CLDN18 - claudin 18 Gene

Also Known as SFTA5; SFTPJ

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51208

About CLDN18

Cytogenetic location: 3q22.3 Genomic coordinates (GRCh38): 3:137,998,816-138,033,649 (from NCBI)

This gene has 3 transcripts (splice variants), 234 orthologues and 22 paralogues. Biased expression in stomach (RPKM 335.4) and lung (RPKM 153.8).

Summary

This gene encodes a member of the Claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010]

CLDN18 Products (2)

mRNA Protein Name
NM_001002026.3 NP_001002026.1 claudin-18 isoform 2
NM_016369.4 NP_057453.1 claudin-18 isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19706394 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLDN18 Protein Structure

PMP22_Claudin

PMP22_Claudin: PMP-22/EMP/MP20/Claudin family (7 - 192)

  • 0
  • 100
  • 200
  • 261 a.a.
Protein Preferred Names Protein Names

claudin-18

  • surfactant associated 5

CLDN18 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CLDN18 P56856 EHHADH Homo sapiens Q08426
Validated Y2H
32296183
Intra
CLDN18 P56856 PMP22 Homo sapiens Q01453
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CLDN18 Proteins

Cat. No. Product Name Accession Purity
HY-P70045 Claudin-18/CLDN18.1 Protein, Human (His) P56856-1 (D28-L76) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70701 Claudin-18/CLDN18.2 Protein, Human (His) P56856-2 (D28-L76) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78105 Claudin-18/CLDN18.2 Protein-VLP, Human (Biotinylated, HEK293) P56856-2 (M1-V261) ≥ 95%, as determined by HPLC.
HY-P78368 Claudin-18/CLDN18.2 Protein-VLP, Human (HEK293) P56856-2 (M1-V261) ≥ 95%, as determined by HPLC.
HY-P700403 Claudin-18/CLDN18.2 Protein-VLP, Human (HEK293, His) P56856-2 (M1-V261) Purity analysis by SDS-PAGE is not available for VLP proteins.

CLDN18 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81773 Claudin 18.2 Antibody WB, IHC-P, ICC/IF, FC Human, Mouse, Rat
HY-P85991 Claudin 18.1 Antibody (YA5683) IHC-P, ICC/IF, ELISA Human, Mouse, Rat
HY-P85995 Claudin 18 Antibody (YA5687) IHC-P, ELISA Human

Related Diseases

Diseases Alias
Gastroesophageal Adenocarcinoma

  • Gastric And Esophageal Adenocarcinoma

  • Gastro-Esophageal Adenocarcinoma
Gastroesophageal Junction Adenocarcinoma

  • Adenocarcinoma Of Cardioesophageal Junction

  • Adenocarcinoma Of Gastroesophageal Junction

  • Adenocarcinoma Of The Gastroesophageal Junction
Colitis
Ulcerative Colitis

  • Colitis Gravis

  • Left Sided Ulcerative Colitis

  • Left-Sided Ulcerative Colitis

  • Idiopathic Proctocolitis

  • Inflammatory Bowel Disease, Ulcerative Colitis Type

  • Uc

  • Colitis Ulcerative

  • Colitis, Ulcerative

  • Chronic Left-Sided Ulcerative Colitis

  • Uc - [Ulcerative Colitis]

  • Chronic Ulcerative Enteritis

  • Mucosal Proctocolitis

  • Ulcerative Mucosal Proctocolitis

  • Left Hemicolitis
Bladder Urachal Carcinoma

  • Urachal Cancer

  • Urachal Carcinoma
Urachus Cancer

  • Malignant Tumor Of Urachus
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Diffuse Gastric Cancer

  • Hereditary Diffuse Gastric Adenocarcinoma

  • Hereditary Diffuse Gastric Cancer

  • Signet Cell Adenocarcinoma

  • Signet Ring Cell Carcinoma

  • Signet Ring Cell Gastric Carcinoma

  • Signet Ring Gastric Carcinoma

  • Fdgc

  • Familial Diffuse Cancer Of Stomach

  • Familial Diffuse Gastric Cancer

  • Gastric Cancer, Familial Diffuse

  • Gastric Cancer, Hereditary Diffuse

  • Hdgc

  • Hereditary Diffuse Cancer Of Stomach

  • Diffuse Gastric Cancer Syndrome

  • Cancer, Gastric, Diffuse

  • Carcinoma, Signet Ring Cell

  • Gastric Signet Ring Carcinoma
Signet Ring Cell Adenocarcinoma

  • Signet Ring Cell Carcinoma

  • Carcinoma, Signet Ring Cell

  • Signet Ring Carcinoma

  • Carcinoma Signet Ring Cell
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diffuse Gastric And Lobular Breast Cancer Syndrome

  • Hereditary Diffuse Gastric Cancer

  • HDGC

  • LBC

  • Familial Diffuse Gastric Cancer

  • Fdgc

  • Hereditary Diffuse Gastric Adenocarcinoma

  • Breast Cancer, Lobular

  • Gastric Cancer, Familial Diffuse, And Cleft Lip With Or Without Cleft Palate

  • DGLBC

  • Gastric Cancer, Hereditary Diffuse

  • Gastric Cancer, Familial Diffuse Breast Cancer, Lobular

  • Diffuse Gastric And Lobular Breast Cancer Syndrome With Or Without Cleft Lip And/Or Palate

  • E-Cadherin-Associated Hereditary Gastric Cancer

  • Familial Diffuse Cancer Of Stomach

  • Hereditary Diffuse Cancer Of Stomach

  • Gastric Cancer Familial Diffuse

  • Gastric Cancer Familial Diffuse And Cleft Lip With Or Without Cleft Palate

  • Cancer, Gastric, Hereditary Diffuse
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991681 Emaretamig Inhibitor 97.96% Phase 1

Pre-clinical Phase

Inhibitory Antibodies (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991564 Arcotatug Inhibitor 98% Unkown
HY-P991140 Garetatug Ligand 99.48% Unkown
HY-P991163 Tixentamig Inhibitor ≥99.0% Unkown
HY-P992316 ATG-022 Antibody Modulator / Unkown
HY-P992412 MIL93 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CLDN18 VGNC VGNC:27408
Canis familiaris CLDN18 VGNC VGNC:39314
Rattus norvegicus CLDN18 RGD RGD:1359696
Mus musculus CLDN18 MGD MGI:1929209
Macaca mulatta CLDN18 VGNC VGNC:71248
Felis catus CLDN18 VGNC VGNC:60933
Others CLDN18 NCBI