Cat. No.: HY-P0049A

Argipressin diacetate

(Synonyms: Arg8-vasopressin diacetate; AVP diacetate; ADH)

17 Cited Publications

Customer Review

Based on 17 publication(s) in Google Scholar

Argipressin (diacetate) (AVP (diacetate), also known as antidiuretic hormone (ADH)) is a 9 amino acid neuropeptide secreted by the posterior pituitary. Argipressin (diacetate) (AVP (diacetate)) can regulate the biological effects of fluid balance, osmolality and cardiovascular through three separate G-protein coupled receptors (GPCRs), namely Avpr1a (V1a), Avpr1b (V1b) and Avpr2 (V2). Argipressin (diacetate) (AVP (diacetate)) also have potentially important effects on centrally regulated metabolic processes.

For research use only. We do not sell to patients.

CAS No.: 75499-44-4
Formula: C₅₀H₇₃N₁₅O₁₆S₂
Molecular Weight:1204.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Argipressin diacetate Chemical Structure

CAS No.: 75499-44-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (17)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Vasopressin Receptor Isoforms :

In Vitro

Argipressin (diacetate) (AVP (diacetate)) induces proliferation and prevented cytokine-induced apoptosis in rodent and human beta-cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

clonal BRIN BD11 and 1.1B4 cells
Concentration:

10^-6 M
Incubation Time:

2 h
Result:

Increased proliferation of rodent and human beta-cells.

Apoptosis Analysis^[1]

Cell Line:

clonal BRIN BD11 and 1.1B4 cells
Concentration:

10^-6 M
Incubation Time:

2 h
Result:

Protected against cytokine-induced beta-cell apoptosis.

In Vivo

Argipressin (diacetate) (AVP (diacetate)) (25 nmol/kg bw; intraperitoneal injection; once) significantly reduces overall AUC glucose values, but not increases insulin levels in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NIH Swiss mice (adult; male; 12-14weeks) ^[1]
Dosage:

25 nmol/kg bw
Administration:

AVP (25 nmol/kg bw; intraperitoneal injection; once)
Result:

Reduced (P<0.001) overall AUC glucose values，but not increased insulin levels in mice.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 75499-44-4
Molecular Weight 1204.34
Formula C₅₀H₇₃N₁₅O₁₆S₂
Synonyms

Arg8-vasopressin diacetate; AVP diacetate; ADH
Sequence

Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bridge: Cys1-Cys6)
Sequence Shortening

CYFQNCPRG-NH2 (Disulfide bridge: Cys1-Cys6)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (17)

All Cell Proliferation/Viability AssayCell Imaging/StainingRT-PCRWBBio/Physico-chemical AssayIF

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Journal Impact Factor

Nat Commun

Structural insights into antagonist recognition by the vasopressin V2 receptor. [Abstract]

2025 Nov 4;16(1):9734. PMID: 41188237
Nat Commun

Oxytocinergic input from the paraventricular nucleus to the nucleus accumbens core modulates methamphetamine-conditioned place preference. [Abstract]

2025 May 23;16(1):4808. PMID: 40410135
Nat Chem Biol

Photo-cross-linking-assisted deorphanization deciphers GPR50-L-LEN pairing in metabolism. [Abstract]

2026 Jan 6. PMID: 41495223
J Ethnopharmacol

Wuling San regulates AVPR2-cAMP-PKA-CREB pathway to delay cellular senescence and ameliorate acute kidney injury. [Abstract]

2025 May 12:347:119679. PMID: 40216046
Biochem Pharmacol

Melatonin alleviates arginine vasopressin-induced cardiomyocyte apoptosis via increasing Mst1-Nrf2 pathway activity to reduce oxidative stress. [Abstract]

2022 Dec:206:115265. PMID: 36183803

Argipressin diacetate purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Dec:206:115265. [Abstract]

H9c2 cell viability measured 48 h after exposure to different arginine Argipressin (AVP) concentrations (0–500 µM).

Argipressin diacetate purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Dec:206:115265. [Abstract]

Representative images of Argipressin (AVP) (300 µM) TUNEL staining.

Argipressin diacetate purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Dec:206:115265. [Abstract]

Argipressin (AVP) (300 µM). Representative Western blot images.

Argipressin diacetate purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Dec:206:115265. [Abstract]

Argipressin (AVP) (300 µM). Representative fluorescence images of DCFH-DA loading and quantitative analysis of reactive oxygen species (ROS) levels in H9c2 cells of the Con and AVP groups.

Argipressin diacetate purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Dec:206:115265. [Abstract]

Argipressin (AVP) (300 µM). Representative immunofluorescence images of nuclear factor E2-associated factor 2 (Nrf2) expression in two groups of cells.
Eur J Pharmacol

Melatonin activates the Mst1-Nrf2 signaling to alleviate cardiac hypertrophy in pulmonary arterial hypertension. [Abstract]

2022 Oct 15:933:175262. PMID: 36100129

Argipressin diacetate purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2022 Oct 15:933:175262. [Abstract]

Vasopressin (AVP) (10 μM; 48 h) increased neonatal primary rat cardiomyocyte surface areas.

Argipressin diacetate purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2022 Oct 15:933:175262. [Abstract]

Vasopressin (AVP) (10 μM; 48 h) increased mRNA expression levels of cardiomyocyte hypertrophy markers BNP, TRPC6, and β-MHC in cardiomyocytes.

Argipressin diacetate purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2022 Oct 15:933:175262. [Abstract]

Vasopressin (AVP) (10 μM; 48 h) markedly increased malondialdehyde (MDA) levels, an indicator of mitochondrial oxidative stress levels, in cardiomyocytes.

Argipressin diacetate purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2022 Oct 15:933:175262. [Abstract]

Representative fluorescent JC-1 images and quantification of mitochondrial membrane potential (MMP) levels, in terms of the ratio of green (representing JC-1 monomers, and therefore depolarization and lowered MMP) to red (representing JC-1 aggregates) JC-1 fluorescence, were obtained in Vasopressin (AVP) (10 μM; 48 h)-treated cardiomyocytes.

Argipressin diacetate purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2022 Oct 15:933:175262. [Abstract]

Vasopressin (AVP) (10 μM; 48 h) significantly decreased p-Mst1, the active phosphorylated form of Mst1, and nuclear Nrf2 protein levels in cardiomyocytes.
Front Pharmacol

Intradermal Injection of Oxytocin Aggravates Chloroquine-Induced Itch Responses via Activating the Vasopressin-1a Receptor/Nitric Oxide Pathway in Mice. [Abstract]

2019 Nov 15:10:1380. PMID: 31824317
J Cell Mol Med

Effects of arginine vasopressin on the transcriptome of prefrontal cortex in autistic rat model. [Abstract]

2022 Nov;26(21):5493-5505. PMID: 36239083
Front Neurosci

The Changes of Amygdala Transcriptome in Autism Rat Model After Arginine Vasopressin Treatment. [Abstract]

2022 Mar 25;16:838942. PMID: 35401102
Endocrinology

Aspirin Suppresses Hepatic Glucagon Signaling Through Decreasing Production of Thromboxane A2. [Abstract]

2023 Jan 9;164(3):bqac217. PMID: 36592127
BMC Pulm Med

Opposing responses of the rat pulmonary artery and vein to phenylephrine and other agents in vitro. [Abstract]

2021 Jun 5;21(1):189. PMID: 34090386
Continence (Amst)

Endogenous vasopressin and vasopressin receptor 2 in bladder as anti-diuretic / anti-spasmodic targets for the treatment of multifactorial nocturia. [Abstract]

2025 Dec:16:102292. PMID: 41503219
SSRN

2026 Jun 16.
Research Square Preprint

2023 Sep 11.
SSRN

2023 May 30.
Chemosphere

Prenatal exposure of female mice to perﬂuorononanoic acid delays pubertal activation of the reproductive endocrine axis through enhanced hepatic FGF21 production. [Abstract]

2021 Apr:269:128776. PMID: 33131727
The Pharma Innovation

2020; 9(7): 553-560.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shruti Mohan, et al. Vasopressin receptors in islets enhance glucose tolerance, pancreatic beta-cell secretory function, proliferation and survival. Biochimie [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Argipressin diacetate

17 Cited Publications

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Argipressin diacetate

Publications Citing Use of MedChemExpress (MCE) Argipressin diacetate

All Vasopressin Receptor Isoforms

Biological Activity

Chemical Information

Publications (17)

Purity & Documentation

References

Calculators

Help & FAQs

Argipressin diacetate Related Classifications

HY-P0049A Related Classifications