FGB - fibrinogen beta chain Gene

Also Known as HEL-S-78p

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2244

About FGB

Cytogenetic location: 4q31.3 Genomic coordinates (GRCh38): 4:154,562,980-154,572,807 (from NCBI)

This gene has 7 transcripts (splice variants), 198 orthologues, 25 paralogues and is associated with 6 phenotypes. Restricted expression toward liver (RPKM 2456.5).

Summary

The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by Thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Fibrinogen serves key roles in hemostasis and antimicrobial host defense. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. [provided by RefSeq, Aug 2020]

FGB Products (9)

mRNA	Protein	Name
NM_001184741.1	NP_001171670.1	fibrinogen beta chain isoform 2 preproprotein
NM_001382759.1	NP_001369688.1	fibrinogen beta chain isoform 3 preproprotein
NM_001382760.1	NP_001369689.1	fibrinogen beta chain isoform 4 preproprotein
NM_001382761.1	NP_001369690.1	fibrinogen beta chain isoform 5 preproprotein
NM_001382762.1	NP_001369691.1	fibrinogen beta chain isoform 6 preproprotein
NM_001382763.1	NP_001369692.1	fibrinogen beta chain isoform 7 preproprotein
NM_001382764.1	NP_001369693.1	fibrinogen beta chain isoform 8 preproprotein
NM_001382765.1	NP_001369694.1	fibrinogen beta chain isoform 9 preproprotein
NM_005141.5	NP_005132.2	fibrinogen beta chain isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to cell adhesion molecule binding	IDA IDA: Inferred from direct assay	9182580	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12706644	GOA
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	19996109	GOA
contributes to signaling receptor binding	IDA IDA: Inferred from direct assay	10903502	GOA
enables structural molecule activity	IDA IDA: Inferred from direct assay	8910396	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in blood coagulation, fibrin clot formation	IDA IDA: Inferred from direct assay	16846481	GOA
involved in cell-matrix adhesion	IDA IDA: Inferred from direct assay	10903502	GOA
involved in fibrinolysis	IDA IDA: Inferred from direct assay	16846481	GOA
involved in induction of bacterial agglutination	IDA IDA: Inferred from direct assay	24367264	GOA
involved in negative regulation of endothelial cell apoptotic process	IDA IDA: Inferred from direct assay	10903502	GOA
involved in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IDA IDA: Inferred from direct assay	10903502	GOA
involved in plasminogen activation	IDA IDA: Inferred from direct assay	16846481	GOA
involved in platelet aggregation	IDA IDA: Inferred from direct assay	6281794	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	10903502	GOA
involved in positive regulation of exocytosis	IDA IDA: Inferred from direct assay	19193866	GOA
involved in positive regulation of heterotypic cell-cell adhesion	IDA IDA: Inferred from direct assay	8100742	GOA
involved in positive regulation of peptide hormone secretion	IDA IDA: Inferred from direct assay	19193866	GOA
involved in positive regulation of protein secretion	IDA IDA: Inferred from direct assay	19193866	GOA
involved in positive regulation of vasoconstriction	IDA IDA: Inferred from direct assay	15739255	GOA
involved in protein polymerization	IDA IDA: Inferred from direct assay	12706644	GOA
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	8910396	GOA
involved in response to calcium ion	IDA IDA: Inferred from direct assay	6777381	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	6777381	GOA
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	6777381	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	6777381	GOA
part of fibrinogen complex	IDA IDA: Inferred from direct assay	6688356	GOA
located in platelet alpha granule	IDA IDA: Inferred from direct assay	6777381	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FGB Protein Structure

Fib_alpha

Fibrinogen_C

0
100
200
300
400
491 a.a.

Protein Preferred Names	Protein Names
fibrinogen beta chain	beta-fibrinogen

FGB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	FGB	P02675	P27958-PRO_0000037566	Hepatitis C virus	P27958-PRO_0000037566	BiFC	20162731

Cross: Cross-species interaction Intra: Intraspecies interaction

FGB Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83924	Fibrinogen beta chain Antibody (YA3621)	WB, ELISA	Human
HY-P83924A	Fibrinogen beta chain Antibody (YA3621)(PBS only)	WB, ELISA	Human
HY-P85162	Fibrinogen beta chain Antibody (YA4854)	WB, ELISA	Human

Related Diseases

Diseases	Alias
Dysfibrinogenemia, Congenital	Dysfibrinogenemia Hypodysfibrinogenemia Familial Dysfibrinogenemia Familial Hypodysfibrinogenemia Hypodysfibrinogenemia, Congenital Dysfibrinogenemia, Familial Congenital Dysfibrinogenemia DYSFIBRIN
Afibrinogenemia, Congenital	Congenital Afibrinogenemia Afibrinogenemia Factor I Deficiency Familial Afibrinogenemia Hypofibrinogenemia, Congenital Fibrinogen Deficiency Afibrinogenemia Congenital CAFBN Congenital Hypofibrinogenemia Hypofibrinogenemia Complement Factor I Deficiency
Hypofibrinogenemia, Familial	Familial Hypofibrinogenemia
Thrombosis	Thrombosis Of Blood Vessel
Pulmonary Embolism	Pulmonary Artery Embolism Pulmonary Embolus Pulmonary Emboli
Budd-Chiari Syndrome	Hepatic Vein Thrombosis Chiari Syndrome BDCHS Membranous Obstruction Of The Inferior Vena Cava Budd-Chiari Syndrome, Somatic Movc Budd-Chiari Syndrome, Susceptibility To, Somatic Budd-Chiari Syndrome, Susceptibility To Membranous Obstruction Of Inferior Vena Cava Hepatic Vein Block Obstruction Of Hepatic Veins Hepatic Vein Obstruction Hepatic Venous Block
Thrombophilia	Hypercoagulability State
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Lateral Medullary Syndrome	Posterior Inferior Cerebellar Artery Syndrome Wallenberg Syndrome Vertebral Artery Syndrome Wallenberg'S Syndrome Pica Syndrome
Familial Hypercholesterolemia	Hyperlipoproteinemia Type Iia Familial Hyperbetalipoproteinaemia Familial Hypercholesteremia Fredrickson Type Iia Hyperlipoproteinemia Fredrickson Type Iia Lipidaemia Hyperbetalipoproteinemia Type Ii Hyperlipidemia Familial Hypercholesterolæmia Familial Hypercholesterolaemia Fh Hypercholesterolemia Familial Hyperlipoproteinemia Type Ii Hypercholesterolemia, Familial
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Vascular Anomaly Spinal Cord Vascular Diseases Vascular Tissue Disease
Alopecia-Mental Retardation Syndrome 1	APMR1 Alopecia-Intellectual Disability Syndrome 1 Amr Syndrome Alopecia-Intellectual Disability Syndrome Amr Syndrome 1 Alopecia With Severe Intellectual Deficit Apmr Alopecia Intellectual Disbility Syndrome 1 Perniola-Krajewska-Carnevale Syndrome Alopecia - Intellectual Disability Syndrome Alopecia With Mental Retardation Syndrome 1 Perniola Krajewska Carnevale Syndrome
Cerebral Palsy	Infantile Cerebral Palsy Mixed Cerebral Palsy Palsy Cerebral Palsy, Cerebral Cerebral Palsy, Mixed
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS19861	Fgb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04879	FGB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26361	Fgb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FGB	MGD	MGI:99501
Canis familiaris	FGB	VGNC	VGNC:54207
Rattus norvegicus	FGB	RGD	RGD:2604
Felis catus	FGB	VGNC	VGNC:62238
Macaca mulatta	FGB	VGNC	VGNC:72641
Bos taurus	FGB	VGNC	VGNC:28963
Others	FGB	NCBI