Argipressin acetate
Based on 10 publication(s) in Google Scholar
Argipressin (Arg8-vasopressin) (acetate) binds to the V1, V2, V3-vascular arginine vasopressin receptor, with a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1.
For research use only. We do not sell to patients.
- Purity: 99.16%
- CAS No.: 129979-57-3
- Formula: C46H65N15O12S2·xC2H4O2
- Molecular Weight:1084.23 (free base)
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Argipressin acetate
More- Nat Chem Biol. 2026 Jan 6. [Abstract]
- Chemosphere. 2021 Apr;269:128776. [Abstract]
- Biochem Pharmacol. 2022 Dec:206:115265. [Abstract]
- J Ethnopharmacol. 2025 Apr 9:119679. [Abstract]
- Front Pharmacol. 2019 Nov 15;10:1380. [Abstract]
- J Cell Mol Med. 2022 Nov;26(21):5493-5505. [Abstract]
- Front Neurosci. 2022 Mar 25;16:838942. [Abstract]
- BMC Pulm Med. 2021 Jun 5;21(1):189. [Abstract]
- Research Square Preprint. 2023 Sep 11.
- The Pharma Innovation. 2020; 9(7): 553-560.
Customer Validation & Images
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Cell Proliferation/Viability Assay
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Cell Imaging/Staining
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WB
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Cell Imaging/Staining
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IF
All Vasopressin Receptor Isoforms
More
Biological Activity
Argipressin (Arg8-vasopressin) (acetate) induces proliferation and prevented cytokine-induced apoptosis in rodent and human beta-cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:clonal BRIN BD11 and 1.1B4 cells
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Concentration:10-6 M
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Incubation Time:2 h
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Result:Increased proliferation of rodent and human beta-cells.
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Cell Line:clonal BRIN BD11 and 1.1B4 cells
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Concentration:10-6 M
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Incubation Time:2 h
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Result:Protected against cytokine-induced beta-cell apoptosis.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NIH Swiss mice (adult; male; 12-14weeks)[1]
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Dosage:25 nmol/kg bw
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Administration:AVP (25 nmol/kg bw; intraperitoneal injection; once)
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Result:Reduced (P<0.001) overall AUC glucose values，but not increased insulin levels in mice.
Chemical Information
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CAS No. 129979-57-3
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Appearance Solid
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Molecular Weight 1084.23 (free base)
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Formula C46H65N15O12S2·xC2H4O2
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Color White to off-white
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Synonyms
Arg8-vasopressin acetate; AVP acetate
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Sequence
Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bridge: Cys1-Cys6)
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Sequence Shortening
CYFQNCPRG-NH2 (Disulfide bridge: Cys1-Cys6)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (10)
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Journal Impact Factor
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Most Recent
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Nat Chem Biol
Photo-cross-linking-assisted deorphanization deciphers GPR50-L-LEN pairing in metabolism. [Abstract]2026 Jan 6. PMID: 41495223 -
Chemosphere
Prenatal exposure of female mice to perfluorononanoic acid delays pubertal activation of the reproductive endocrine axis through enhanced hepatic FGF21 production. [Abstract]2021 Apr;269:128776. PMID: 33131727 -
Biochem Pharmacol
Melatonin alleviates arginine vasopressin-induced cardiomyocyte apoptosis via increasing Mst1-Nrf2 pathway activity to reduce oxidative stress. [Abstract]2022 Dec:206:115265. PMID: 36183803
Argipressin acetate purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Dec:206:115265. [Abstract]
H9c2 cell viability measured 48 h after exposure to different arginine Argipressin (AVP) concentrations (0–500 µM).
Argipressin acetate purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Dec:206:115265. [Abstract]
Representative images of Argipressin (AVP) (300 µM) TUNEL staining.
Argipressin acetate purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Dec:206:115265. [Abstract]
Argipressin (AVP) (300 µM). Representative Western blot images.
Argipressin acetate purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Dec:206:115265. [Abstract]
Argipressin (AVP) (300 µM). Representative fluorescence images of DCFH-DA loading and quantitative analysis of reactive oxygen species (ROS) levels in H9c2 cells of the Con and AVP groups.
Argipressin acetate purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Dec:206:115265. [Abstract]
Argipressin (AVP) (300 µM). Representative immunofluorescence images of nuclear factor E2-associated factor 2 (Nrf2) expression in two groups of cells.
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J Ethnopharmacol
Wuling San regulates AVPR2-cAMP-PKA-CREB pathway to delay cellular senescence and ameliorate acute kidney injury. [Abstract]2025 Apr 9:119679. PMID: 40216046 -
Front Pharmacol
Intradermal Injection of Oxytocin Aggravates Chloroquine-Induced Itch Responses via Activating the Vasopressin-1a Receptor/Nitric Oxide Pathway in Mice. [Abstract]2019 Nov 15;10:1380. PMID: 31824317 -
J Cell Mol Med
Effects of arginine vasopressin on the transcriptome of prefrontal cortex in autistic rat model. [Abstract]2022 Nov;26(21):5493-5505. PMID: 36239083 -
Front Neurosci
The Changes of Amygdala Transcriptome in Autism Rat Model After Arginine Vasopressin Treatment. [Abstract]2022 Mar 25;16:838942. PMID: 35401102 -
BMC Pulm Med
Opposing responses of the rat pulmonary artery and vein to phenylephrine and other agents in vitro. [Abstract]2021 Jun 5;21(1):189. PMID: 34090386 -
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Solvent & Solubility
H2O : ≥ 100 mg/mL
* "≥" means soluble, but saturation unknown.
Purity & Documentation
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Data Sheet (284 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Shruti Mohan, et al. Vasopressin receptors in islets enhance glucose tolerance, pancreatic beta-cell secretory function, proliferation and survival. Biochimie. [Content Brief]
[2]. Thibonnier M, et al. Multiple signaling pathways of V1-vascular vasopressin receptors of A7r5 cells. Endocrinology. 1991 Dec;129(6):2845-56. [Content Brief]
[3]. Moriya T, et al. Vasopressin-induced intracellular Ca²⁺ concentration responses in non-neuronal cells of the rat dorsal root ganglion. Brain Res. 2012 Nov 5;1483:1-12. [Content Brief]
[4]. Keun Suk Park, et al. Role of vasopressin in current anesthetic practice. Korean J Anesthesiol. 2017 Jun; 70(3): 245–257. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Argipressin acetate Related Classifications
HY-W539944 Related Classifications
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