1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. AZ12672857

AZ12672857 

Cat. No.: HY-136895
Handling Instructions

AZ12672857 is an orally active inhibitor of EphB4 (IC50=1.3 nM) and Src kinases. AZ12672857 shows good inhibition of proliferation of c-Src transfected 3T3 cells (IC50=2 nM) as well as autophosphorylation of EphB4 in transfected CHO-K1 cells (IC50=9 nM).

For research use only. We do not sell to patients.

AZ12672857 Chemical Structure

AZ12672857 Chemical Structure

CAS No. : 945396-55-4

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Description

AZ12672857 is an orally active inhibitor of EphB4 (IC50=1.3 nM) and Src kinases. AZ12672857 shows good inhibition of proliferation of c-Src transfected 3T3 cells (IC50=2 nM) as well as autophosphorylation of EphB4 in transfected CHO-K1 cells (IC50=9 nM)[1].

IC50 & Target[1]

EP4

1.3 nM (IC50)

Src

 

In Vitro

AZ12672857 shows only modest inhibition of CYP P450 (IC50=5 μM against 2C9 and 3A4, >10 μM against 1A4, 2D6 and 2C19). AZ12672857 inhibits p-KDR in HUVEC with an IC50 of 240 nM and inhibits p-PDGFR-βin MG63 cell line with an IC50 of 58 nM[1].

Molecular Weight

486.57

Formula

C₂₆H₃₀N₈O₂

CAS No.

945396-55-4

SMILES

CN(C1=CC=CC2=C1C=NN2)C3=NC(NC4=CC(N5CCOCC5)=CC(N6CCOCC6)=C4)=NC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

AZ12672857AZ 12672857AZ-12672857Prostaglandin Receptorproliferationsurvivalcancer3T3cellsCHO-K1autophosphorylationoralInhibitorinhibitorinhibit

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AZ12672857
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HY-136895
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