Ephrin Receptor B4 Antibody (YA4095)
(Synonyms: HTK; MYK1; TYRO11)Ephrin Receptor B4 Antibody (YA4095) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Ephrin Receptor B4.
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Host:
Mouse
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Isotype:
IgG1
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Application:
ICC/IF, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:10000 |
Product Details
Ephrin Receptor B4 Antibody (YA4095) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Ephrin Receptor B4.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 72 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 108 kDa
Purified recombinant extracellular fragment of human EPHB4 aa Extra(16-539).
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Ephrin Receptor B4 receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein
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Expression
Tissue_specificity:It is highly expressed in the placenta, but has also been detected in the kidneys, liver, lungs, pancreas, skeletal muscle, and heart. It is expressed in primitive hematopoietic cells and myeloid hematopoietic cells, but not in lymphoid hematopoietic cells. It has also been observed in cell lines derived from the liver, mammary gland, colon, lung, melanocytes, and cervix. -
Isoforms & Post-Translational Modification
P54760 has 4 isomers: P54760-1: 108270 Da (predicted); P54760-2: 55975 Da (predicted); P54760-3: 33342 Da (predicted); P54760-4: 45195 Da (predicted).
Phosphorylated; autophosphorylation is stimulated by EFNB2 -
Subunit
Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer.
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SwissProt ID
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Synonyms
HTK; MYK1; TYRO11
Documentation
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