Claudin 18 Antibody (YA5687)

Cat. No.: HY-P85995: Data Sheet User Guide for Antibodies
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Claudin 18 Antibody (YA5687) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Claudin 18.

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사이즈		재고
50 μL		견적 받기
100 μL		견적 받기

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
제품 설명
References

제품 설명

Claudin 18 Antibody (YA5687) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Claudin 18.

Host

Mouse

Clonality

Monoclonal

분자량

Predicted band size: 28 kDa;

Species Reactivity

Human

SwissProt ID

P56856

Gene ID

51208 [NCBI]

Immunogen

Synthesized peptide derived from human Claudin 18 AA range: 150-261

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-400
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:500-5000

Purity	affinity chromatography.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

선적

Shipping with blue ice.

Background

Function：Involved in alveolar fluid homeostasis via regulation of alveolar epithelial tight junction composition and therefore ion transport and solute permeability, potentially via downstream regulation of the actin cytoskeleton organization and beta-2-adrenergic signaling (By similarity). Required for lung alveolarization and maintenance of the paracellular alveolar epithelial barrier (By similarity). Acts to maintain epithelial progenitor cell proliferation and organ size, via regulation of YAP1 localization away from the nucleus and thereby restriction of YAP1 target gene transcription (By similarity). Acts as a negative regulator of RANKL-induced osteoclast differentiation, potentially via relocation of TJP2/ZO-2 away from the nucleus, subsequently involved in bone resorption in response to calcium deficiency (By similarity). Mediates the osteoprotective effects of estrogen, potentially via acting downstream of estrogen signaling independently of RANKL signaling pathways (By similarity); Involved in the maintenance of homeostasis of the alveolar microenvironment via regulation of pH and subsequent T-cell activation in the alveolar space, is therefore indirectly involved in limiting C.neoformans infection; Required for the formation of the gastric paracellular barrier via its role in tight junction formation, thereby involved in the response to gastric acidification

Subcellular Localization：Cell junction, tight junction; Cell membrane; Multi-pass membrane protein; Cell junction, tight junction; Cell junction, tight junction; Lateral cell membrane

Expression：
Tissue_specificity:The expression of this gene is limited to the lungs; the expression of this gene is limited to the gastric mucosa, mainly found in the epithelial cells of the gastric pits and the epithelial cells of the base of the gastric glands, including exocrine and endocrine cells (at the protein level) .

Isoforms & Post-Translational Modification：P56856 has 2 isomers: P56856-1: 27856 Da (predicted); P56856-2: 27720 Da (predicted).

Subunit：Interacts with TJP2/ZO-2 (By similarity). Interacts with TJP1/ZO-1 (By similarity).

Synonyms

Claudin-18

각종 서류

User Guide for Antibodies (1077 KB)

References

[1]. /biology-dictionary/sw480-cell.html [Content Brief]