1. Neuronal Signaling
  2. Amyloid-β
  3. β-Amyloid 1-16

β-Amyloid 1-16 (Synonyms: Amyloid β-Protein (1-16))

Cat. No.: HY-P1466
Handling Instructions

β-Amyloid (1-16) is a β-Amyloid protein fragment involved in metal binding. Beta-amyloid is a peptide that forms amyloid plaques in the brains of Alzheimer's disease (AD) patients.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

β-Amyloid 1-16 Chemical Structure

β-Amyloid 1-16 Chemical Structure

CAS No. : 131580-10-4

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Description

β-Amyloid (1-16) is a β-Amyloid protein fragment involved in metal binding. Beta-amyloid is a peptide that forms amyloid plaques in the brains of Alzheimer's disease (AD) patients.

IC50 & Target

Amyloid-β[1]

In Vivo

β-amyloid (1-16) fragment is considered as valid models to examine the contribution of the key histidine residues (His , His in mouse and His , His , His in human fragments) to the Ab–Cu2+ interaction. Oxidation targets for β-Amyloid (1-16) are the histidine residues coordinated to the metal ions. Copper is bound to Aβ in senile plaque of Alzheimer’s disease with β-Amyloid (1-16) taking part in the coordination of the Cu2+ ions. Cu2+ and Zn2+ are linked with the neurotoxicity of -Amyloid and free radical damage[1]. β-amyloid (1-16) is the minimal amino acidic sequence display a Cu coordination mode which involves three Histidines (His6, His13 and His14). β-amyloid (1-16) is supposed to be involved in metal binding[2]. Human β-amyloid interacts with zinc ions through its metal-binding domain 1-16. The C-tails of the two polypeptide chains of the rat Aβ(1-16) dimer are oriented in opposite directions to each other, which hinders the assembly of rat Aβ dimers into oligomeric aggregates. Thus, the differences in the structure of zinc-binding sites of human and rat β-Amyloid (1-16), their ability to form regular cross-monomer bonds, and the orientation of their hydrophobic C-tails could be responsible for the resistance of rats to Alzheimer's disease[3].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

1955.04

Formula

C₈₄H₁₁₉N₂₇O₂₈

CAS No.

131580-10-4

Sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys

Sequence Shortening

DAEFRHDSGYEVHHQK

Shipping

Room temperature in continental US; may vary elsewhere

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β-Amyloid 1-16
Cat. No.:
HY-P1466
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β-Amyloid 1-16

Cat. No.: HY-P1466