Argipressin (Synonyms: Arg8-vasopressin; AVP)

Name: Argipressin
Brand: MedChemExpress
SKU: HY-P0049
Rating: 5.0 (10 reviews)

Cat. No.: HY-P0049 Purity: 98.71%: Data Sheet
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Argipressin (Arg8-vasopressin) binds to the V1, V2, V3-vascular arginine vasopressin receptor, with a K_d value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1.

For research use only. We do not sell to patients.

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CAS No. : 113-79-1

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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Based on 10 publication(s) in Google Scholar

Other Forms of Argipressin:

10 Publications Citing Use of MCE Argipressin

Cell Proliferation/Viability Assay

Cell Imaging/Staining

: Argipressin purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Dec:206:115265. [Abstract]; H9c2 cell viability measured 48 h after exposure to different arginine Argipressin (AVP) concentrations (0–500 µM).

: Argipressin purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Dec:206:115265. [Abstract]; Representative images of Argipressin (AVP) (300 µM) TUNEL staining.

: Argipressin purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Dec:206:115265. [Abstract]; Argipressin (AVP) (300 µM). Representative Western blot images.

: Argipressin purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Dec:206:115265. [Abstract]; Argipressin (AVP) (300 µM). Representative fluorescence images of DCFH-DA loading and quantitative analysis of reactive oxygen species (ROS) levels in H9c2 cells of the Con and AVP groups.

: Argipressin purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Dec:206:115265. [Abstract]; Argipressin (AVP) (300 µM). Representative immunofluorescence images of nuclear factor E2-associated factor 2 (Nrf2) expression in two groups of cells.

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V1a Receptor V1b Receptor V2 Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

Argipressin (Arg8-vasopressin) binds to the V1, V2, V3-vascular arginine vasopressin receptor, with a K_d value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1.

IC₅₀ & Target

V2 Receptor

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	2 nM Compound: AVP	Agonist activity at human vasopressin V1b receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assay Agonist activity at human vasopressin V1b receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assay	[PMID: 21428295]
CHO	EC₅₀	8.3 nM Compound: AVP	Agonist activity at human oxytocin receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assay Agonist activity at human oxytocin receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assay	[PMID: 21428295]
CHO-K1	EC₅₀	15 nM Compound: 1, AVP, [Arg8]vasopressin	Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay	[PMID: 21688787]
CHO-K1	EC₅₀	22 nM Compound: AVP	Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay	[PMID: 24874785]
COS-1	EC₅₀	41 nM Compound: 2, AVP	Activity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assay Activity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assay	[PMID: 21117646]
Flp-In-293	EC₅₀	4.3 nM Compound: 1, AVP, [Arg8]vasopressin	Agonist activity at recombinant human vasopressin V1b receptor expressed in Flp-In-293 cells by luciferase reporter gene assay Agonist activity at recombinant human vasopressin V1b receptor expressed in Flp-In-293 cells by luciferase reporter gene assay	[PMID: 21688787]
HEK293	EC₅₀	0.0035 nM Compound: AVP	Agonist activity at recombinant human V1b receptor expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method Agonist activity at recombinant human V1b receptor expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method	[PMID: 30896946]
HEK293	EC₅₀	0.004 nM Compound: AVP	Agonist activity at recombinant human V1a receptor expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method Agonist activity at recombinant human V1a receptor expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method	[PMID: 30896946]
HEK293	EC₅₀	0.05 nM Compound: 1, AVP, [Arg8]vasopressin	Agonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assay Agonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assay	[PMID: 21688787]
HEK293	EC₅₀	0.05 nM Compound: AVP	Agonist activity at human vasopressin V2 expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay Agonist activity at human vasopressin V2 expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay	[PMID: 24874785]
HEK293	EC₅₀	0.07 nM Compound: 1, AVP, [Arg8]vasopressin	Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay	[PMID: 21688787]
HEK293	EC₅₀	0.1 nM Compound: AVP	Agonist activity at recombinant human OTR expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method Agonist activity at recombinant human OTR expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method	[PMID: 30896946]
HEK293	EC₅₀	0.24 nM Compound: 1, AVP, [Arg8]vasopressin	Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay	[PMID: 21688787]
HEK293	EC₅₀	0.24 nM Compound: AVP	Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay	[PMID: 24874785]
HEK293	EC₅₀	4.3 nM Compound: AVP	Agonist activity at human vasopressin V1b expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay Agonist activity at human vasopressin V1b expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay	[PMID: 24874785]

In Vitro

Argipressin binds to the vascular arginine vasopressin receptor, V1, with a K_d value of 1.31 nM in A7r5 rat aortic smooth muscle cells. It also stimulates the intracellular release of calcium in A7r5 cells (EC₅₀=5 nM)^[1]. AVP-induced [Ca²⁺]_i signals and immunized activity against S-100 in DRG cell culture. The minimum effective concentrations of Argipressin causing [Ca²⁺]_i responses are 100 pM in non-neuronal cells in DRG culture^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1084.23

Formula

C₄₆H₆₅N₁₅O₁₂S₂

CAS No.

113-79-1

Appearance

Solid

Color

White to off-white

Sequence

Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bridge: Cys1-Cys6)

Sequence Shortening

CYFQNCPRG-NH2 (Disulfide bridge: Cys1-Cys6)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (92.23 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.9223 mL	4.6116 mL	9.2231 mL
5 mM	0.1845 mL	0.9223 mL	1.8446 mL
10 mM	0.0922 mL	0.4612 mL	0.9223 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.71%

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Data Sheet (282 KB) SDS (393 KB)

COA (259 KB) RP-HPLC (263 KB)

Handling Instructions (2659 KB)

References

[1]. Thibonnier M, et al. Multiple signaling pathways of V1-vascular vasopressin receptors of A7r5 cells. Endocrinology. 1991 Dec;129(6):2845-56. [Content Brief]

[2]. Moriya T, et al. Vasopressin-induced intracellular Ca2+ concentration responses in non-neuronal cells of the rat dorsal root ganglion. Brain Res. 2012 Nov 5;1483:1-12. [Content Brief]

[3]. Keun Suk Park, et al. Role of vasopressin in current anesthetic practice. Korean J Anesthesiol. 2017 Jun; 70(3): 245–257. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.9223 mL	4.6116 mL	9.2231 mL	23.0578 mL
	5 mM	0.1845 mL	0.9223 mL	1.8446 mL	4.6116 mL
	10 mM	0.0922 mL	0.4612 mL	0.9223 mL	2.3058 mL
	15 mM	0.0615 mL	0.3074 mL	0.6149 mL	1.5372 mL
	20 mM	0.0461 mL	0.2306 mL	0.4612 mL	1.1529 mL
	25 mM	0.0369 mL	0.1845 mL	0.3689 mL	0.9223 mL
	30 mM	0.0307 mL	0.1537 mL	0.3074 mL	0.7686 mL
	40 mM	0.0231 mL	0.1153 mL	0.2306 mL	0.5764 mL
	50 mM	0.0184 mL	0.0922 mL	0.1845 mL	0.4612 mL
	60 mM	0.0154 mL	0.0769 mL	0.1537 mL	0.3843 mL
	80 mM	0.0115 mL	0.0576 mL	0.1153 mL	0.2882 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Argipressin Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Argipressin113-79-1Arg8-vasopressin AVPVasopressin ReceptorInhibitorinhibitorinhibit

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Argipressin (Synonyms: Arg8-vasopressin; AVP)

Customer Review

Other Forms of Argipressin:

Argipressin Related Antibodies

10 Publications Citing Use of MCE Argipressin

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Vasopressin Receptor Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Argipressin Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Argipressin Related Classifications

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