INHA - inhibin subunit alpha Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3623

About INHA

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:219,572,310-219,575,711 (from NCBI)

This gene has 2 transcripts (splice variants), 191 orthologues, 31 paralogues and is associated with 1 phenotype. Biased expression in testis (RPKM 55.0), adrenal (RPKM 22.2) and 2 other tissues.

Summary

This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate multiple peptide products, including the alpha subunit of the Inhibin A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, Apoptosis, immune response and hormone secretion. Mutations in this gene may be associated with male infertility and premature ovarian failure in female human patients. [provided by RefSeq, Aug 2016]

INHA Products (1)

mRNA	Protein	Name
NM_002191.4	NP_002182.1	inhibin alpha chain preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to protein binding	IPI IPI: Inferred from physical interaction	10746731	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	2575216	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	9032295	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in hemoglobin biosynthetic process	IDA IDA: Inferred from direct assay	1310063	GOA
involved in regulation of cell cycle	IDA IDA: Inferred from direct assay	9032295	GOA
involved in regulation of cell population proliferation	IDA IDA: Inferred from direct assay	9032295	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of inhibin A complex	IDA IDA: Inferred from direct assay	7890768	GOA
part of inhibin-betaglycan-ActRII complex	IDA IDA: Inferred from direct assay	10746731	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INHA Protein Structure

TGF_beta

0
100
200
300
366 a.a.

Protein Preferred Names	Protein Names
inhibin alpha chain	A-inhibin subunit

INHA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	INHA	P05111	SIAH1	Homo sapiens	Q8IUQ4-2	Validated Y2H	25910212
Intra	INHA	P05111	SIAH1	Homo sapiens	Q8IUQ4-2	Y2H Array	25910212
Intra	INHA	P05111	SIAH1	Homo sapiens	Q8IUQ4-2	Y2H Bait-Prey Pool	25910212
Intra	INHA	P05111	SIAH1	Homo sapiens	Q8IUQ4	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

INHA Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81487	Inhibin alpha Antibody (YA1232)	IHC-P	Human
HY-P81487A	Inhibin alpha Antibody (YA1232)(PBS only)	IHC-P	Human
HY-P83955	Inhibin alpha Antibody (YA3652)	WB, ICC/IF, ELISA	Human, Mouse
HY-P83955A	Inhibin alpha Antibody (YA3652)(PBS only)	WB, ICC/IF, ELISA	Human, Mouse
HY-P85229	Inhibin alpha Antibody (YA4921)	IHC-P, IHC-F, ICC/IF, IF-Tissue	Human

Related Diseases

Diseases	Alias
Multidrug-Resistant Tuberculosis	Tuberculosis, Multidrug-Resistant Tuberculosis Multidrug-Resistant
Sertoli Cell Tumor	Tubular Androblastoma
Cystadenoma	Cystoma Craniopharyngioma
Sex Cord-Gonadal Stromal Tumor	Sex Cord-Gonadal Stromal Tumour Sex Cord Stromal Tumour Sex Cord-Stromal Neoplasm Specialized Gonadal Neoplasm Specialized Gonadal Tumor Specialized Gonadal Tumour Sex Cord-Gonadal Stromal Tumors Sex Cord-Stromal Tumor Malignant Testicular Sex Cord-Stromal Tumor Sex Cord Stromal Tumor Of Testis
Infertility
Placental Site Trophoblastic Tumor	Trophoblastic Tumor Placental Site Trophoblastic Tumor, Placental Site Placental Site Trophoblastic Tumour Placental-Site Gestational Trophoblastic Neoplasm Placenta Neoplasm Psst Deciduoma Placental Cancer Primary Malignant Neoplasm Of Placenta
Trophoblastic Neoplasm	Trophoblastic Tumor Trophoblastic Neoplasms
Hemangioblastoma	Capillary Hemangioblastoma
Granular Cell Tumor	Abrikosov'S Tumor Neoplasm Of Granular Cell Abrikosoff'S Granulous Cell Tumor Abrikosoff'S Tumor Giant Granulocellular Abrikosov'S Tumor Malignant Variant Of Abrikosov'S Tumor Carcinoma, Granular Cell
Pulmonary Tuberculosis	Tuberculosis, Pulmonary PTB Tuberculosis Pulmonary
Parovarian Cyst	Cyst, Fimbrial Embryonic Fimbrial Cyst
Mycobacterium Tuberculosis 1	Tuberculosis Tuberculoma Tuberculosis, Susceptibility To Mycobacterium Tuberculosis, Susceptibility To, 1 Mtbs1 TB
Twinning, Dizygotic	Ovarian Response To Fsh Stimulation
Seminoma	Seminoma, Pure
Gynecomastia
Adrenal Cortical Adenoma	Adrenocortical Adenoma Adenoma Adrenocortical
Adrenogenital Syndrome	Adrenogenital Disease Adrenogenital Syndrome Nos
Gestational Trophoblastic Neoplasm	Hydatidiform Mole Molar Pregnancy Gestational Trophoblastic Neoplasia Gestational Trophoblastic Tumor Gtn Gestational Trophoblastic Disease Gestational Trophoblastic Neoplasms Hydatidiform Mole, Recurrent, 1 Hydatidiform Mole Benign Trophoblastic Disease Trophoblastic Disease Nos Trophoblastic Disorder Vesicular Mole Nos Vesicular Mole Hydatidiform Mole Nos
Leydig Cell Tumor	Leydig Cell Neoplasm Tumor, Leydig Cell Leydig Cell Tumor, Benign
Male Infertility	Infertility, Male Infertility Male Male Sterility Absolute Infertility
Choriocarcinoma	Chorioepithelioma
Sertoli-Leydig Cell Tumor	Sertoli-Leydig Cell Tumors Androblastoma Of Ovary Arrhenoblastoma Arrhenoblastoma Of Ovary Sertoli-Leydig Cell Tumor Of The Ovary Sertoli-Leydig Cell Tumor Of Intermediate Differentiation Sertoli-Leydig Cell Tumor Of Ovary
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Adrenal Cortical Carcinoma	Adrenocortical Carcinoma Adrenal Cortex Carcinoma Carcinoma Of The Adrenal Cortex Acc Adrenocortical Cancer Carcinoma Adrenocortical
Endodermal Sinus Tumor	Yolk Sac Tumor Endodermal Sinus Tumour Hepatoid Yolk Sac Tumour Infantile Embryonal Carcinoma Yolk Sac Neoplasm Yolk Sac Tumour
Adenofibroma
Dysgerminoma
Peutz-Jeghers Syndrome	PJS Polyposis, Hamartomatous Intestinal Polyps-And-Spots Syndrome Lentiginosis, Perioral Periorificial Lentiginosis Syndrome Hamartomatous Intestinal Polyposis Hamartomatous Polyp Colonic Hamartomatous Polyp Gastric Peutz-Jeghers Polyp Peutz Jeghers Colon Polyp Peutz Jeghers Polyp Peutz-Jeghers Polyp Of Small Intestine Peutz-Jeghers Small Bowel Hamartoma Peutz Jeghers Polyposis Intestinal Polyposis-Cutaneous Pigmentation Syndrome Peutz-Jeghers Polyposis Polyposis, Intestinal, Ii Intestinal Hamartomatous Polyposis Peutz-Jeghers Polyp Peutz-Jeghers Polyp Of The Stomach Peutz Jehgers Polyp Peutz-Jeghers Polyps Of Small Bowel
Hydatidiform Mole, Recurrent, 1	Hydatidiform Mole Gestational Trophoblastic Disease Complete Hydatidiform Mole Hydm HYDM1 Chm Molar Pregnancy Hydatidiform Mole, Complete Hydatid Mole Complete Molar Pregnancy Mole, Hydatidiform, Recurrent, Type 1 Gestational Trophoblastic Neoplasms Hydatidiform Mole, Recurrent, 2 Classical Hydatidiform Mole
Premature Ovarian Failure 1	Ovarian Failure, Premature Fmr1-Related Primary Ovarian Insufficiency Fragile X-Associated Primary Ovarian Insufficiency POF1 Pofx Hypergonadotropic Ovarian Failure, X-Linked Pof Primary Ovarian Insufficiency, Fragile X-Associated Primary Ovarian Insufficiency 1 Ovarian Failure Premature Premature Ovarian Failure, X-Linked Fragile X Premature Ovarian Failure Fmr1-Related Premature Ovarian Failure Familial Premature Ovarian Failure Idiopathic Familial Premature Ovarian Failure Fxpoi X-Linked Hypergonadotropic Ovarian Failure Hypergonadotropic Ovarian Failure X-Linked Poi Premature Ovarian Failure X-Linked Primary Ovarian Insufficiency Premature Ovarian Failure-1 Ovarian Failure, Premature, Type 1 Premature Ovarian Failure, Familial Premature Menopause Primary Hypogonadism Turner Syndrome
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Hellp Syndrome	Hemolysis, Elevated Liver Enzymes, Lowered Platelets Hemolysis, Elevated Liver Enzymes, Low Platelets In Pregnancy Hemolysis-Elevated Liver Enzymes-Low Platelets Syndrome Hellp - [Syndrome Of Haemolysis, Elevated Liver Enzymes And Low Platelet] Haemolysis-Elevated Liver Enzymes-Low Platelet Count Syndrome
Germinoma
Pre-Eclampsia	Preeclampsia Gestational Hypertension Hypertension Induced By Pregnancy Pre-Eclamptic Toxaemia Pregnancy Associated Hypertension Proteinuric Hypertension Of Pregnancy Hypertension, Pregnancy-Induced, Susceptibility To Preeclampsia/Eclampsia Pregnancy Toxemia Toxaemia Of Pregnancy Gestational Proteinuric Hypertension Pregnancy-Induced Hypertension Toxemia Of Pregnancy Preeclampsia, Susceptibility To Transient Hypertension Of Pregnancy Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria Gestational Hypertension Nos Mild Proteinuric Hypertension Of Pregnancy Pih - [Pregnancy-Induced Hypertension] Pregnancy-Induced Hypertension Nos Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria Pe - [Pre-Eclampsia] Pre-Eclampsia Nos Pre-Eclamptic Nos Pregnancy Pre-Eclampsia Puerperal Pre-Eclampsia Pre-Eclampsia Toxaemia Toxaemia In Pregnancy Pet - [Pre-Eclamptic Toxaemia] Maternal Toxaemia
Hypogonadotropic Hypogonadism	Klinefelter Syndrome Klinefelter'S Syndrome Xxy Syndrome Xxy Trisomy Hypogonadotropism 47, Xxy Congenital Idiopathic Hypogonadotropic Hypogonadism Isolated Congenital Gonadotropin Deficiency 47,Xxy Syndrome 47, Xxy Syndrome Klinefelters Syndrome Hypogonadism Klinefelter Syndrome In Males Klinefelter Syndrome, Unspecified Klinefelter Syndrome Karyotype 47, Xxy
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Down Syndrome	Trisomy 21 Complete Trisomy 21 Syndrome Down'S Syndrome Trisomy 21 Syndrome Down'S Syndrome - Trisomy 21 Downs Syndrome G Trisomy 47,Xx,+21 47,Xy,+21 Trisomy G Down Syndrome, Susceptibility To Chromosome 21 Trisomy Trisomy 21 Nos Abnormal Autosomes 21
Premature Menopause	Primary Ovarian Insufficiency Premature Ovarian Failure Hypergonadotropic Hypogonadism Premature Ovarian Insufficiency Menopause - Premature Menopause Praecox Menopause Premature Menopause, Premature Female Hypergonadotropic Hypogonadism Hypergonadotrophic Ovarian Failure Primary Female Hypogonadism Pof - [Premature Ovarian Failure] Ovarian Failure Ovarian Secretion Suppression Ovary Hyposecretion Ovary Secretion Deficiency Premature Menopause Nos
Endometrial Stromal Sarcoma	Ess Endometrial Stromal Sarcoma, High Grade Undifferentiated Endometrial Sarcoma Stromal Sarcoma Of The Corpus Uteri Sarcoma Endometrial Stromal Sarcoma, Endometrial Stromal Undifferentiated Stromal Sarcoma
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0306	Prothionamide	Inhibitor	99.87%	Unkown

Pre-clinical Phase

Bioactive Molecules (28)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122643	NITD-916	Inhibitor	99.83%	Unkown
HY-111402	Pyridomycin	Inhibitor	/	Unkown
HY-147047	InhA-IN-2	Inhibitor	/	Unkown
HY-150588	InhA-IN-3	Inhibitor	99.66%	Unkown
HY-150589	InhA-IN-4	Inhibitor	/	Unkown
HY-159565	VEGFR-2/InhA-IN-1	Inhibitor	/	Unkown
HY-160644	8PC		/	Unkown
HY-160648	InhA-IN-6	Inhibitor	/	Unkown
HY-160653	JPL	Inhibitor	/	Unkown
HY-160678	InhA-IN-7	Inhibitor	/	Unkown
HY-162033	PAT1inh-A0030	Inhibitor	/	Unkown
HY-169104	InhA-IN-8	Inhibitor	/	Unkown
HY-179529	EGFR/InhA-IN-1	Inhibitor	/	Unkown
HY-183998	Antitubercular agent-60	Inhibitor	/	Unkown
HY-B0306S	Prothionamide-d5	Inhibitor	/	Unkown
HY-N19293	Aquastatin C	Control	/	Unkown
HY-RS06812	INHA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-120884	InhA-IN-5	Inhibitor	/	Unkown
HY-124107	UTA1inh-A1	Inhibitor	/	Unkown
HY-168946	InhA-IN-9	Inhibitor	/	Unkown
HY-169635	Mycobacterium Tuberculosis-IN-6	Inhibitor	/	Unkown
HY-180854	Antitubercular agent-55	Inhibitor	/	Unkown
HY-181269	InhA-IN-11	Inhibitor	/	Unkown
HY-181419	Antimycobacterial agent-16	Inhibitor	/	Unkown
HY-181779	Pyridomycin-4-F	Inhibitor	/	Unkown
HY-181866	Antibacterial agent 328	Inhibitor	/	Unkown
HY-RS19905	Inha Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26406	Inha Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	INHA	VGNC	VGNC:73744
Rattus norvegicus	INHA	RGD	RGD:2912
Bos taurus	INHA	VGNC	VGNC:30199
Felis catus	INHA	VGNC	VGNC:67804
Canis familiaris	INHA	VGNC	VGNC:42020
Mus musculus	INHA	MGD	MGI:96569
Others	INHA	NCBI