EPHB4 - EPH receptor B4 Gene

Also Known as HTK; MYK1; HFASD; CMAVM2; LMPHM7; TYRO11

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2050

About EPHB4

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,802,565-100,827,523 (from NCBI)

This gene has 10 transcripts (splice variants), 171 orthologues, 53 paralogues and is associated with 6 phenotypes. Ubiquitous expression in placenta (RPKM 28.2), endometrium (RPKM 22.9) and 24 other tissues.

Summary

Ephrin receptors and their ligands, the Ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, Ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq, Jul 2008]

EPHB4 Products (1)

mRNA	Protein	Name
NM_004444.5	NP_004435.3	ephrin type-B receptor 4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ephrin receptor activity	IDA IDA: Inferred from direct assay	12734395	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16867992	GOA
enables transmembrane receptor protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	8188704	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell adhesion	IDA IDA: Inferred from direct assay	12734395	GOA
involved in cell migration involved in sprouting angiogenesis	IDA IDA: Inferred from direct assay	12734395	GOA
involved in ephrin receptor signaling pathway	IDA IDA: Inferred from direct assay	12734395	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	8188704	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	8188704	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EPHB4 Protein Structure

Ephrin_lbd

Ephrin_rec_like

fn3

EphA2_TM

Pkinase_Tyr

SAM_1

0
200
400
600
800
987 a.a.

Protein Preferred Names	Protein Names
ephrin type-B receptor 4	ephrin receptor EphB4

EPHB4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EPHB4	P54760	EPO	Homo sapiens	P01588	Anti Bait CoIP	26481148
Intra	EPHB4	P54760	EPO	Homo sapiens	P01588	Solid Phase Assay	26481148
Intra	EPHB4	P54760	EPHA6	Homo sapiens	Q9UF33	Affinity Chrom	35384245
Intra	EPHB4	P54760	EFNB2	Homo sapiens	P52799	BioID	35384245
Intra	EPHB4	P54760	EFNB2	Homo sapiens	P52799	Affinity Chrom	35384245
Intra	EPHB4	P54760	EFNB2	Homo sapiens	P52799	SPR	26481148

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EPHB4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73002	EphB4 Protein, Human (HEK293)	P54760-1/NP_004435.3 (L16-A539)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73003	EphB4 Protein, Human (Active, sf9, His-GST)	P54760-1 (L563-Y987)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P74171	EphB4 Protein, Human (HEK293, Fc)	P54760-1/NP_004435.3 (L16-A539)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P77545	EphB4 Protein, Human (Biotinylated, HEK293, His)	P54760-1/NP_004435.3 (L16-A539)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77646	EphB4 Protein, Human (HEK293, His)	P54760-1/NP_004435.3 (L16-A539)	≥ 95%, as determined by Bis-Tris PAGE.

EPHB4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83147	Ephrin Receptor B4 Antibody (YA2892)	WB, IHC-P	Human, Mouse, Rat
HY-P83147A	Ephrin Receptor B4 Antibody (YA2892)(PBS only)	WB, IHC-P	Human, Mouse, Rat
HY-P84398	Ephrin Receptor B4 Antibody (YA4095)	ICC/IF, ELISA	Human
HY-P84398A	Ephrin Receptor B4 Antibody (YA4095)(PBS only)	ICC/IF, ELISA	Human
HY-P85148	Ephrin Receptor B4 Antibody (YA4840)	WB, IHC-P, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Capillary Malformation-Arteriovenous Malformation 2	CMAVM2 Vein Of Galen Aneurysmal Malformation Vein Of Galen Arteriovenous Malformations Capillary Malformation-Arteriovenous Malformation, Type 2
Lymphatic Malformation 7	LMPHM7 Central Conduction Lymphatic Anomaly Hfasd Hydrops Fetalis, Nonimmune, And/Or Atrial Septal Defect Hydrops Fetalis, Non-Immune, And/Or Atrial Septal Defect Lymphatic Malformation, Type 7 Hydrops Fetalis
Lymphatic Malformation 5	Meige Syndrome Meige Disease Meige Lymphedema Lymphedema Praecox Lymphedema, Late-Onset Late-Onset Lymphedema LMPH2 Meigs Syndrome LMPHM5 Lymphedema, Hereditary, Ii, Formerly Lmph2, Formerly Hereditary Lymphedema Ii Demons-Meigs Syndrome Hereditary Lymphedema Type Ii Lymphedema, Hereditary, 2 Lymphedema, Hereditary, Ii Meige'S Disease
Capillary Malformation-Arteriovenous Malformation 1	Parkes Weber Syndrome Capillary Malformation-Arteriovenous Malformation Capillary Malformation-Arteriovenous Malformation Syndrome CMAVM1 Cmavm Cm-Avm Syndrome Pkws Cm-Avm Parkes-Weber Syndrome Capillary Malformation-Arteriovenous Malformation, Type 1
Arteriovenous Malformation	Arteriovenous Malformations Arteriovenous Hemangioma Cirsoid Aneurysm Racemose Aneurysm Racemose Angioma Racemose Hemangioma Congenital Arteriovenous Malformation
Hereditary Lymphedema I	Lymphedema Hereditary Lymphedema Type I Congenital Primary Lymphedema Lmph1 Milroy Disease Nonne-Milroy Lymphedema Pcl Lymphedema Hereditary Type 1
Hereditary Lymphedema Ia	Lmph1a Lymphedema, Hereditary, Ia Milroy Disease
Lymphatic Malformation 1	Milroy Disease Nonne-Milroy Lymphedema Hereditary Lymphedema Type I Primary Congenital Lymphedema LMPHM1 Pcl Milroy'S Disease Nonne-Milroy Disease Lymphedema, Early-Onset Lymphedema, Hereditary, Type I, Formerly Lymphedema, Hereditary, Ia, Formerly Lmph1a, Formerly Congenital Hereditary Lymphedema Congenital Primary Lymphedema Early Onset Lymphedema Hereditary Lymphedema Hereditary Lymphedema 1 Nonne-Milroy Syndrome Nonne'S Syndrome Congenital Familial Lymphedema Lmph1a Lymphedema, Hereditary, 1a Lymphedema Early-Onset Lymphedema Hereditary Type Ia Lymphatic Malformation, Type 1
Primary Lymphedema	Lymphedema Primary
Tetralogy Of Fallot	TOF Fallot Tetralogy Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle Tetrad Of Fallot Fallot Tetrad Fallot Disease Fallot Complex Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle Interventricular Septal Defect, In Tetralogy Of Fallot Ventricular Septal Defect With Obstructed Right Ventricular Outflow Tof - [Tetralogy Of Fallot] Pulmonary Atresia With Ventricular Septal Defect [Fallot Type] Pulmonary Atresia, Ventricular Septal Defect And Mapcas Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]
Lymphatic Malformation 12	Central Conducting Lymphatic Anomaly LMPHM12 Ccla Lymphatic Malformation-7 Doid:0081030
Immune Hydrops Fetalis	Ihf Immune Hf Immune Fetal Edema Immune Fetal Hydrops
Pyogenic Granuloma	Lobular Capillary Hemangioma Granuloma Pyogenic Granuloma Pyogenicum Granuloma Telangiectaticum Of Skin Pyogenic Granuloma Of Skin Lobular Capillary Haemangioma Of Skin
Generalized Lymphatic Anomaly	Doid:0081031
Brain Stem Astrocytic Neoplasm	Brainstem Astrocytoma Astrocytoma Of Brain Stem
Hereditary Hemorrhagic Telangiectasia	Rendu-Osler-Weber Disease Hht Osler-Weber-Rendu Disease Telangiectasia, Hereditary Hemorrhagic Osler Hemorrhagic Telangiectasia Syndrome Orw Disease Osler Weber Rendu Syndrome Osler-Rendu-Weber Disease Osler-Weber-Rendu Syndrome Rendu-Osler Disease Telangiectasia Hereditary Hemorrhagic Telangiectasia Hemorrhagic, Hereditary Hht - [Hereditary Haemorrhagic Telangiectasia] Osler Haemorrhagic Telangiectasia Syndrome
Weber Syndrome	Midbrain Stroke Syndromes
Liver Carcinoma In Situ	Carcinoma In Situ Of Liver And Biliary System Carcinoma In Situ Of Liver, Gallbladder And Bile Ducts
Kaposi Sarcoma	Kaposi'S Sarcoma Kaposi Sarcoma, Susceptibility To Kaposi'S Sarcoma Of Lung Kaposi'S Sarcoma Of Palate Kaposi'S Sarcoma Of Soft Tissue Kaposi'S Sarcoma-Associated Herpesvirus Multiple Idiopathic Pigmented Hemangiosarcoma Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To African Lymphadenopathic Kaposi'S Sarcoma Anal Kaposi'S Sarcoma Cardiac Kaposi'S Sarcoma Central Nervous System Kaposi'S Sarcoma Conjunctival Kaposi'S Sarcoma Corneal Kaposi'S Sarcoma Cutaneous Kaposi'S Sarcoma Esophageal Kaposi'S Sarcoma Gallbladder Kaposi'S Sarcoma Gastric Kaposi'S Sarcoma Intestinal Kaposi'S Sarcoma Kaposi'S Sarcoma Of Anus Kaposi'S Sarcoma Of Central Nervous System Kaposi'S Sarcoma Of Conjunctiva Kaposi'S Sarcoma Of Cornea Kaposi'S Sarcoma Of Esophagus Kaposi'S Sarcoma Of Gastrointestinal Sites Kaposi'S Sarcoma Of Heart Kaposi'S Sarcoma Of Lymph Nodes Kaposi'S Sarcoma Of Penis Kaposi'S Sarcoma Of Skin Kaposi'S Sarcoma Of Soft Tissues Kaposi'S Sarcoma Of The Cns Kaposi'S Sarcoma Of The Gallbladder Kaposi'S Sarcoma Of The Prostate Kaposi'S Sarcoma, Lung Kaposi'S Sarcoma, Skin Lymph Node Kaposi'S Sarcoma Lymphadenopathic Kaposi'S Sarcoma Palate Kaposi'S Sarcoma Penis Kaposi'S Sarcoma Prostate Kaposi'S Sarcoma Pulmonary Kaposi'S Sarcoma Soft Tissue Kaposi'S Sarcoma Hhv8 Human Herpesvirus 8 Kshv Kaposi Sarcoma Herpesvirus Mediterranean Kaposi Sarcoma Non Aids Related Kaposi Sarcoma Sarcoma, Kaposi Sarcoma, Kaposi, Susceptibility To Non-Aids-Related Kaposi Sarcoma Angiolymphoid Hyperplasia Angiofollicular Ganglionic Hyperplasia Multi-Centric Castleman'S Disease
Microvascular Complications Of Diabetes 1	Proliferative Diabetic Retinopathy Microvascular Complications Of Diabetes, Susceptibility To, 1 MVCD1 Diabetic Nephropathy Non-Proliferative Diabetic Retinopathy Nonproliferative Diabetic Retinopathy Proliferative Retinopathy, Diabetic Proliferative Retinopathy, Diabetic, Susceptibility To Nonproliferative Retinopathy, Diabetic Nonproliferative Retinopathy, Diabetic, Susceptibility To Pdr Diabetic End-Stage Renal Disease Diabetic Neuropathy Diabetic Neuropathies Complications Of Diabetes Mellitus Diabetes Mellitus, Independent Of Type With Proliferative Retinopathy
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Lymphedema-Distichiasis Syndrome	Lymphedema With Distichiasis Lymphedema-Distichiasis Syndrome With Renal Disease And Diabetes Mellitus LPHDST Distichiasis-Lymphedema Syndrome Lymphedema Distichiasis Syndrome Hereditary Lymphedema-Distichiasis Syndrome Lymphedema Distichiasis
Klippel-Trenaunay-Weber Syndrome	Klippel-Trenaunay Syndrome KTS Ktw Syndrome Angioosteohypertrophy Syndrome Angio-Osteohypertrophy Syndrome Klippel Trenaunay Syndrome Klippel-Trénaunay-Weber Syndrome Haemangiectatic Hypertrophy Weber-Klippel-Trenaunay Congenital Dysplastic Angiopathy Klippel-Trenaunay Disease Weber Klippel Trenaunay
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Cardiovascular Organ Benign Neoplasm
Infiltrating Angiolipoma	Angiolipoma, Infiltrating
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos
Hennekam Syndrome	Hennekam Lymphangiectasia Lymphedema Syndrome Hennekam Lymphangiectasia-Lymphedema Syndrome Lymphedema-Lymphangiectasia-Intellectual Disability Syndrome Lymphedem-Lymphangiectasia-Intellectual Disability Syndrome Intestinal Lymphagiectasia Lymphedema Intellectual Deficit Syndrome Lymphangiectasies And Lymphedema Hennekam Type Generalized Lymphatic Dysplasia Intestinal Lymphagiectasia-Lymphedema-Mental Retardation Syndrome
Arteriovenous Malformations Of The Brain	Cerebral Arteriovenous Malformation Intracranial Arteriovenous Malformation Intracranial Hemorrhage In Brain Cerebrovascular Malformations, Susceptibility To Intracranial Arteriovenous Malformations Bavm Cerebral Arteriovenous Malformations Intracranial Hemorrhage In Brain Cerebrovascular Malformations Arteriovenous Malformation Of The Brain, Somatic Intracranial Avm Arteriovenous Malformations Cerebral

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16265	JI-101	Inhibitor	98.99%	Phase 2

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13258A	NVP-BHG712	Inhibitor	99.71%	Unkown
HY-13258	NVP-BHG712 isomer		99.32%	Unkown
HY-136895	AZ12672857	Inhibitor	98.01%	Unkown
HY-179572	STA-013		99.18%	Unkown
HY-RS04436	EPHB4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-10654	EphB4-IN-2	Inhibitor	/	Unkown
HY-15268	PP487	Inhibitor	/	Unkown
HY-155684	SA-PA	Inhibitor	/	Unkown
HY-155685	SA-VA		/	Unkown
HY-16265A	JI-101 hydrochloride	Inhibitor	/	Unkown
HY-185227	EphB4-IN-1	Inhibitor	/	Unkown
HY-N3634	Corylifol C		/	Unkown
HY-171217	TG-100435	Inhibitor	/	Unkown
HY-186005	EPHB4 modulator-1		/	Unkown
HY-RS17762	Ephb4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24229	Ephb4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	EPHB4	MGD	MGI:104757
Canis familiaris	EPHB4	VGNC	VGNC:40413
Rattus norvegicus	EPHB4	RGD	RGD:1583193
Bos taurus	EPHB4	VGNC	VGNC:28540
Felis catus	EPHB4	VGNC	VGNC:61908
Macaca mulatta	EPHB4	VGNC	VGNC:72243
Others	EPHB4	NCBI