Ephrin Receptor B4 Antibody (YA2892)(PBS only)

Cat. No.: HY-P83147A: Data Sheet User Guide for Antibodies
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Ephrin Receptor B4 Antibody (YA2892) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ephrin Receptor B4.

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사이즈		재고
50 μL		견적 받기
100 μL		견적 받기

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
제품 설명

제품 설명

Ephrin Receptor B4 Antibody (YA2892) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ephrin Receptor B4.

Host

Rabbit

분자량

Predicted band size: 108 kDa;

Observed band size: 135 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

P54760

Gene ID

2050 [NCBI]

Immunogen

Recombinant protein of human Eph receptor B4/HTK aa17-529.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-1:100

Purity	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

선적

Shipping with blue ice.

Background

Function：Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells

Subcellular Localization：Cell membrane; Single-pass type I membrane protein

Expression：
Tissue_specificity:It is highly expressed in the placenta, but has also been detected in the kidneys, liver, lungs, pancreas, skeletal muscle, and heart. It is expressed in primitive hematopoietic cells and myeloid hematopoietic cells, but not in lymphoid hematopoietic cells. It has also been observed in cell lines derived from the liver, mammary gland, colon, lung, melanocytes, and cervix.

Isoforms & Post-Translational Modification：P54760 has 4 isomers: P54760-1: 108270 Da (predicted); P54760-2: 55975 Da (predicted); P54760-3: 33342 Da (predicted); P54760-4: 45195 Da (predicted).
Phosphorylated; autophosphorylation is stimulated by EFNB2

Subunit：Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer.

Research Field

Cardiovascular

Synonyms

EPHB4; HTK; MYK1; TYRO11; Ephrin type-B receptor 4; Hepatoma transmembrane kinase; Tyrosine-protein kinase TYRO11

각종 서류

User Guide for Antibodies (1077 KB)