2. Signaling Pathways
  3. Others
  4. Drug Derivative

Drug Derivative

Drug derivative

Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.

Drug Derivative Related Products (3821):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-101701
    Hepronicate
    		99.95%
    Hepronicate, a nicotinic acid derivative, is a peripheral vasodilator with blood lipid lowering action. Hepronicate works by improving peripheral circulatory disturbances.
    Hepronicate
  • HY-A0235
    Antrafenine
    		99.76%
    Antrafenine (Stakane) is a derivative of 2-(quinolin-4-ylamino) benzoate, and is an orally active anti-inflammatory and analgesic agent. Antrafenine protects mammalian epithelial cells from cell death upon exposure to influenza A virus A/WSN/33 (H1N1). Antrafenine inhibits carrageenan-induced paw swelling in rats, and reduces exudate volume and total leukocyte infiltration in carrageenan- and calcium pyrophosphate dihydrate crystal-induced pleurisy in rats. Antrafenine can be used in studies related to influenza and pseudogout.
    Antrafenine
  • HY-W100959
    Duroquinone
    		99.96%
    Duroquinone (Tetramethylquinone) is a model compound of amphiphilic quinone, which can be used as an oxidative-reductive activity probe. Duroquinone can be easily reduced by biological systems to hydrogen peroxide (DQH₂) or semi-quinone free radicals (DQ•⁻). Duroquinone can freely pass through the cell membrane, facilitating the study of the electron transfer process inside and outside the cells. Duroquinone can be used to investigate the relationship between metabolism in the pulmonary circulation and endothelial cells.
    Duroquinone
  • HY-W073501A
    Glutaconic acid
    		99.57%
    Glutaconic acid is an organic compound with two carboxylic acid groups.
    Glutaconic acid
  • HY-W031126
    7-Hydroxyisoflavone
    		99.75%
    7-Hydroxyisoflavone (compound 3) is a natural isoflavone compound.
    7-Hydroxyisoflavone
  • HY-125938
    Cycloartenyl ferulate
    		99.15%
    Cycloartenyl ferulate (Cycloartenol ferulate; Cycloartenol ferulic acid ester) is a derivative of γ-oryzanol (HY-B2194) with multiple biological activities including antioxidant, anti-inflammatory, and anti-tumor properties. Cycloartenyl ferulate selectively binds to IFNγR1 (binding affinity Kd = 0.5 μM) to activate the canonical JAK1/2-STAT1 signaling pathway. Cycloartenyl ferulate inhibits paraquat (PQ)-triggered apoptosis and ROS in HK2 cells. Cycloartenyl ferulate enhances the activation and cytolytic activity of natural killer (NK) cells by upregulating the expression of NK cell activation receptors (NKG2D, NKp30, NKp44) and the release of cytotoxic molecules and cytokine IFNγ. Cycloartenyl ferulate exerts anti-cancer effects in tumor mice models. Cycloartenyl ferulate can be used for the study of cancer and allergic inflammation intervention.
    Cycloartenyl ferulate
  • HY-165781
    DHA Ceramide
    		98.65%
    DHA Ceramide (C22:6 Ceramide) is an ester product.
    DHA Ceramide
  • HY-W050088
    Isoxepac
    		99.97%
    Isoxepac (HP 549) is an orally active non-steroidal anti-inflammatory agent. Isoxepac can inhibit Carrageenan (HY-125474) paw oedema, adjuvant-induced polyarthritis, and prostaglandin synthesis. Isoxepac (200 mg) has an analgesic effect after meniscectomy with a low incidence of side effects. Isoxepac can be used in the research of inflammatory (rheumatoid arthritis) and pain-related diseases.
    Isoxepac
  • HY-12692
    DO3A tert-Butyl ester
    		98.0%
    DOTA tert-Butyl ester is a cyclic tosamide benzyl derivative.
    DO3A tert-Butyl ester
  • HY-N7055
    Trierucin
    		99.27%
    Trierucin (Trierucoylglycerol) is a triester formed by glycerol and erucic acid, which serves as an occlusive skin conditioning agent and non-aqueous thickener in cosmetics. Long-term feeding of Trierucin to rats induces chronic toxicities such as cardiac lipid deposition and fibrosis.
    Trierucin
  • HY-B0106A
    Etiracetam
    		99.88%
    Etiracetam is a racetam-class nootropic agent. Etiracetam enhances learning and memory in both normal and amnesic rats. Etiracetam can be used in studies related to memory retrieval disorders and amnesic diseases such as Alzheimer's disease.
    Etiracetam
  • HY-153606
    VUBI1 analogue-1
    		98.94%
    VUBI1 analogue-1 (compound 79) is a VUBI1 (HY-111671) analogue. VUBI1 (SOS1 activator 1) is a SOS1 activator with a Kd of 44 nM. VUBI1 analogue-1 can be used to synthesize (4S)-PROTAC SOS1 degrader-1 (HY-144657)[1].
    VUBI1 analogue-1
  • HY-139167
    7-Hydroxywarfarin
    		99.76%
    7-Hydroxywarfarin is a Warfarin analog with anticoagulant activity.
    7-Hydroxywarfarin
  • HY-W015179
    1,2-O-Isopropylidene-alpha-D-xylofuranose
    		99.93%
    1,2-O-Isopropylidene-alpha-D-xylofuranose is a derivative of D-xylose (HY-N0537). 1,2-O-isopropylidene-α-D-xylofuranose can be used in the asymmetric alkylation of Benzaldehyde with Diethylzinc.
    1,2-O-Isopropylidene-alpha-D-xylofuranose
  • HY-101460
    Tz-Thalidomide
    		98.60%
    Tz-Thalidomide is a tetrazine-tagged Thalidomide (HY-14658), an E3 ligase ligand. Tz-Thalidomide self-assembles with TCO-labeled target protein inhibitors, forming a CLIP-TAC (targeted protein degradation chimera) via click chemistry. This chimera recruits the E3 ubiquitin ligase CRBN to the target protein, thereby inducing ubiquitination and subsequent degradation of the target protein. When used in combination with JQ1-TCO (HY-148864), Tz-Thalidomide induces concentration-dependent degradation of BRD4 in cells. When combined with ERK-targeting protein inhibitors, Tz-Thalidomide induces degradation of ERK1/2 in cells. Tz-Thalidomide can be used in cancer-related research.
    Tz-Thalidomide
  • HY-132822
    Ivospemin
    		99.89%
    Ivospemin (SBP-101) is an antineoplastic spermine analog. Ivospemin has shown efficacy in slowing pancreatic and ovarian tumor progression in vitro and in vivo. Ivospemin shows modest induction of polyamine catabolism, but stronger repression of ornithine decarboxylase activity. Ivospemin is promising for research of cancers.
    Ivospemin
  • HY-101495
    18-HEPE
    		99.9%
    18-HEPE (18-Hydroxy-5(Z),8(Z),11(Z),14(Z),16(E)-eicosapentaenoic acid) is an ester product.
    18-HEPE
  • HY-W587907
    5-Formylcytidine
    		99.9%
    5-Formylcytosine is a pyrimidine nitrogen base derived from cytosine.
    5-Formylcytidine
  • HY-15266
    24R-Calcipotriol
    24R-Calcipotriol (PRI 2202; Impurity D of Calcipotriol), an isomer of Calcipotriol (HY-10001), is a synthetic vitamin D analog. 24R-Calcipotriol exhibits synergistic antiproliferative effects with low-dose cytostatics in in vitro. 24R-Calcipotriol produces tumor growth inhibition when combined with Cyclophosphamide (HY-17420) and Cisplatin (HY-17394) in mice models. 24R-Calcipotriol can increase serum calcium levels and reduce blood leukocyte counts. 24R-Calcipotriol can be used for the research of mammary cancer and Lewis lung cancer.
    24R-Calcipotriol
  • HY-W076971
    Ethyl pivaloylacetate
    		98.31%
    Ethyl pivaloylacetate is a β-ketoester. Ethyl pivaloylacetate can be uesd as the substrate to evaluate the activity and stereoselectivity of the ketoreductase tool-box.
    Ethyl pivaloylacetate