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XMU-MP-1

81 Cited Publications
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Based on 81 publication(s) in Google Scholar

XMU-MP-1 is a reversible and selective MST1/2 inhibitor with IC50s of 71.1 and 38.1 nM, respectively.

For research use only. We do not sell to patients.

  • Purity: 99.93%
  • CAS No.: 2061980-01-4
  • Formula: C17H16N6O3S2
  • Molecular Weight:416.48
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • XMU-MP-1 Chemical Structure
    XMU-MP-1 Chemical Structure
  • Experimental Validation Results for XMU-MP-1
  • Experimental Validation Results for XMU-MP-1
  • Experimental Validation Results for XMU-MP-1
  • Experimental Validation Results for XMU-MP-1
  • Experimental Validation Results for XMU-MP-1
  • Experimental Validation Results for XMU-MP-1
CAS No.: 2061980-01-4
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • XMU-MP-1 Chemical Structure
    XMU-MP-1 Chemical Structure
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    XMU-MP-1 purchased from MedChemExpress. Usage Cited in: Cell Metab. 2024 Jun 18:S1550-4131(24)00189-X. [Abstract]

    Customer Validation
     Mouse CAFs were treated with HIPPO pathway inhibitor XMU-MP-1 (5 μM, 48h) and tested for HIPPO pathway proteins (YAP, phosphorylation YAP) and NNMT.

  • 1/16

    XMU-MP-1 purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2023 May;43(5):582-612. [Abstract]

    Customer Validation
     Upper panel: WB analysis showing the effects of EGCG (50 µg/mL, 6 h) on expression of the autophagy markers LC3 and p62 in MCF7 and MDA-MB-231 cells with or without the MST1 kinase inhibitor XMU-MP-1 (8 µmol/L; 6 h). Lower panel: WB analysis showing the effects of EGCG (50 µg/mL, 6 h) on expression of the LC3 and p62 in MCF7 and MDA-MB-231 cells after YAP1 knockdown. The results showed that Inhibiting MST1 activity by treatment with XMU‐MP‐1 (8 µmol/L, 6 h) weakened the effects of EGCG on the autophagy markers LC3 II and p62, as did YAP1 knockdown.

  • 1/16

    XMU-MP-1 purchased from MedChemExpress. Usage Cited in: Nature. 2022 Jan;601(7894):600-605. [Abstract]

    Customer Validation
     Left, representative phase-contrast images of trophospheres formed using 3 μM SC144 (top, 96 h) or 2 μM XMU-MP-1 (middle, 96 h), and aggregates of TSCs (bottom) deposited onto stimulated OFELs. Scale bar, 100 μm. Right, attachment efficiency. The results showed that the presence of XMU-MP-1 yielded trophospheres.

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    XMU-MP-1 purchased from MedChemExpress. Usage Cited in: Nature. 2022 Jan;601(7894):600-605. [Abstract]

    Customer Validation
     Immunofluorescence staining for NANOG (Yellow) and CDX2 (Cyan) (left), OCT4 (Yellow) and GATA3 (Cyan) (right) in representative trophospheres formed from a blastoid exposed to XMU-MP-1 (2 µM; 96 h). Scale bar: 50 μm

  • 1/16

    XMU-MP-1 purchased from MedChemExpress. Usage Cited in: Nat Immunol. 2017 Sep;18(9):973-984. [Abstract]

    Customer Validation
     Reduction of Spp1 expression by inhibiting MST1/2. BMMs were cultured on flat- or round-bottom plates (1×105 per well) with or without an Mst1/2 inhibitor (XMU-MP-1; 5 µg/mL).

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    XMU-MP-1 purchased from MedChemExpress. Usage Cited in: Cell Rep. 2017 Dec 19;21(12):3612-3623. [Abstract]

    Customer Validation
     Control and SLMAP mutant HAP1 cells are probed for phosphorylation of MST1/2 (T183/180), YAP (S127 and S397) and MOB1 (T35). Note increased phosphorylation of these proteins in the SLMAP mutant cells, which is completely suppressed by XMU-MP-1 (10μM; 1 h).

  • XMU-MP-1