Ephrin Receptor B4 Antibody (YA4095)

Cat. No.: HY-P84398: Data Sheet User Guide for Antibodies
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Ephrin Receptor B4 Antibody (YA4095) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Ephrin Receptor B4.

For research use only. We do not sell to patients.

Size	Stock	Quantity
20 μL	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL	Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

Ephrin Receptor B4 Antibody (YA4095) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Ephrin Receptor B4.

Host

Mouse

Clonality

Monoclonal Antibody

Molecular Weight

Predicted band size: 108 kDa;

Observed band size: 72 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

P54760

Gene ID

2050 [NCBI]

Immunogen

Purified recombinant extracellular fragment of human EPHB4 aa Extra(16-539).

Application &
Dilution Ratio

Application	Dilution Ratio
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:200-1:1000
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS with 0.05% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells

Subcellular Localization：Cell membrane; Single-pass type I membrane protein

Expression：
Tissue_specificity:It is highly expressed in the placenta, but has also been detected in the kidneys, liver, lungs, pancreas, skeletal muscle, and heart. It is expressed in primitive hematopoietic cells and myeloid hematopoietic cells, but not in lymphoid hematopoietic cells. It has also been observed in cell lines derived from the liver, mammary gland, colon, lung, melanocytes, and cervix.

Isoforms & Post-Translational Modification：P54760 has 4 isomers: P54760-1: 108270 Da (predicted); P54760-2: 55975 Da (predicted); P54760-3: 33342 Da (predicted); P54760-4: 45195 Da (predicted).
Phosphorylated; autophosphorylation is stimulated by EFNB2

Subunit：Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer.

Synonyms

HTK; MYK1; TYRO11

Documentation

User Guide for Antibodies (1077 KB)