2. GPCR/G Protein
  3. Angiotensin Receptor
  4. Valsartan-d9

Valsartan-d9  (Synonyms: CGP 48933-d9)

Cat. No.: HY-18204S Purity: 99.33%
COA
SDS
Handling Instructions Technical Support

Valsartan-d9 is deuterium labeled valsartan. Valsartan is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research.

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Valsartan-d<sub>9</sub>

Valsartan-d9 화학구조

CAS No. : 1089736-73-1

사이즈 가격 재고 수량
1 mg 견적 받기 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
5 mg   견적 받기  
10 mg   견적 받기  
Synthetic products have potential research and development risk.

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of Valsartan-d9:

Valsartan-d9 Related Antibodies

Top Publications Citing Use of Products

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AT1 Receptor AT2 Receptor

  • Biological Activity

  • Protocol

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

Valsartan-d9 is deuterium labeled valsartan. Valsartan is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research[1].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

IC50 & Target

AT1 Receptor

 

In Vitro

Valsartan is a synthetic non-peptide angiotensin II type 1 receptor antagonist that dilates blood vessels and reduces blood pressure by blocking the action of angiotensin. Valsartan significantly decreases the expression of AT1R in ageing aorta endothelial cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Valsartan-d9 Related Antibodies
분자량

444.57

화학식

C24H20D9N5O3
CAS No.
Unlabeled CAS
Appearance

Solid

Color

White to yellow

SMILES

CC(C)[C@@H](C(O)=O)N(C(C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O)CC(C=C1)=CC=C1C2=CC=CC=C2C3=NN=NN3
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

Ethanol : ≥ 30 mg/mL (67.48 mM)

DMF : ≥ 30 mg/mL (67.48 mM)

DMSO : ≥ 30 mg/mL (67.48 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2494 mL 11.2468 mL 22.4936 mL
5 mM 0.4499 mL 2.2494 mL 4.4987 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서

Purity: 99.33%

SDS (252 KB)

COA (259 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References
Animal Administration
[4]

Rats: Rats are randomly divided into two groups: (i) valsartan-treated group that is given intravenously 3 mg/kg/day valsartan in 0.5 mL normal saline via the vein daily for 1 week; (ii) hydralazine-treated group receiving 0.2 mg/kg/day hydralazine injection in saline; and (iii) control group that receives saline injection in the same way (n=15 for each group)[4].

Mice: Valsartan is dissolved in water containing 0.5% methylcellulose solution. Valsartan (5-40 mg/kg/d) is administered by oral (p.o.) route in a volume of 10 mL/kg body weight using the gavage technique. Potential alteration in blood pressure in response to chronic treatment with valsartan is assessed with a commercial blood pressure analysis systemdesigned. The mice are trained for at least 2 consecutive days to adapt to the apparatus before the study is initiated. To record the blood pressure, the mice are placed on a heated pad (35°C) and measured with a programmable tail-cuff sphygmomanometer in steady state. The average of 10 readings from each mouse is recorded[5].

MCE 는 독립적으로 이러한 방법들의 정확성을 확인하지 않았습니다. 참고용으로만 봐주십시오.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMF / DMSO 1 mM 2.2494 mL 11.2468 mL 22.4936 mL 56.2341 mL
5 mM 0.4499 mL 2.2494 mL 4.4987 mL 11.2468 mL
10 mM 0.2249 mL 1.1247 mL 2.2494 mL 5.6234 mL
15 mM 0.1500 mL 0.7498 mL 1.4996 mL 3.7489 mL
20 mM 0.1125 mL 0.5623 mL 1.1247 mL 2.8117 mL
25 mM 0.0900 mL 0.4499 mL 0.8997 mL 2.2494 mL
30 mM 0.0750 mL 0.3749 mL 0.7498 mL 1.8745 mL
40 mM 0.0562 mL 0.2812 mL 0.5623 mL 1.4059 mL
50 mM 0.0450 mL 0.2249 mL 0.4499 mL 1.1247 mL
60 mM 0.0375 mL 0.1874 mL 0.3749 mL 0.9372 mL
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Valsartan-d9 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Valsartan-d91089736-73-1CGP 48933-d9Angiotensin ReceptorInhibitorinhibitorinhibit

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상품명:
Valsartan-d9
Cat. No.:
HY-18204S
수량:
MCE Japan Authorized Agent:

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SAFETY DATA SHEET (SDS)

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