2. Gene
  3. EPHA6 - EPH receptor A6 Gene

EPHA6 - EPH receptor A6 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EHK2; EK12; EPA6; EHK-2; HEK12; PRO57066

Gene ID: 285220 | Gene type: protein coding

About EPHA6

Cytogenetic location: 3q11.2 Genomic coordinates (GRCh38): 3:96,814,594-97,761,532 (from NCBI)

This gene has 9 transcripts (splice variants), 307 orthologues and 53 paralogues. Low expression observed in reference dataset.

Summary

Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axon guidance; positive regulation of kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

EPHA6 Products(4)

mRNA Protein Name
NM_001080448.3 NP_001073917.2 ephrin type-A receptor 6 isoform a
NM_001278300.2 NP_001265229.1 ephrin type-A receptor 6 isoform c
NM_001278301.2 NP_001265230.1 ephrin type-A receptor 6 isoform d
NM_173655.4 NP_775926.1 ephrin type-A receptor 6 isoform b

EPHA6 Protein Structure

Ephrin_lbd

Ephrin_lbd: Ephrin receptor ligand binding domain (128 - 301)

fn3

fn3: Fibronectin type III domain (427 - 518)

fn3

fn3: Fibronectin type III domain (549 - 621)

EphA2_TM

EphA2_TM: Ephrin type-A receptor 2 transmembrane domain (643 - 722)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (726 - 807)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (838 - 1024)

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (1059 - 1117)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1130 a.a.
Protein Preferred Names Protein Names

ephrin type-A receptor 6

EPH homology kinase 2

Recombinant EPHA6 Proteins

Cat. No. Product Name Accession Purity
HY-P79191 EphA6 Protein, Human (CHO) AAI56734 (W23-V550) ≥95%

Related Diseases

Diseases Alias
Cefuroxime Allergy

Cephuroxime Allergy

Zinacef Allergy
Oculoauricular Syndrome

OCACS

Schorderet-Munier-Franceschetti Syndrome

Microphthalmia, Microcornea, Anterior Segment Dysgenesis, Cataract, Ocular Coloboma, Retinal Pigment Epithelium Abnormalities, Rod-Cone Dystrophy, And Anomalies Of The External Ear

Oculoauricular Syndrome, Schorderet Type

Oculo-Auricular Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-146375 UniPR505 Antagonist / Unkown
HY-RS04430 EPHA6 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus EPHA6 MGD MGI:108034
Felis catus EPHA6 VGNC VGNC:102693
Bos taurus EPHA6 VGNC VGNC:28536
Canis familiaris EPHA6 VGNC VGNC:58302
Rattus norvegicus EPHA6 RGD RGD:1304614
Macaca mulatta EPHA6 VGNC VGNC:84183
Others EPHA6 NCBI