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  5. GPCR RDC1/CXCR-7 Antibody (YA2957)

GPCR RDC1/CXCR-7 Antibody (YA2957)

Cat. No.: HY-P83212
User Guide for Antibodies Technical Support

GPCR RDC1/CXCR-7 Antibody (YA2957) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GPCR RDC1/CXCR-7.

For research use only. We do not sell to patients.

Size Price Stock Quantity
20 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

GPCR RDC1/CXCR-7 Antibody (YA2957) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GPCR RDC1/CXCR-7.
Host

Rabbit
Clonality

Recombinant, Monoclonal
Molecular Weight
Predicted band size: 41 kDa;
Observed band size: 41 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Gene ID
Immunogen

A synthetic peptide of human GPCR RDC1
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
Sensitivity Endogenous Purity Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1 (PubMed:16107333, PubMed:19255243, PubMed:19380869, PubMed:20161793, PubMed:22300987). Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway (PubMed:16940167, PubMed:18653785, PubMed:20018651). Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness (PubMed:16940167, PubMed:18653785). In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival (PubMed:16940167, PubMed:20388803). Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration (PubMed:17804806, PubMed:18653785, PubMed:19641136, PubMed:20887389). Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12 (PubMed:18653785). Required for heart valve development (PubMed:17804806). Regulates axon guidance in the oculomotor system through the regulation of CXCL12 levels (PubMed:31211835); (Microbial infection) Acts as a coreceptor with CXCR4 for a restricted number of HIV isolates
Subcellular Localization：Cell membrane; Multi-pass membrane protein; Early endosome; Recycling endosome
Expression：
Tissue_specificity:It is expressed in monocytes, basophils, B cells, umbilical vein endothelial cells (HUVECs) , and B lymphoblasts. It is expressed at lower levels in CD4+ T lymphocytes and natural killer cells. In brain tissue, it can be detected in endothelial cells and capillaries, as well as in mature neurons of the frontal cortex and hippocampus. It is expressed during renal tubule formation in the kidneys. It is highly expressed in astrocytoma endothelial cells, microglia, and glioma cells. It is expressed at low levels in normal CD34+ progenitor cells but at high levels in several myeloid malignant cell lines. It is expressed in breast cancer but not in normal breast tissue (protein level) .

Induction:Up-regulated during cell differentiation in glioma cells
Subunit：Homodimer. Can form heterodimers with CXCR4; heterodimerization may regulate CXCR4 signaling activity. Interacts with ARRB1 and ARRB2
Database

Entrez Gene: 57007 Human ; 12778 Mouse ; 84348 Rat

SwissProt: P25106 Human ; P56485 Mouse ; O89039 Rat

OMIM: 619215 Human

Research Field

Signal Transduction
Synonyms
RDC1; CXCR7; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159
Documentation
User Guide for Antibodies (1077 KB)

GPCR RDC1/CXCR-7 Antibody (YA2957) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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