GPCR RDC1/CXCR-7 Antibody (YA2957)(PBS only)

Cat. No.: HY-P83212A: Ficha de datos User Guide for Antibodies
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GPCR RDC1/CXCR-7 Antibody (YA2957) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GPCR RDC1/CXCR-7.

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Tamaño		Stock
50 μL		Obtener un presupuesto
100 μL		Obtener un presupuesto

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Descripciòn

Descripciòn

GPCR RDC1/CXCR-7 Antibody (YA2957) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GPCR RDC1/CXCR-7.

Host

Rabbit

Peso molecular

Predicted band size: 41 kDa;

Observed band size: 41 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

P25106

Gene ID

57007 [NCBI]

Immunogen

A synthetic peptide of human GPCR RDC1

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000

Pureza	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Envío

Shipping with blue ice.

Background

Function：Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1 (PubMed:16107333, PubMed:19255243, PubMed:19380869, PubMed:20161793, PubMed:22300987). Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway (PubMed:16940167, PubMed:18653785, PubMed:20018651). Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness (PubMed:16940167, PubMed:18653785). In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival (PubMed:16940167, PubMed:20388803). Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration (PubMed:17804806, PubMed:18653785, PubMed:19641136, PubMed:20887389). Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12 (PubMed:18653785). Required for heart valve development (PubMed:17804806). Regulates axon guidance in the oculomotor system through the regulation of CXCL12 levels (PubMed:31211835); (Microbial infection) Acts as a coreceptor with CXCR4 for a restricted number of HIV isolates

Subcellular Localization：Cell membrane; Multi-pass membrane protein; Early endosome; Recycling endosome

Expression：
Tissue_specificity:It is expressed in monocytes, basophils, B cells, umbilical vein endothelial cells (HUVECs) , and B lymphoblasts. It is expressed at lower levels in CD4+ T lymphocytes and natural killer cells. In brain tissue, it can be detected in endothelial cells and capillaries, as well as in mature neurons of the frontal cortex and hippocampus. It is expressed during renal tubule formation in the kidneys. It is highly expressed in astrocytoma endothelial cells, microglia, and glioma cells. It is expressed at low levels in normal CD34+ progenitor cells but at high levels in several myeloid malignant cell lines. It is expressed in breast cancer but not in normal breast tissue (protein level) .

Induction:Up-regulated during cell differentiation in glioma cells

Subunit：Homodimer. Can form heterodimers with CXCR4; heterodimerization may regulate CXCR4 signaling activity. Interacts with ARRB1 and ARRB2

Research Field

Signal Transduction

Synonyms

RDC1; CXCR7; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159

Documentación

User Guide for Antibodies (1077 KB)