1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Vasopressin

Vasopressin 

Cat. No.: HY-B1811 Purity: 99.68%
Handling Instructions

Vasopressin is a cyclic nonapeptide that is synthesized centrally in the hypothalamus. Vasopressin participates in the hypothalamic-pituitary-adrenal axis, and regulates pituitary corticotropin secretion by potentiating the stimulatory effects of corticotropin releasing factor. Vasopressin also can act as a neurotransmitter, exerting its action by binding to specific G protein-coupled receptors.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Vasopressin Chemical Structure

Vasopressin Chemical Structure

CAS No. : 11000-17-2

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Description

Vasopressin is a cyclic nonapeptide that is synthesized centrally in the hypothalamus. Vasopressin participates in the hypothalamic-pituitary-adrenal axis, and regulates pituitary corticotropin secretion by potentiating the stimulatory effects of corticotropin releasing factor. Vasopressin also can act as a neurotransmitter, exerting its action by binding to specific G protein-coupled receptors[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

AVP (0.01 nM-1 μM) induces Ca2+ increase in Chinese hamster ovary cells expressing rat or human V1b receptors[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Vasopressin (0.03-0.3 μg/kg; i.p.) potentiates corticotropin release provoked by exogenous corticoliberin and increases corticotropin secretion subsequent to body water loss[2].
Vasopressin (0.001-0.1 mg/kg; i.p.) potently increases adjacent lying, where rats meeting for the first time lie passively next to each other[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

1084.24

Formula

C₄₆H₆₅N₁₅O₁₂S₂

CAS No.
Sequence Shortening

CYFQNCPR-NH2 (Disulfide Bridge: Cys1-Cys6)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (92.23 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9223 mL 4.6115 mL 9.2231 mL
5 mM 0.1845 mL 0.9223 mL 1.8446 mL
10 mM 0.0922 mL 0.4612 mL 0.9223 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.31 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.31 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.31 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Vasopressin
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HY-B1811
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