Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Related Products (4062)
Related Products (4062)
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Vitamin A Propionate
0 ImagesVitamin A Propionate is an ester compound of vitamin A. In nutritional studies of foals, different doses have different effects on growth, serum biochemistry and hematological indicators. Too high or too low doses will produce adverse effects and are related to the vitamin A concentration in plasma, liver and kidneys.
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4,4'-Sulfonyldiphenol (Standard)
0 ImagesSynonyms: Bisphenol S (Standard); Bis(4-hydroxyphenyl) sulfone (Standard)4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone) (Standard) is the analytical standard of 4,4'-Sulfonyldiphenol (HY-W011927). This product is intended for research and analytical applications. 4,4'-Sulfonyldiphenol, a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC50 values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae.
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1,2-Dioleoyl-3-arachidoylglycerol
0 Images1,2-Dioleoyl-3-arachidoylglycerol (AOO) is a triacylglycerol that can be isolated from soybean oil.
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(1′S,2′S)-Nicotine-1'-oxide-d3
0 ImagesCat. No.: HY-N8723SPurity: 99.76%(1′S,2′S)-Nicotine-1'-oxide-d3 is the d3-labeled (1′S,2′S)-Nicotine-1'-oxide (HY-N8723). (1′S,2′S)-Nicotine-1'-oxide is a nicotine derivative and also a non/weakly potent α3β4 neuronal nicotinic acetylcholine receptor (nAChR) ligand.
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Dimesna
0 ImagesSynonyms: BNP-7787Dimesna (BNP-7787), the disulfide form of Mesna (HY-13679), is a platinum-related toxicity protective agent. Dimesna converts to Mesna, which in turn inactivates toxic platinum substances. Dimesna does not interfere with the antitumor activity of platinum compounds. Dimesna does not affect the antiproliferative effects of Cisplatin (HY-17394) or Carboplatin (HY-17393). Dimesna counteracts Cisplatin-induced nephrotoxicity. Dimesna exerts selective protective effects on the kidneys. Dimesna can be used in studies related to ovarian cancer and Cisplatin-induced nephrotoxicity.
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(-)-Epigallocatechin-3-O-(4-O-methyl)gallate
0 ImagesSynonyms: EGCG4′′Me(-)-Epigallocatechin-3-O-(4-O-methyl)gallate is an orally active catechin derivative found in Taiwanese oolong tea. (-)-Epigallocatechin-3-O-(4-O-methyl)gallate can inhibit histamine release and exhibits anti-inflammation and anti-allergic effect. (-)-Epigallocatechin-3-O-(4-O-methyl)gallate can be used for the researches of immunology and inflammation, such as type I allergic.
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Para-nitrophenyl oleate
0 ImagesPara-nitrophenyl oleate is an ester product.
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Monomethyl itaconate
0 ImagesSynonyms: β-Methyl itaconateMonomethyl itaconate (β-Methyl itaconate) is a monomethyl ester derivative of Itaconic acid (HY-Y0520). Monomethyl itaconate can copolymerize with PEGMA to form pH-sensitive hydrogels.
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Senkyunolide N
0 ImagesSenkyunolide N, a phthalide, can be isolated from rhizome of Ligusticum Chuanxiong.
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Monostearyl maleate
0 ImagesSynonyms: Octadecyl fumarateMonostearyl maleate (Octadecyl fumarate) is a monomeric lipid synthesized from maleic anhydride and stearyl alcohol. Monostearyl maleate can be found in the ethanol extract of Citrullus colocynthis fruits. Monostearyl maleate can be used to prepare terpolymers for application as a viscosity reducer for heavy oil.
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2,5-Dihydroxybenzoic acid sodium
0 ImagesSynonyms: Gentisic acid sodium2,5-Dihydroxybenzoic acid (sodium) (Gentisic acid (sodium)) is a phenolic compound. 2,5-Dihydroxybenzoic acid (sodium) restores mean arterial pressure and reduces blood lactate concentration in animal models of sepsis and septic shock. 2,5-Dihydroxybenzoic acid (sodium) can be used in the study of septic shock related diseases.
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C24 Glucosyl(β) ceramide (d18:1/24:0)
0 ImagesC24 Glucosyl(β) ceramide (d18:1/24:0), C24-Ceramide (d18:1/24:0) (HY-134508A) derivative, is a β-glucosyl ceramide and can be used for the research of lipid.
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Henicosan-11-ol
0 ImagesSynonyms: 11-HeneicosanolHenicosan-11-ol (11-Heneicosanol) is an ester product.
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Inositol nicotinate (Standard)
0 ImagesSynonyms: Inositol niacinate (Standard); Hexanicit (Standard)Inositol nicotinate (Standard) is the analytical standard of Inositol nicotinate. This product is intended for research and analytical applications. Inositol nicotinate, with vasodilatory effect, is used in the study of Peripheral arterial disease (PAD).
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2-Oxovaleric acid (Standard)
0 ImagesCat. No.: HY-113098RCAS No.: 1821-02-92-Oxovaleric acid (Standard) is the analytical standard of 2-Oxovaleric acid (HY-113098). This product is intended for research and analytical applications. 2-Oxovaleric acid is an analog of Pyruvate and a substrate inhibitor of Lactate dehydrogenase, exhibiting substrate inhibitory activity against lactate dehydrogenase from Phycomyces blakesleeanus.
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Sissotrin
0 ImagesSissotrin (Biochanin A 7-glucoside; Sissonin) is an orally active isoflavone glycoside natural product found in Leguminosae plants, with weak antibacterial activity. Sissotrin exacerbates the increase in blood glucose after glucose loading. Sissotrin is used in studies related to glucose metabolism.
