ACKR3 - atypical chemokine receptor 3 Gene

Also Known as RDC1; CXCR7; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57007

About ACKR3

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:236,537,122-236,582,354 (from NCBI)

This gene has 2 transcripts (splice variants), 252 orthologues, 23 paralogues and is associated with 53 phenotypes. Broad expression in placenta (RPKM 50.1), urinary bladder (RPKM 36.9) and 22 other tissues.

Summary

This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an Orphan Receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. [provided by RefSeq, Jul 2008]

ACKR3 Products (6)

mRNA Protein Name
XM_005246098.4 XP_005246155.1 atypical chemokine receptor 3 isoform X1
XM_047445136.1 XP_047301092.1 atypical chemokine receptor 3 isoform X1
NM_001047841.1
NM_020311.3 NP_064707.1 atypical chemokine receptor 3
XM_005246097.4 XP_005246154.1 atypical chemokine receptor 3 isoform X1
XM_047445135.1 XP_047301091.1 atypical chemokine receptor 3 isoform X1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables C-X-C chemokine binding IMP
IMP: Inferred from mutant phenotype
22300987 GOA
enables C-X-C chemokine receptor activity IMP
IMP: Inferred from mutant phenotype
20388803 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19380869 GOA
enables scavenger receptor activity IMP
IMP: Inferred from mutant phenotype
22300987 GOA
Biological Process GO Annotation Evidence Références Source
involved in chemokine-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
20388803 GOA
involved in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: Inferred from mutant phenotype
20388803 GOA
involved in oculomotor nerve development IMP
IMP: Inferred from mutant phenotype
31211835 GOA
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
22300987 GOA
involved in receptor internalization IMP
IMP: Inferred from mutant phenotype
22300987 GOA
Cellular Component GO Annotation Evidence Références Source
located in cell surface IDA
IDA: Inferred from direct assay
22457824 GOA
located in clathrin-coated pit IDA
IDA: Inferred from direct assay
22457824 GOA
located in endosome IDA
IDA: Inferred from direct assay
22300987 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
22300987 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACKR3 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (62 - 315)

  • 0
  • 100
  • 200
  • 300
  • 362 a.a.
Protein Preferred Names Protein Names

atypical chemokine receptor 3

  • C-X-C chemokine receptor type 7

  • G protein-coupled receptor

  • G-protein coupled receptor 159

  • G-protein coupled receptor RDC1 homolog

  • chemokine (C-X-C motif) receptor 7

  • chemokine orphan receptor 1

ACKR3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
ACKR3 P25106 CXCR4 Homo sapiens P61073
PLA
28862946
Intra
ACKR3 P25106 CXCR4 Homo sapiens P61073
Confocal
21730065
Intra
ACKR3 P25106 CXCR4 Homo sapiens P61073
BRET
19380869
Intra
ACKR3 P25106 CXCR4 Homo sapiens P61073
PLA
29386406
Intra
ACKR3 P25106 CXCR4 Homo sapiens P61073
PLA
27331810
Intra
ACKR3 P25106 AVPR1A Homo sapiens P37288
PLA
29386406
Intra
ACKR3 P25106 AVPR1A Homo sapiens P37288
BRET
29386406
Intra
ACKR3 P25106 AVPR1A Homo sapiens P37288
Anti Tag CoIP
29386406
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ACKR3 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P700537 ACKR3 Protein, Human (His-SUMO) P25106 (M1-K40) ≥ 90%, as determined by reducing SDS-PAGE.

ACKR3 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P83212 GPCR RDC1/CXCR-7 Antibody (YA2957) WB Human, Mouse, Rat
HY-P83212A GPCR RDC1/CXCR-7 Antibody (YA2957)(PBS only) WB Human, Mouse, Rat
HY-P84210 GPCR RDC1/CXCR-7 Antibody (YA3907) IHC-P, ICC/IF, FC, ELISA Human
HY-P84210A GPCR RDC1/CXCR-7 Antibody (YA3907)(PBS only) IHC-P, ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Oculomotor-Abducens Synkinesis

  • OCABSN
Whim Syndrome 1

  • Whim Syndrome

  • Whims

  • Warts, Hypogammaglobulinemia, Infections, And Myelokathexis

  • WHIMS1

  • Warts-Hypogammaglobulinemia-Infections-Myelokathexis Syndrome

  • Warts, Hypogammaglobulinemia, Infections, And Myelokathexis Syndrome 1

  • Myelokathexis, Isolated

  • Wilm

  • Warts-Infections-Leukopenia-Myelokatexis Syndrome

  • Warts, Hypogammaglobulinemia, Infections And Myelokathexis Syndrome 1
Glioma
Ptosis

  • Blepharoptosis

  • Drooping Eyelid

  • Droopy Eyelid

  • Ptosis Of Eyelid

  • Paralysis Of Levator Palpebrae Superioris
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-P10333A LIH383 TFA Agonist 99.83% Unkown
HY-123813 CCX-777 Agonist 98.47% Unkown
HY-123813A CCX-777 formic Agonist 98.01% Unkown
HY-RS00162 ACKR3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-159582 ACKR3 agonist 1 Agonist / Unkown
HY-161414 trans-VUF25471 Agonist / Unkown
HY-179035 TBS6b Degrader / Unkown
HY-182533 LN5972 Agonist / Unkown
HY-184086 Cyclazosin / Unkown
HY-D2201 Fluorescent ACKR3 antagonist 1 / Unkown
HY-P10333 LIH383 Agonist / Unkown
HY-RS00163 Ackr3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00164 Ackr3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174787 Human ACKR3 mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ACKR3 MGD MGI:109562
Canis familiaris ACKR3 VGNC VGNC:37509
Rattus norvegicus ACKR3 RGD RGD:620601
Bos taurus ACKR3 VGNC VGNC:25541
Felis catus ACKR3 VGNC VGNC:59511
Macaca mulatta ACKR3 VGNC VGNC:69513
Others ACKR3 NCBI