2. Signaling Pathways
  3. Others
  4. Drug Derivative

Drug Derivative

Drug derivative

Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.

Drug Derivative Related Products (3818):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N16887
    Eucalyptin acetate
    Eucalyptin acetate is a natural flavonoid.
    Eucalyptin acetate
  • HY-W343043
    Pyrazinoylguanidine
    Pyrazinoylguanidine (PZG) is an analogue of the potassium sparing diuretic, Amiloride (HY-B0285). Pyrazinoylguanidine can lower the systolic and diastolic blood pressure of patients with primary hypertension, has a certain effect on reducing heart rate, and does not affect the concentrations of electrolytes such as sodium, potassium, and chloride in the blood serum. Pyrazinoylguanidine can reduce the hyperglycemia and hyperinsulinemia in type 2 diabetes, reduce the levels of triglycerides, cholesterol, and free fatty acids, and reverse the hyperglycemia and hyperlipidemia induced by thiazide diuretics, such as Hydrochlorothiazide (HY-B0252). Pyrazinoylguanidine ican nhibit the reabsorption of urea by the renal tubules, thereby increasing the clearance rate and excretion volume of urea, reducing the serum urea concentration, and minimizing its toxic accumulation.
    Pyrazinoylguanidine
  • HY-19068
    FO-152 monohydrochloride
    FO-152 monohydrochloride is a derivative of 5-Fluorouridine (HY-107856). FO-152 monohydrochloride exhibits more favorable antitumor activity and lower toxicity.
    FO-152 monohydrochloride
  • HY-N17234
    21,23-Dihydro-21-hydroxy-23-oxonomilin
    21,23-Dihydro-21-hydroxy-23-oxonomilin is a natural triterpene.
    21,23-Dihydro-21-hydroxy-23-oxonomilin
  • HY-N18046
    Otophylloside Q
    Otophylloside Q is a pregnane glycoside (C-21 steroidal glycoside) isolated from the roots of Cynanchum otophyllum. With caudatin (HY-N1983), an anticancer agent, as its aglycone, Otophylloside Q contains a sugar chain composed of cymarose, oleandrose and glucose units.
    Otophylloside Q
  • HY-105020
    Derpanicate
    Derpanicate is a Nicotinic acid (HY-B0143) ester. Derpanicate has antihypercholesterolaemic and/or vasodilating effects.
    Derpanicate
  • HY-176938
    AfaPhos1
    AfaPhos1 is a new, Afatinib (HY-10261)-based EGFR PhosTAC. AfaPhos1 induces EGFR dephosphorylation at both pY1068 and pY845. AfaPhos1 induces Apoptosis. AfaPhos1 has anticancer activity against non-small cell lung cancer.
    AfaPhos1
  • HY-133160
    Valproic acid hydroxamate
    Valproic acid hydroxamate (VPA-HA) has shown anticonvulsant activity in a mouse neural tube defect model, without any teratogenic effects.
    Valproic acid hydroxamate
  • HY-131390
    S-Ethylglutathione
    S-Ethylglutathione is a biochemical.
    S-Ethylglutathione
  • HY-N17157
    1β-Hydroxy-8α-methoxyeremophila-7(11),9-dien-12,8β-olide
    1β-Hydroxy-8α-methoxyeremophila-7(11),9-dien-12,8β-olide is a natural sesquiterpene.
    1β-Hydroxy-8α-methoxyeremophila-7(11),9-dien-12,8β-olide
  • HY-N13805
    1-Oxohederagenin
    1-Oxohederagenin is a natural triterpene.
    1-Oxohederagenin
  • HY-N17010
    Quassidine B
    Quassidine B (Dihydropicrasidine A) is a natural alkaloid.
    Quassidine B
  • HY-P992482
    VIR-2482
    VIR-2482 is a monoclonal antibody targeting influenza A hemagglutinin (HA). VIR-2482 is generated by introducing LS mutations (M428L/N434S) into the Fc region of MEDI8852 (HY-P991446). VIR-2482 binds to the conserved HA stem epitope across all 18 influenza A HA subtypes, neutralizes a broad spectrum of H1N1 and H3N2 strains, binds to FcγRIIIa, FcγRIIa and C1q, and induces antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity. VIR-2482 reduces morbidity and mortality caused by seasonal influenza A strains and provides prophylactic protection in mice. VIR-2482 can be used in research related to influenza A disease.
    VIR-2482
  • HY-N17083
    Lucidafuranocoumarin B
    Lucidafuranocoumarin B is a natural coumarin.
    Lucidafuranocoumarin B
  • HY-N7301
    Glabratine
    Glabratine is a natural alkaloid.
    Glabratine
  • HY-N16936
    (Z)-Pinosylvin monomethyl ether
    (Z)-Pinosylvin monomethyl ether is a natural phenolic compound.
    (Z)-Pinosylvin monomethyl ether
  • HY-N13761
    Physaminimin N
    Physaminimin N is a natural steroid.
    Physaminimin N
  • HY-N9864
    Mahanimbinol
    Mahanimbinol is a natural alkaloid.
    Mahanimbinol
  • HY-N17104
    Bisandrographolide G
    Bisandrographolide G is a natural diterpene.
    Bisandrographolide G
  • HY-N16712
    Powelline
    Powelline is a natural alkaloid.
    Powelline