2. Apoptosis GPCR/G Protein
  3. Apoptosis Vasopressin Receptor
  4. Argipressin diacetate

Argipressin diacetate  (Synonyms: Arg8-vasopressin diacetate; AVP diacetate; ADH)

Cat. No.: HY-P0049A
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Argipressin (diacetate) (AVP (diacetate), also known as antidiuretic hormone (ADH)) is a 9 amino acid neuropeptide secreted by the posterior pituitary. Argipressin (diacetate) (AVP (diacetate)) can regulate the biological effects of fluid balance, osmolality and cardiovascular through three separate G-protein coupled receptors (GPCRs), namely Avpr1a (V1a), Avpr1b (V1b) and Avpr2 (V2). Argipressin (diacetate) (AVP (diacetate)) also have potentially important effects on centrally regulated metabolic processes.

For research use only. We do not sell to patients.

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CAS No. : 75499-44-4

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Other In-stock Forms of Argipressin diacetate:

Other Forms of Argipressin diacetate:

Argipressin diacetate Related Antibodies

Top Publications Citing Use of Products

    Argipressin diacetate purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Dec:206:115265.  [Abstract]

    H9c2 cell viability measured 48 h after exposure to different arginine Argipressin (AVP) concentrations (0–500 µM).

    Argipressin diacetate purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Dec:206:115265.  [Abstract]

    Representative images of Argipressin (AVP) (300 µM) TUNEL staining.

    Argipressin diacetate purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Dec:206:115265.  [Abstract]

    Argipressin (AVP) (300 µM). Representative Western blot images.

    Argipressin diacetate purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Dec:206:115265.  [Abstract]

    Argipressin (AVP) (300 µM). Representative fluorescence images of DCFH-DA loading and quantitative analysis of reactive oxygen species (ROS) levels in H9c2 cells of the Con and AVP groups.

    Argipressin diacetate purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Dec:206:115265.  [Abstract]

    Argipressin (AVP) (300 µM). Representative immunofluorescence images of nuclear factor E2-associated factor 2 (Nrf2) expression in two groups of cells.

    Argipressin diacetate purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2022 Oct 15:933:175262.

    Vasopressin (AVP) (10 μM; 48 h) increased neonatal primary rat cardiomyocyte surface areas.

    Argipressin diacetate purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2022 Oct 15:933:175262.

    Vasopressin (AVP) (10 μM; 48 h) increased mRNA expression levels of cardiomyocyte hypertrophy markers BNP, TRPC6, and β-MHC in cardiomyocytes.

    Argipressin diacetate purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2022 Oct 15:933:175262.

    Vasopressin (AVP) (10 μM; 48 h) markedly increased malondialdehyde (MDA) levels, an indicator of mitochondrial oxidative stress levels, in cardiomyocytes.

    Argipressin diacetate purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2022 Oct 15:933:175262.

    Representative fluorescent JC-1 images and quantification of mitochondrial membrane potential (MMP) levels, in terms of the ratio of green (representing JC-1 monomers, and therefore depolarization and lowered MMP) to red (representing JC-1 aggregates) JC-1 fluorescence, were obtained in Vasopressin (AVP) (10 μM; 48 h)-treated cardiomyocytes.

    Argipressin diacetate purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2022 Oct 15:933:175262.

    Vasopressin (AVP) (10 μM; 48 h) significantly decreased p-Mst1, the active phosphorylated form of Mst1, and nuclear Nrf2 protein levels in cardiomyocytes.

    View All Vasopressin Receptor Isoform Specific Products:

    View All Isoforms
    V1a Receptor  V1b Receptor  V2 Receptor 

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Argipressin (diacetate) (AVP (diacetate), also known as antidiuretic hormone (ADH)) is a 9 amino acid neuropeptide secreted by the posterior pituitary. Argipressin (diacetate) (AVP (diacetate)) can regulate the biological effects of fluid balance, osmolality and cardiovascular through three separate G-protein coupled receptors (GPCRs), namely Avpr1a (V1a), Avpr1b (V1b) and Avpr2 (V2). Argipressin (diacetate) (AVP (diacetate)) also have potentially important effects on centrally regulated metabolic processes[1].

    In Vitro

    Argipressin (diacetate) (AVP (diacetate)) induces proliferation and prevented cytokine-induced apoptosis in rodent and human beta-cells[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Argipressin diacetate Related Antibodies

    Cell Proliferation Assay[1]

    Cell Line: clonal BRIN BD11 and 1.1B4 cells
    Concentration: 10-6 M
    Incubation Time: 2 h
    Result: Increased proliferation of rodent and human beta-cells.

    Apoptosis Analysis[1]

    Cell Line: clonal BRIN BD11 and 1.1B4 cells
    Concentration: 10-6 M
    Incubation Time: 2 h
    Result: Protected against cytokine-induced beta-cell apoptosis.
    In Vivo

    Argipressin (diacetate) (AVP (diacetate)) (25 nmol/kg bw; intraperitoneal injection; once) significantly reduces overall AUC glucose values, but not increases insulin levels in mice[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: NIH Swiss mice (adult; male; 12-14weeks) [1]
    Dosage: 25 nmol/kg bw
    Administration: AVP (25 nmol/kg bw; intraperitoneal injection; once)
    Result: Reduced (P<0.001) overall AUC glucose values，but not increased insulin levels in mice.
    Clinical Trial
    Molecular Weight

    1204.34

    Formula

    C50H73N15O16S2
    CAS No.
    Sequence

    Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bridge: Cys1-Cys6)
    Sequence Shortening

    CYFQNCPRG-NH2 (Disulfide bridge: Cys1-Cys6)
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Argipressin diacetate Related Classifications

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    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Argipressin diacetate75499-44-4Arg8-vasopressin diacetate AVP diacetate ADHApoptosisVasopressin ReceptorArginine vasopressinAVPADHfluid balanceosmolalityInhibitorinhibitorinhibit

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