY-9760e	Inhibitor
DY-9760e is a calmodulin (CaM) inhibitor. DY-9760e selectively inhibits the activity of various calmodulin-dependent enzymes by antagonizing the Ca²⁺/CaM complex, exhibiting the strongest inhibitory activity against nNOS, CaM kinase II, and calcineurin (K_i: 0.9, 1.4, and 2.0 μM, respectively). DY-9760e inhibits excessive nitric oxide production and protein tyrosine nitration, as well as the activation of calpain and caspase-3. DY-9760e reduces infarct size, improves cardiac function, and inhibits oxidative stress and cell death. DY-9760e can be used in research on the treatment of myocardial infarction, cerebral ischemia, and other diseases.

HY-124176

L-6355	Antagonist
L-6355 is an Amiodarone (HY-14187) related compound, which inhibits Ca²⁺/calmodulin activated cyclic nucleotide phosphodiesterase with an IC₅₀ value of 0.65 μM. L-6355 is promising for research of antiarrhythmic and antianginal agent.

HY-142087

Beauverolide Ja	Inhibitor
Beauverolide Ja, a cyclotetradepsipeptide, is a potent calmodulin (CaM) inhibitor with a K_d of 0.078 μM and a K_i of 0.39 μM for Ca²⁺-CaM. Beauverolide Ja is a secondary metabolite of Isaria fumosorosea.

HY-118242

RU 45144	Antagonist
RU 45144 is an anti-estrogen compound that has the activity of antagonizing the binding of estrogen receptors to calmodulin. RU 45144 can inhibit the binding of estrogen receptors to calmodulin, and its effect is similar to that of tamoxifen. Its anti-estrogen effect may be related to specific side chains in the molecular structure, and the steroid skeleton may be involved in its anti-proliferative activity.

HY-N12411

(S)-O-Methylencecalinol	Inhibitor
(S)-O-Methylencecalinol (compound 10) is a calmodulin-targeting molecule isolated from the aerial parts of Ageratina grandifolia.

HY-N12405

Encecalinol	Inhibitor
Encecalinol, extracted from aerial parts of Ageratina grandifolia, is a potent inhibitor of calmodulin inhibitor.

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Calmodulin

Calmodulin Isoform Specific Products:

Calmodulin Isoform Specific Products:

Calmodulin Related Products (57)

Antibodies (4)

Calmodulin Isoform Comparison

Calmodulin Related Products (57):