Fibrinogen beta chain Antibody (YA4854)

Cat. No.: HY-P85162: Data Sheet User Guide for Antibodies
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Fibrinogen beta chain Antibody (YA4854) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Fibrinogen beta chain.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation
References

Description

Fibrinogen beta chain Antibody (YA4854) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Fibrinogen beta chain.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 56 kDa;

Species Reactivity

Human

SwissProt ID

P02675

Gene ID

2244 [NCBI]

Immunogen

Purified recombinant fragment of human Fibrinogen β (aa30-300) expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:2000
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified

Appearance

Liquid

Formulation

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways

Subcellular Localization：Secreted

Expression：
Tissue_specificity:Protein levels were detected in the plasma.

Subunit：Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain

Synonyms

FGB; Fibrinogen beta chain

Documentation

User Guide for Antibodies (1077 KB)

References

[1]. /biology-dictionary/lovo-cell.html [Content Brief]