AVPR1A - arginine vasopressin receptor 1A Gene

Homo sapiens

Also known as V1aR; AVPR1; AVPR V1a

Gene ID: 552 | Gene type: protein coding

About AVPR1A

Cytogenetic location: 12q14.2 Genomic coordinates (GRCh38): 12:63,142,759-63,151,201 (from NCBI)

This gene has 2 transcripts (splice variants), 264 orthologues and 16 paralogues. Biased expression in adrenal (RPKM 29.7), endometrium (RPKM 8.7) and 7 other tissues.

Summary

The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis. [provided by RefSeq, Jul 2008]

AVPR1A Products(1)

mRNA	Protein	Name
NM_000706.5	NP_000697.1	vasopressin V1a receptor

AVPR1A Protein Structure

7tm_1

DUF1856

0
100
200
300
418 a.a.

Protein Preferred Names

Protein Names

vasopressin V1a receptor

SCCL vasopressin subtype 1a receptor	V1-vascular vasopressin receptor AVPR1A
V1a vasopressin receptor	antidiuretic hormone receptor 1A
vascular/hepatic-type arginine vasopressin receptor

Related Diseases

Diseases

Alias

Personality Disorder

Personality Disorders	Character Disorder
Personality	Specific Personality Disorders
Enduring Personality Change After Psychiatric Illness

Diabetes Insipidus

Episodic Pain Syndrome, Familial, 1

FEPS1	Familial Episodic Pain Syndrome With Predominantly Upper Body Involvement
Familial Episodic Pain Syndrome 1

Voyeurism

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Asperger Syndrome

Asperger Disorder

Panic Disorder

Panic Anxiety Syndrome	Panic
Panic Disorder 1	Episodic Paroxysmal Anxiety Disorder

X-Linked Nephrogenic Diabetes Insipidus

Nephrogenic Diabetes Insipidus Type 1

Doid:0081060

Nephrogenic Diabetes Insipidus

Vasopressin-Resistant Diabetes Insipidus	Diabetes Insipidus, Nephrogenic
Diabetes Insipidus Nephrogenic	Congenital Nephrogenic Diabetes Insipidus
Adh Resistant Diabetes Insipidus	Diabetes Insipidus Nephrogenic X-Linked
Diabetes Insipidus Nephrogenic Type 1	Adh-Resistant Diabetes Insipidus
Diabetes Insipidus Renalis	Ndi
Renal Diabetes Insipidus	Familial Nephrogenic Diabetes
Antidiuretic-Hormone-Resistant Diabetes Insipidus	Adiuretin-Resistant Diabetes Insipidus
Ndi - [Nephrogenic Diabetes Insipidus]	Diabetes Tenuifluus
Adh - [Antidiuretic-Hormone] Resistant Diabetes Insipidus	Hereditary Nephrogenic Diabetes Insipidus
Familial Nephrogenic Diabetes Insipidus	Primary Nephrogenic Diabetes Insipidus

Borderline Personality Disorder

Diabetes Insipidus, Neurohypophyseal

Neurohypophyseal Diabetes Insipidus	Central Diabetes Insipidus
Cdi	Pituitary Diabetes Insipidus
Vasopressin Defective Diabetes Insipidus	Vasopressin Deficiency
Diabetes Insipidus, Neurogenic	Diabetes Insipidus, Primary Central
Diabetes Insipidus, Cranial Type	Diabetes Insipidus Secondary To Vasopressin Deficiency
Diabetes Insipidus, Central	Diabetes Insipidus, Pituitary
NDI	Diabetes Insipidus Cranial Type
Neurogenic Diabetes Insipidus	Primary Central Diabetes Insipidus

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Amusia

Receptive Amusia

Nephrogenic Syndrome Of Inappropriate Antidiuresis

NSIAD

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Pervasive Developmental Disorder

Pervasive Development Disorder	Pervasive Developmental Disorders
Pervasive Child Development Disorders	Autistic Behavior
Autism Spectrum Disorders

Hepatorenal Syndrome

Hepato-Renal Syndrome	Hepatorenal Failure
Hrf - [Hepatorenal Failure]	Hepatorenal Degeneration
Hepatic Renal Syndrome	Hepatic Renal Failure
Renal Hepatic Failure	Urohepatic Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0049A	Argipressin diacetate		/	Unkown

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P4990	Pro8-Oxytocin	Activator	/	Unkown
HY-P4990A	Pro8-Oxytocin TFA	Activator	/	Unkown
HY-RS01281	AVPR1A Human Pre-designed siRNA Set A		/	Unkown
HY-RS01282	Avpr1a Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS01283	Avpr1a Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	AVPR1A	MGD	MGI:1859216
Canis familiaris	AVPR1A	VGNC	VGNC:38318
Rattus norvegicus	AVPR1A	RGD	RGD:2185
Felis catus	AVPR1A	VGNC	VGNC:68838
Macaca mulatta	AVPR1A	VGNC	VGNC:70197
Bos taurus	AVPR1A	VGNC	VGNC:26358

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