1. Membrane Transporter/Ion Channel
  2. Calmodulin
  3. CV-159

CV-159 is a unique dihydropyridine Ca2+ antagonist with an anti-calmodulin (CaM) action, and has antiinflammatory activities.

For research use only. We do not sell to patients.

CV-159 Chemical Structure

CV-159 Chemical Structure

CAS No. : 86384-98-7

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Description

CV-159 is a unique dihydropyridine Ca2+ antagonist with an anti-calmodulin (CaM) action, and has antiinflammatory activities.

In Vitro

CV-159 (0.1-10 μM) significantly inhibits TNF-α (10 ng/ml, 24 h)-induced VCAM-1 in SMCs in a concentrationdependent manner. CV-159 (10 μM, 30 min) significantly inhibits the TNF-induced ROS production[1]. CV-159 (10 μM) inhibits TNF (24 h)-induced expression of e-selectin but not vascular cell adhesion molecule-1 and intercellular adhesion molecule-1. CV-159 inhibits TNF (20 min)-induced phosphorylation of JNK, p38, and NF-κB p65 (Ser536)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CV-159 (5 and 10 mg/kg, p.o.) gives significant protection against delayed neuronal death in the hippocampal CA1 region of the rats after 15-min transient forebrain ischemia. CV-159 also diminishes the size of the brain infarct after permanent middle cerebral artery (MCA) occlusion. CV-159 significantly reduces the increase in the water content of the infarcted cortex induced by MCA occlusion[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

574.62

Formula

C31H34N4O7

CAS No.
SMILES

O=C(C1=C(C)NC(C)=C(C(OCCCCCCOC2=NNC(C3=CC=CC=C3)=C2)=O)C1C4=CC=CC([N+]([O-])=O)=C4)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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References
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CV-159 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
CV-159
Cat. No.:
HY-19025
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