2. Signaling Pathways
  3. Others
  4. Drug Derivative
  5. Drug Derivative Inhibitor

Drug Derivative Inhibitor

Drug Derivative Inhibitors (11):

Cat. No. Product Name Effect Purity
  • HY-13631J
    (1R,9R)-Exatecan mesylate
    		Inhibitor 99.49%
    (1R,9R)-Exatecan mesylate ((1R,9R)-DX8951f) is a non-prodrug camptothecin derivative and a potent topoisomerase I inhibitor (IC50=0.975 μg/mL in mice and 0.82 μg/mL in humans). (1R,9R)-Exatecan mesylate blocks enzyme activity and induces apoptosis by stabilizing the enzyme-DNA cleavable complex. (1R,9R)-Exatecan mesylate not only effectively inhibits the proliferation of various malignant tumor cells and tumor growth, but also circumvents P-glycoprotein-mediated multidrug resistance. (1R,9R)-Exatecan mesylate is widely used in preclinical studies of multiple cancers including pancreatic cancer, lung cancer, breast cancer, and leukemia. The low-activity isomer of (1R,9R)-Exatecan mesylate is (1S,9R)-Exatecan mesylate (HY-13631I).
  • HY-168981
    Larubrilstat
    		Inhibitor 98.89%
    Larubrilstat is a vascular non-inflammatory molecule-1 (VNN1) inhibitor.
  • HY-15961
    Antitumor agent-3
    		Inhibitor 99.89%
    Antitumor agent-3 is a potent compound which comprises a new imidazopyridine having excellent antitumor activity as an active ingredient.
  • HY-105514
    KP-10614
    		Inhibitor
    KP-10614 is a potent, orally active platelet aggregation inhibitor. KP-10614 inhibits platelet aggregation induced by ADP with IC50 of 1 nM. KP-10614 causes dose-dependent inhibition of ex vivo platelet aggregation in rats. KP-10614 shows antithrombotic effects in various thrombosis models. KP-10614 can be used for thrombotic diseases research.
  • HY-N16498
    Kaempferol 3-rungioside
    		Inhibitor
    Kaempferol 3-rungioside is a glycoside derivative of Kaempferol (HY-14590).
  • HY-160871
    Anticancer agent 208
    		Inhibitor
    Anticancer agent 208 (C014) is an anticancer agent that can be used to inhibit cancer or prevent its recurrence.
  • HY-163629
    Anticancer agent 224
    		Inhibitor
    Anticancer agent 224 (Compound 16) is an anticancer agent that can effectively inhibit the growth of central nervous system (CNS), kidney and breast cancer cell, with a GI50 value ranging from 0.6 to 12.8 μM.
  • HY-115389
    Argimesna ethanesulfonate
    		Inhibitor
    Argimesna ethanesulfonate is a uroprotective agent. Argimesna ethanesulfonate is promising for research of hemorrhagic cystitis in cancer chemotherapy.
  • HY-170801
    Anticonvulsant agent 7
    		Inhibitor
    Anticonvulsant agent 7 (Compound 19) is an orally active broad-spectrum anticonvulsant that demonstrates excellent anticonvulsive activity in both the MES (maximal electroshock seizure) and 6 Hz epilepsy modelsmouse.
  • HY-W187463
    2-Mercaptopyridin-3-ol
    		Inhibitor
    2-Mercaptopyridin-3-ol (3-HPT) is a natural product with strong metal coordination ability. 2-Mercaptopyridin-3-ol can be used as a metal enzyme inhibitor.
  • HY-W243244
    β-Ionone acid
    		Inhibitor 98.78%
    β-Ionone acid, an analog of β-Ionone, is a promising anticancer agent.