1. Protein Tyrosine Kinase/RTK
  2. Ephrin Receptor
  3. NVP-BHG712

NVP-BHG712 (Synonyms: BHG712)

Cat. No.: HY-13258A Purity: 99.93%
Handling Instructions

NVP-BHG712 is an oral active EphB4 kinase autophosphorylation inhibitor, with IC50 values of 3.3 nM and 3.0 nM for EphA2 and EphB4, respectively.

For research use only. We do not sell to patients.

NVP-BHG712 Chemical Structure

NVP-BHG712 Chemical Structure

CAS No. : 940310-85-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 100 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 160 In-stock
Estimated Time of Arrival: December 31
50 mg USD 660 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of NVP-BHG712:

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Description

NVP-BHG712 is an oral active EphB4 kinase autophosphorylation inhibitor, with IC50 values of 3.3 nM and 3.0 nM for EphA2 and EphB4, respectively[1][2].

IC50 & Target

IC50: 3.3 nM (EphA2), 3 nM (EphB4)[2].

In Vitro

NVP-BHG712 inhibits VEGF driven vessel formation, while it has only little effects on VEGF receptor (VEGFR) activity. The data suggests a close cross talk between the VEGFR and EphR signaling during vessel formation[2].

In Vivo

NVP-BHG712 (3, 10 and 30 mg/kg, p.o., daily) inhibits VEGF driven tissue growth and angiogenesis[2].

Animal Model: Mice arrying chambers[1].
Dosage: 3, 10 and 30 mg/kg.
Administration: P.O. daily for 4 days.
Result: Significantly inhibited VEGF stimulated tissue formation and vascularization at doses of daily 3 mg/kg. Administration of 10 mg/kg/kg p.o. was sufficient to reverse VEGF enhanced tissue formation and vessel growth.
Molecular Weight

503.48

Formula

C₂₆H₂₀F₃N₇O

CAS No.

940310-85-0

SMILES

CC1=CC=C(C=C1NC2=NC(C3=CC=CN=C3)=NC4=C2C=NN4C)C(NC5=CC=CC(C(F)(F)F)=C5)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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NVP-BHG712
Cat. No.:
HY-13258A
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