GPCR RDC1/CXCR-7 Antibody (YA2957)
(Synonyms: RDC1; CXCR7; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159)GPCR RDC1/CXCR-7 Antibody (YA2957) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GPCR RDC1/CXCR-7.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
GPCR RDC1/CXCR-7 Antibody (YA2957) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GPCR RDC1/CXCR-7.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 41 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 41 kDa
Entrez Gene: 57007 Human ; 12778 Mouse ; 84348 Rat
SwissProt: P25106 Human ; P56485 Mouse ; O89039 Rat
OMIM: 619215 Human
A synthetic peptide of human GPCR RDC1
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
GPCR RDC1/CXCR-7 is an Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Regulates axon guidance in the oculomotor system through the regulation of CXCL12 levels; (Microbial infection) Acts as a coreceptor with CXCR4 for a restricted number of HIV isolates[1][2][3][4][5][6][7][8][9][10][11][12][13].
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Subcellular Localization
Cell membrane; Multi-pass membrane protein; Early endosome; Recycling endosome
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Expression
Tissue_specificity:It is expressed in monocytes, basophils, B cells, umbilical vein endothelial cells (HUVECs) , and B lymphoblasts. It is expressed at lower levels in CD4+ T lymphocytes and natural killer cells. In brain tissue, it can be detected in endothelial cells and capillaries, as well as in mature neurons of the frontal cortex and hippocampus. It is expressed during renal tubule formation in the kidneys. It is highly expressed in astrocytoma endothelial cells, microglia, and glioma cells. It is expressed at low levels in normal CD34+ progenitor cells but at high levels in several myeloid malignant cell lines. It is expressed in breast cancer but not in normal breast tissue (protein level) .
Induction:Up-regulated during cell differentiation in glioma cells -
Subunit
Homodimer. Can form heterodimers with CXCR4; heterodimerization may regulate CXCR4 signaling activity. Interacts with ARRB1 and ARRB2
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SwissProt ID
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Synonyms
RDC1; CXCR7; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159
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Research Field
Signal Transduction
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