Inhibin alpha Antibody (YA4921)

製品番号: HY-P85229: データシート User Guide for Antibodies
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Inhibin alpha Antibody (YA4921) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to Inhibin alpha.

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容量		在庫状況
50 μL		お問い合わせ
100 μL		お問い合わせ

* アイテムを追加する前、数量をご選択ください

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
説明
参考文献

製品説明

Inhibin alpha Antibody (YA4921) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to Inhibin alpha.

Host

Rabbit

Clonality

Monoclonal,Recombinant

分子量

Predicted band size: 15 kDa;

Species Reactivity

Human

SwissProt ID

P05111

Gene ID

3623 [NCBI]

Immunogen

A synthesized peptide derived from human Inhibin alpha chain. The exact sequence is proprietary to MCE.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1000
IHC-F IHC-F: Immunohistochemistry-Frozen	1:50-100
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:50-100
IF-Tissue IF-Tissue: Immunofluorescence-Tissue	1:50-100

Sensitivity	Endogenous	純度	affinity purified by Protein A
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

輸送条件

Shipping with blue ice.

Background

Function：Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins; Inhibin A is a dimer of alpha/INHA and beta-A/INHBA that functions as a feedback regulator in the hypothalamic-pituitary-gonadal (HPG) axis. Inhibits the secretion of FSH from the anterior pituitary gland by acting on pituitary gonadotrope cells. Antagonizes activin A by binding to the proteoglycan, betaglycan, and forming a stable complex with and, thereby, sequestering type II activin receptors while excluding type I receptor; Inhibin B is a dimer of alpha and beta-B that plays a crucial role in the regulation of the reproductive system by inhibiting the secretion of follicle-stimulating hormone (FSH) from the anterior pituitary gland. Thereby, maintains reproductive homeostasis in both males and females. Acts as a more potent suppressor of FSH release than inhibin A (By similarity). Functions as competitive receptor antagonist binding activin type II receptors with high affinity in the presence of the TGF-beta type III coreceptor/TGFBR3L (PubMed:34910520)

Subcellular Localization：Secreted

Expression：
Tissue_specificity:Initially found in the ovaries (granulosa cells) and testes (Stewardess cells) , it is widely distributed in various tissues, including the brain and placenta. In normal adrenal cortex, its expression is limited to the zona reticularis and the innermost zona fasciculata; in a proliferative state, its expression extends centripetally to the zona fasciculata. It is also found in adrenal cortical tumors. It is also expressed in the prostatic epithelium of benign prostatic hyperplasia, basal cell hyperplasia areas, and non-malignant areas of high-grade prostate cancer. In men, only circulating inhibin B is detected, while in women, circulating inhibin A and B are detected.

Subunit：Dimeric, linked by one or more disulfide bonds. Activin B is a dimer of alpha and beta-B. Inhibin A is a dimer of alpha and beta-A (PubMed:11786387). Inhibin B is a dimer of alpha and beta-B (PubMed:11786387). Interacts with TGFBR3L; this interaction regulates female fertility

Synonyms

INHA; Inhibin alpha chain

ドキュメンテーション

User Guide for Antibodies (1077 KB)

参考文献

[1]. /biology-dictionary/mcf7-cell.html [Content Brief]