2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. OAT

OAT

Organic anion transporter

Organic anion transporters (OATs), a subfamily of the solute carrier 22 (SLC22) transporters, are localized on the physiological barriers of multiple tissues, such as kidney, liver, brain, placenta, retina, and olfactory mucosa. They are the key players for the translocation of various substances into and out of cells, such as signaling molecules, toxins, and a diverse array of important clinical therapeutics, including antivirals, anti-cancer drugs, antibiotics, anti-hypertensives, and anti-inflammatories.

OAT Related Products (34):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-148682R
    18β-Glycyrrhetyl-3-O-sulfate (Standard)
    		Inhibitor
    (Z)-Methyl icos-11-enoate (Standard) is the analytical standard of (Z)-Methyl icos-11-enoate. This product is intended for research and analytical applications. (Z)-Methyl icos-11-enoate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    18β-Glycyrrhetyl-3-O-sulfate (Standard)
  • HY-W740244
    4’-Hydroxy Trazodone
    4’-hydroxy Trazodone is a metabolite of the antidepressant and sedative trazodone. It is an inhibitor of organic anion transporter 3 (OAT3; Ki=16.9 μM) and is selective for OAT3 over OAT1 (Ki=>200 μM).
    4’-Hydroxy Trazodone
  • HY-155485
    Abi-DZ-1
    Abi-DZ-1 is a potential multifunctional theranostic agent via the HIF1α/OATPs pathway. Abi-DZ-1 can be used in the research of tumor-targeted imaging and precision therapy.
    Abi-DZ-1
  • HY-175645
    NLRP3/URAT1-IN-1
    		Inhibitor
    NLRP3/URAT1-IN-1 is an orally active double inhibitor of NLRP3 and URAT1 (IC50 = 3.81 μM). NLRP3/URAT1-IN-1 inhibits IL-1β release in LPS (HY-D1056) and ATP-stimulated mouse bone marrow-derived macrophages (BMDMs), with an IC50 of 2.61 μM. NLRP3/URAT1-IN-1 reduces serum uric acid (SUA) and alleviates liver/kidney damage in mice with acute hyperuricemia (HUA). NLRP3/URAT1-IN-1can be used for the study of gout and hyperuricemia.
    NLRP3/URAT1-IN-1
  • HY-16278A
    Pradigastat sodium
    		Inhibitor
    Pradigastat sodium (LCQ 908 sodium) is a selective and orally effective diacylglyceryl acyltransferase 1 (DGAT1) inhibitor with IC50 at 0.157 µM. Pradigastat is primarily used to study diseases associated with abnormal triglyceride metabolism. Pradigastat has anti-obesity and anti-diabetic effects. Pradigastat inhibited BCRP, OATP1B1, OATP1B3 and OAT3 activities with IC50 of 5 µM, 1.66µM, 3.34µM and 0.973µM, respectively. In addition, Pradigastat has antiviral activity and can inhibit hepatitis C virus replication in vitro.
    Pradigastat sodium
  • HY-138142
    Euphol acetate
    		Inhibitor
    Euphol acetate is a triterpene that can be isolated from Euphorbia broteri. Euphol acetate is an inhibitor of hepatic transport proteins organic anion-transporting polypeptide 1/3 (OATP1B1/3).
    Euphol acetate
  • HY-N12008
    OAT1/3-IN-2
    OAT1/3-IN-2 (compound 8) is a dual inhibitor of OAT1 and OAT3. OAT1/3-IN-2 can reverse the toxicity of Cys-Hg on HEK-OAT1 cells (10 μM) and has a potential protective effect on the kidneys. OAT1/3-IN-2 can be used to study mercury-induced kidney damage.
    OAT1/3-IN-2
  • HY-N12007
    OAT1/3-IN-1
    OAT1/3-IN-1 (compound 7) is a dual inhibitor of OAT1 and OAT3. OAT1/3-IN-1 can reverse the toxicity of Cys-Hg on HEK-OAT1 cells (10 μM) and has a potential protective effect on the kidneys. OAT1/3-IN-1 can be used to study mercury-induced kidney damage.
    OAT1/3-IN-1
  • HY-15592R
    Cabotegravir (Standard)
    		Inhibitor
    Cabotegravir (Standard) is the analytical standard of Cabotegravir. This product is intended for research and analytical applications. Cabotegravir (GSK-1265744) is a orally active and long-acting HIV integrase strand transfer inhibitor and organic anion transporter 1/3 (OAT1/OAT3) inhibitor with IC50 values of 2.5 nM, 0.41 μM and 0.81 μM for HIVADA, OAT3 and OAT1, respectively. Cabotegravir is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral agents (ARVs). Cabotegravir can be used to research AIDS.
    Cabotegravir (Standard)
  • HY-180227
    URAT1-IN-15
    		Inhibitor
    URAT1-IN-15 (Compound 9) is an orally active, selective URAT1 inhibitor with an IC50 of 69.81 nM. URAT1-IN-15 inhibits CYP2C9 (IC50 = 8.39 μM). URAT1-IN-15 shows uricosuric activity. URAT1-IN-15 can be used in the research of hyperuricemia.
    URAT1-IN-15
  • HY-15258S1
    Lesinurad-d4
    		Inhibitor
    Lesinurad-d4 (RDEA594-d4) is deuterium labeled Lesinurad. Lesinurad is a URAT1 and OAT inhibitor, is determined to be a substrate for the kidney transporters OAT1 and OAT3 with Km values of 0.85 and 2 μM, respectively.
    Lesinurad-d<sub>4</sub>
  • HY-16278R
    Pradigastat (Standard)
    		Inhibitor
    Pradigastat (Standard) is the analytical standard of Pradigastat. This product is intended for research and analytical applications. Pradigastat (LCQ-908) is a selective and orally effective diacylglyceryl acyltransferase 1 (DGAT1) inhibitor with IC50 at 0.157 µM. Pradigastat is primarily used to study diseases associated with abnormal triglyceride metabolism. Pradigastat has anti-obesity and anti-diabetic effects. Pradigastat inhibited BCRP, OATP1B1, OATP1B3 and OAT3 activities with IC50 of 5 µM, 1.66µM, 3.34µM and 0.973µM, respectively. In addition, Pradigastat has antiviral activity and can inhibit hepatitis C virus replication in vitro.
    Pradigastat (Standard)
  • HY-B0927R
    Hydrastine (Standard)
    		Inhibitor
    Hydrastine (Standard) is the analytical standard of Hydrastine (HY-B0927). This product is intended for research and analytical applications. Hydrastine ((-)-β-Hydrastine; (1R,9S)-β-Hydrastine) is a selective competitive inhibitor of tyrosine hydroxylase (TH), inhibiting dopamine biosynthesis (IC50=20.7 μM, PC12 cells). Hydrastine also inhibits the organic cation transporter OCT1 (IC50=6.6 μM). Hydrastine may cause neuronal toxicity through mitochondrial dysfunction rather than oxidative stress damage, and can aggravate cell apoptosis when combined with L-DOPA. Hydrastine can be used to study Parkinson's disease-related dopaminergic neuronal damage.
    Hydrastine (Standard)
  • HY-111345A
    Epaminurad hydrochloride
    		Inhibitor
    Epaminurad (UR-1102) hydrochloride is an orally active, potent and selective URAT1 (urate transporter 1) inhibitor, with a Ki of 0.057 μM. Epaminurad hydrochloride quite modestly inhibits OAT1 and OAT3 (organic anion transporter). Epaminurad hydrochloride is a uricosuric agent. Epaminurad hydrochloride can be used for gout and hyperuricemia research.
    Epaminurad hydrochloride