Argipressin  (Synonyms: Arg8-vasopressin; AVP)

Argipressin (Arg8-vasopressin) binds to the V1, V2, V3-vascular arginine vasopressin receptor, with a K_d value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1.

Argipressin binds to the vascular arginine vasopressin receptor, V1, with a K_d value of 1.31 nM in A7r5 rat aortic smooth muscle cells. It also stimulates the intracellular release of calcium in A7r5 cells (EC₅₀=5 nM)^[1]. AVP-induced [Ca²⁺]_i signals and immunized activity against S-100 in DRG cell culture. The minimum effective concentrations of Argipressin causing [Ca²⁺]_i responses are 100 pM in non-neuronal cells in DRG culture^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1084.23

Solid

C₄₆H₆₅N₁₅O₁₂S₂

113-79-1

Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bridge: Cys1-Cys6)

CYFQNCPRG-NH2 (Disulfide bridge: Cys1-Cys6)

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 1 years; -20°C, 6 months (sealed storage, away from moisture and light, under nitrogen)

• [1]. Thibonnier M, et al. Multiple signaling pathways of V1-vascular vasopressin receptors of A7r5 cells. Endocrinology. 1991 Dec;129(6):2845-56.  [Content Brief]

  [2]. Moriya T, et al. Vasopressin-induced intracellular Ca²⁺ concentration responses in non-neuronal cells of the rat dorsal root ganglion. Brain Res. 2012 Nov 5;1483:1-12.  [Content Brief]

  [3]. Keun Suk Park, et al. Role of vasopressin in current anesthetic practice. Korean J Anesthesiol. 2017 Jun; 70(3): 245–257.  [Content Brief]