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Cat. No.: HY-182533

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LN5972

LN5972 is a selective ACKR3 agonist with an EC₅₀ of 3.40 μM, showing higher selectivity for ACKR3 over CXCR4. LN5972 induces β-arrestin recruitment to ACKR3/CXCR7. LN5972 reduces the surface expression of P-selectin. LN5972 is applicable to studies related to platelet-mediated thrombosis.

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CAS No.: 3035425-93-2
화학식: C₁₉H₃₀N₆O₃S
분자량:422.54

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

LN5972 Chemical Structure

CAS No.: 3035425-93-2

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- 신청
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

ACKR3

3.40 μM (EC₅₀)

All CXCR Isoforms :

In Vitro

LN5972 (0.3 nM-100 μM) acts as a superagonist for ACKR3 in HEK293T cells, inducing β-arrestin recruitment with an EC₅₀ of 3.40 μM and a maximal efficacy 161% that of CXCL12^[1].
LN5972 (100 μM; 15 min preincubation) reduces CRP-XL-induced P-selectin expression by 76% in human platelet-rich plasma^[1].
LN5972 (0.3 nM-100 μM) is selective for ACKR3 and shows no activity at CXCR4 in HEK293T cells^[1].
LN5972 shows high metabolic stability in human liver microsomes (87% remaining at 120 min) and reduced stability in mouse liver microsomes^[1].
LN5972 (up to 100 μM; 72 h) is non-cytotoxic to THP1 and HEK293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

신청

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 3035425-93-2
분자량 422.54
화학식 C₁₉H₃₀N₆O₃S
SMILES

O=C(N1CCN(CCCNC2=NN3C(C=C(CC)N=C3S2)=O)CC1)OC(C)(C)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Bayrak A, et al. Discovery and Development of First-in-Class ACKR3/CXCR7 Superagonists for Platelet Degranulation Modulation. J Med Chem. 2022;65(19):13365-13384. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- 신청
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

LN5972

All CXCR Isoforms

Biological Activity

제품 설명

IC50 & Target

In Vitro

신청

Chemical Information

순도&문서

References

Calculators

Help & FAQs

LN5972 Related Classifications

HY-182533 Related Classifications

Bioz

Keywords

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