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Cat. No.: HY-188422

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AZD0901

Name: AZD0901
Brand: MedChemExpress
SKU: HY-188422
Availability: PreOrder

(Synonyms: CMG901)

AZD0901 (CMG901) is an anti-CLDN18.2 antibody-drug conjugate. AZD0901 binds to CLDN18.2, undergoes internalization, disrupts microtubules, and causes direct cytotoxicity and bystander killing. AZD0901 induces ADCC and CDC through its retained IgG1 Fc. AZD0901 can be used in research on gastric or gastroesophageal junction adenocarcinoma and CLDN18.2-positive advanced solid tumors. AZD0901 consists of the antibody Sonesitatug (HY-P991026) and the toxin VcMMAE (HY-15575).

For research use only. We do not sell to patients.

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (280 KB)

AZD0901 Chemical Structure

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Top Publications Citing

Use of MCE Products

One-stop CDMO Service

One-Stop Platform：From Independent R&D to Pilot-Scale Production

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

CLDN18.2

In Vitro

Antibody-drug conjugates (ADCs) are a novel intervention modality consisting of a humanized or human monoclonal antibody conjugated through a chemical linker to a highly cytotoxic small molecule (payload), and hold great potential to achieve a paradigm shift in cancer chemotherapy.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

SMILES

N/A
Synonyms

CMG901
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Katoh M, et al. Claudin 1, 4, 6 and 18 isoform 2 as targets for the treatment of cancer (Review). International journal of molecular medicine. 2024 Nov;54(5):100.

[2]. Dominguez Wiscovitch A, et al. CLDN18.2-Targeted Therapy in Gastrointestinal Cancers. Cancers. 2025 Nov 25;17(23):3764.

[3]. Covert WM, et al. Future Landscape of Anti-Claudin 18.2 Antibodies in Gastric Adenocarcinoma. Antibodies (Basel, Switzerland). 2025 Mar 18;14(1):26.

[4]. Liu J, et al. CLDN18.2-Directed Therapeutics in Gastric and Gastroesophageal Junction Adenocarcinoma: Biomarker Assessment, Expression Dynamics, and Treatment Sequencing. Cancer management and research. 2026;18:611187.

[5]. Wei (Vivian) Wang, et al. Abstract 341: VBC108: a first-in-class CDH17/CLDN18.2 targeted bispecific antibody drug conjugate (ADC) to overcome tumor heterogeneity of gastrointestinal cancers (GC, PADC, CRC, etc.). Cancer Res 15 April 2025; 85 (8_Supplement_1): 341.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

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100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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AZD0901