Emaretamig
Based on 1 Customer Validation
Emaretamig is a humanized IgG1κ monoclonal antibody inhibitor targeting CLDN18 and CD3E. Abdakibart can be used for cancers like gastric and pancreatic cancer research.
For research use only. We do not sell to patients.
- Purity : 97.96%
- CAS No.: 3051701-97-1
- Molecular Weight:175.038 kDa
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Isotype
immunoglobulin (H-gamma1_L-kappa)_(G1(VH-CH1-h)-10merscFvlh-10mer-G1(h-CH2-CH3)_L-kappa)
Species Reactivity
Human
IC50 & Target
[1]|
Claudin-18 |
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
-
half-G1-kappa_VH-CH1-h-(scFv-lambda-heavy)-h-CH2-CH3
Application
ELISA, FACS, Functional assay
Verified Bioactivity
-
Immobilized Claudin-18 Protein, Human (HEK293, HY-P78368) can bind Emaretamig, The ED50 for this effect is 83.60 ng/mL. -
Immobilized CD3 epsilon Protein, Human (HEK293, HY-P70506) can bind Emaretamig. The ED50 for this effect is 190.9 ng/mL.
Chemical Information
-
CAS No. 3051701-97-1
-
Appearance Liquid
-
Molecular Weight 175.038 kDa
-
Color Colorless to light yellow
-
SMILES
N/A
-
Synonyms
ASP-2138
-
Shipping
Shipping with dry ice.
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
-
Data Sheet (255 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)